Platelet function testing : Current practice among clinical centres in Northern Europe
Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice amon...
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Linköpings universitet, Avdelningen för klinisk kemi och farmakologi
2022
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185275 https://doi.org/10.1111/hae.14578 |
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ftlinkoepinguniv:oai:DiVA.org:liu-185275 2023-05-15T16:51:38+02:00 Platelet function testing : Current practice among clinical centres in Northern Europe Szanto, Timea Zetterberg, Eva Ramström, Sofia Leinoe, Eva B. Holme, Pal A. Antovic, Jovan P. Holmström, Margareta Onundarson, Pall T. Pikta, Marika Vaide, Ines Olsson, Anna Magnusson, Maria Kärkkäinen, Satu Bitar, Manar Poulsen, Lone Hvitfeldt Lassila, Riitta 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185275 https://doi.org/10.1111/hae.14578 eng eng Linköpings universitet, Avdelningen för klinisk kemi och farmakologi Linköpings universitet, Medicinska fakulteten Region Östergötland, Klinisk kemi Linköpings universitet, Avdelningen för diagnostik och specialistmedicin Region Östergötland, Medicinska och geriatriska akutkliniken Helsinki Univ Hosp, Finland; Univ Helsinki, Finland Lund Univ, Sweden; Lund Univ, Sweden Orebro Univ, Sweden Copenhagen Univ Hosp, Denmark Univ Oslo, Norway; Univ Oslo, Norway Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden Univ Iceland, Iceland North Estonia Med Ctr, Estonia Univ Tartu, Estonia Sahlgrens Univ Hosp, Sweden Fimlab Lab, Finland Orebro Univ Hosp, Sweden Aarhus Univ Hosp, Denmark Wiley Haemophilia, 1351-8216, 2022 orcid:0000-0002-1920-3962 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185275 doi:10.1111/hae.14578 PMID 35510959 ISI:000790857600001 info:eu-repo/semantics/openAccess blood platelet disorders data collection platelet function testing platelets survey Cardiac and Cardiovascular Systems Kardiologi Article in journal info:eu-repo/semantics/article text 2022 ftlinkoepinguniv https://doi.org/10.1111/hae.14578 2022-06-22T22:27:31Z Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice among centres performing platelet function tests in Northern Europe. Methods A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million. Results Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11/14 (78.6%) centres and family history in all. Five/14 centres (35.7%) use structured preanalytical patient instructions, and 10/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10/14 (71.4%), while in 4/14 (28.6%), the diagnostic work-up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work-up of IPFD includes peripheral blood smear in 10/14 (71.4%), platelet aggregometry in all, flow cytometry in 10/14 (71.4%) and Platelet Function Analysis (PFA) in 3/11 (28.6%). Molecular genetic diagnosis is available in 7/14 (50%) centres. Conclusions The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA). Funding Agencies|Helsinki University Hospital [TYH2020318] Article in Journal/Newspaper Iceland LIU - Linköping University: Publications (DiVA) Norway Haemophilia |
institution |
Open Polar |
collection |
LIU - Linköping University: Publications (DiVA) |
op_collection_id |
ftlinkoepinguniv |
language |
English |
topic |
blood platelet disorders data collection platelet function testing platelets survey Cardiac and Cardiovascular Systems Kardiologi |
spellingShingle |
blood platelet disorders data collection platelet function testing platelets survey Cardiac and Cardiovascular Systems Kardiologi Szanto, Timea Zetterberg, Eva Ramström, Sofia Leinoe, Eva B. Holme, Pal A. Antovic, Jovan P. Holmström, Margareta Onundarson, Pall T. Pikta, Marika Vaide, Ines Olsson, Anna Magnusson, Maria Kärkkäinen, Satu Bitar, Manar Poulsen, Lone Hvitfeldt Lassila, Riitta Platelet function testing : Current practice among clinical centres in Northern Europe |
topic_facet |
blood platelet disorders data collection platelet function testing platelets survey Cardiac and Cardiovascular Systems Kardiologi |
description |
Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice among centres performing platelet function tests in Northern Europe. Methods A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million. Results Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11/14 (78.6%) centres and family history in all. Five/14 centres (35.7%) use structured preanalytical patient instructions, and 10/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10/14 (71.4%), while in 4/14 (28.6%), the diagnostic work-up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work-up of IPFD includes peripheral blood smear in 10/14 (71.4%), platelet aggregometry in all, flow cytometry in 10/14 (71.4%) and Platelet Function Analysis (PFA) in 3/11 (28.6%). Molecular genetic diagnosis is available in 7/14 (50%) centres. Conclusions The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA). Funding Agencies|Helsinki University Hospital [TYH2020318] |
format |
Article in Journal/Newspaper |
author |
Szanto, Timea Zetterberg, Eva Ramström, Sofia Leinoe, Eva B. Holme, Pal A. Antovic, Jovan P. Holmström, Margareta Onundarson, Pall T. Pikta, Marika Vaide, Ines Olsson, Anna Magnusson, Maria Kärkkäinen, Satu Bitar, Manar Poulsen, Lone Hvitfeldt Lassila, Riitta |
author_facet |
Szanto, Timea Zetterberg, Eva Ramström, Sofia Leinoe, Eva B. Holme, Pal A. Antovic, Jovan P. Holmström, Margareta Onundarson, Pall T. Pikta, Marika Vaide, Ines Olsson, Anna Magnusson, Maria Kärkkäinen, Satu Bitar, Manar Poulsen, Lone Hvitfeldt Lassila, Riitta |
author_sort |
Szanto, Timea |
title |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_short |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_full |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_fullStr |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_full_unstemmed |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_sort |
platelet function testing : current practice among clinical centres in northern europe |
publisher |
Linköpings universitet, Avdelningen för klinisk kemi och farmakologi |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185275 https://doi.org/10.1111/hae.14578 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Haemophilia, 1351-8216, 2022 orcid:0000-0002-1920-3962 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185275 doi:10.1111/hae.14578 PMID 35510959 ISI:000790857600001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/hae.14578 |
container_title |
Haemophilia |
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1766041739371479040 |