Recombinant amyloid beta-peptide production by coexpression with an affibody ligand.

• Published in: BMC Biotechnology
• Main Authors: Macao, Bertil, Hoyer, Wolfgang, Sandberg, Anders, Brorsson, Ann-Christin, Dobson, Christopher M, Härd, Torleif
• Format: Article in Journal/Newspaper
• Language: English
• Published: Department of Medical Biochemistry, University of Gothenburg 2008
• Subjects: Natural Sciences; Naturvetenskap; Arctic; Bertil; Sandberg
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45430; https://doi.org/10.1186/1472-6750-8-82

BACKGROUND: Oligomeric and fibrillar aggregates of the amyloid beta-peptide (Abeta) have been implicated in the pathogenesis of Alzheimer's disease (AD). The characterization of Abeta assemblies is essential for the elucidation of the mechanisms of Abeta neurotoxicity, but requires large quanti...