Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy

• Published in: Human Reproduction
• Main Authors: Stukenborg, J. -B., Alves-Lopes, J. P., Kurek, M., Albalushi, H., Reda, A., Keros, V., Tohonen, V., Bjarnason, R., Romerius, P., Sundin, M., Nystrom, U. Noren, Langenskiold, C., Vogt, Hartmut, Henningsohn, L., Mitchell, R. T., Soder, O., Petersen, C., Jahnukainen, K.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Linköpings universitet, Avdelningen för barns och kvinnors hälsa 2018
• Subjects: fertility preservation; childhood cancer; sickle cell disease; alkylating agents; spermatogonial quantity; Cancer and Oncology; Cancer och onkologi; Sickle; Iceland
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153711; https://doi.org/10.1093/humrep/dey240

STUDY QUESTION Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER Spermatogonial quantity is significantly reduced in testes of prepubertal boys treated with alkylating agent therap...