Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018
Background The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment...
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Linköpings universitet, Avdelningen för inflammation och infektion
2021
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175846 https://doi.org/10.1080/23744235.2021.1910338 |
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ftlinkoepinguniv:oai:DiVA.org:liu-175846 2024-02-04T10:01:26+01:00 Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 Möller, Vidar Östholm Balkhed, Åse Berild, Dag Fredrikson, Mats Gottfredsson, Magnus Holmbom, Martin Järvinen, Asko Kristjansson, Mar Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan 2021 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175846 https://doi.org/10.1080/23744235.2021.1910338 eng eng Linköpings universitet, Avdelningen för inflammation och infektion Linköpings universitet, Medicinska fakulteten Region Östergötland, Infektionskliniken i Östergötland Linköpings universitet, Avdelningen för kirurgi, ortopedi och onkologi Region Östergötland, Urologiska kliniken i Östergötland Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin Linköpings universitet, Hälsouniversitetet Oslo Univ Hosp, Norway; Univ Oslo, Norway Landspitali Univ Hosp, Iceland; Univ Iceland, Iceland Helsinki Univ Hosp, Finland; Univ Helsinki, Finland Statens Serum Inst, Denmark Odense Univ Hosp, Denmark Infectious Diseases, 2374-4235, 2021, 53:8, s. 607-618 orcid:0000-0002-8250-8785 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175846 doi:10.1080/23744235.2021.1910338 PMID 33970737 ISI:000648771100001 info:eu-repo/semantics/openAccess Antibiotic resistance practice guidelines as topic antibiotic stewardship Nordic countries Infectious Medicine Infektionsmedicin Article in journal info:eu-repo/semantics/article text 2021 ftlinkoepinguniv https://doi.org/10.1080/23744235.2021.1910338 2024-01-10T23:32:56Z Background The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. Methods Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. Results Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (<10%) except in Finland and Iceland (<15%), but benzylpenicillin was recommended for community-acquired pneumonia in all countries. Conclusion Despite similar resistance rates among Enterobacteriaceae there were differences in practice guidelines for pyelonephritis and sepsis. National surveillance of antibiotic resistance can be used for comparison and optimization of guidelines and stewardship interventions to preserve the low levels of antibiotic resistance in Nordic countries. Funding Agencies|Region Ostergotland; VINNOVA ... Article in Journal/Newspaper Iceland LIU - Linköping University: Publications (DiVA) Norway Infectious Diseases 53 8 607 618 |
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Open Polar |
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LIU - Linköping University: Publications (DiVA) |
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ftlinkoepinguniv |
language |
English |
topic |
Antibiotic resistance practice guidelines as topic antibiotic stewardship Nordic countries Infectious Medicine Infektionsmedicin |
spellingShingle |
Antibiotic resistance practice guidelines as topic antibiotic stewardship Nordic countries Infectious Medicine Infektionsmedicin Möller, Vidar Östholm Balkhed, Åse Berild, Dag Fredrikson, Mats Gottfredsson, Magnus Holmbom, Martin Järvinen, Asko Kristjansson, Mar Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
topic_facet |
Antibiotic resistance practice guidelines as topic antibiotic stewardship Nordic countries Infectious Medicine Infektionsmedicin |
description |
Background The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. Methods Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. Results Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (<10%) except in Finland and Iceland (<15%), but benzylpenicillin was recommended for community-acquired pneumonia in all countries. Conclusion Despite similar resistance rates among Enterobacteriaceae there were differences in practice guidelines for pyelonephritis and sepsis. National surveillance of antibiotic resistance can be used for comparison and optimization of guidelines and stewardship interventions to preserve the low levels of antibiotic resistance in Nordic countries. Funding Agencies|Region Ostergotland; VINNOVA ... |
format |
Article in Journal/Newspaper |
author |
Möller, Vidar Östholm Balkhed, Åse Berild, Dag Fredrikson, Mats Gottfredsson, Magnus Holmbom, Martin Järvinen, Asko Kristjansson, Mar Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan |
author_facet |
Möller, Vidar Östholm Balkhed, Åse Berild, Dag Fredrikson, Mats Gottfredsson, Magnus Holmbom, Martin Järvinen, Asko Kristjansson, Mar Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan |
author_sort |
Möller, Vidar |
title |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
title_short |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
title_full |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
title_fullStr |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
title_full_unstemmed |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018 |
title_sort |
antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in nordic hospitals 2010-2018 |
publisher |
Linköpings universitet, Avdelningen för inflammation och infektion |
publishDate |
2021 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175846 https://doi.org/10.1080/23744235.2021.1910338 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Infectious Diseases, 2374-4235, 2021, 53:8, s. 607-618 orcid:0000-0002-8250-8785 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175846 doi:10.1080/23744235.2021.1910338 PMID 33970737 ISI:000648771100001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/23744235.2021.1910338 |
container_title |
Infectious Diseases |
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53 |
container_issue |
8 |
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607 |
op_container_end_page |
618 |
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1789967309179191296 |