Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously...
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Linköpings universitet, Biologi
2017
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ftlinkoepinguniv:oai:DiVA.org:liu-142438 2024-01-28T10:05:06+01:00 Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs Persson, Mia Trottier, Agaia J. Bélteky, Johan Roth, Lina Jensen, Per 2017 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142438 https://doi.org/10.1016/j.yhbeh.2017.07.016 eng eng Linköpings universitet, Biologi Linköpings universitet, Tekniska fakulteten ACADEMIC PRESS INC ELSEVIER SCIENCE Hormones and Behavior, 0018-506X, 2017, 95, s. 85-93 orcid:0000-0002-6115-7517 orcid:0000-0001-5508-4465 orcid:0000-0002-3297-1130 orcid:0000-0001-5491-0649 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142438 doi:10.1016/j.yhbeh.2017.07.016 PMID 28765081 ISI:000412863500010 info:eu-repo/semantics/openAccess Oxytocin Oxytocin receptor gene OXTR Domestic dog Canine Wolf Canis lupus Behavior genetics Canine behavior Social behavior Other Biological Topics Annan biologi Article in journal info:eu-repo/semantics/article text 2017 ftlinkoepinguniv https://doi.org/10.1016/j.yhbeh.2017.07.016 2024-01-03T23:32:46Z The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in doge communicative skills. Here we have utilized the unsolvable problem paradigm to investigate the effects of oxytocin and OXTR polymorphisms on human-directed contact seeking behavior in 60 golden retriever dogs. Human-oriented behavior was quantified employing a previously defined unsolvable problem paradigm. Behaviors were tested twice in a repeated, counterbalanced design, where dogs received a nasal dose of either oxytocin or saline 45 min before each test occasion. Buccal DNA was analysed for genotype on three previously identified SNP-markers associated with OXTR. The same polymorphisms were also geno-typed in 21 wolf blood samples to explore potential genomic differences between the species. Results showed that oxytocin treatment decreased physical contact seeking with the experimenter and one of the three polymorphisms was associated with degree of physical contact seeking with the owner. Dogs with the AA-genotype at this locus increased owner physical contact seeking in response to oxytocin while the opposite effect was found in GG-genotype individuals. Hence, intranasal oxytocin treatment, an OXTR polymorphism and their interaction are associated with doge human-directed social skills, which can explain previously described breed differences in oxytocin response. Genotypic variation at the studied locus was also found in wolves indicating that it was present even at the start of dog domestication. Funding Agencies|European Research Council (ERC) [322206] Article in Journal/Newspaper Canis lupus LIU - Linköping University: Publications (DiVA) Hormones and Behavior 95 85 93 |
institution |
Open Polar |
collection |
LIU - Linköping University: Publications (DiVA) |
op_collection_id |
ftlinkoepinguniv |
language |
English |
topic |
Oxytocin Oxytocin receptor gene OXTR Domestic dog Canine Wolf Canis lupus Behavior genetics Canine behavior Social behavior Other Biological Topics Annan biologi |
spellingShingle |
Oxytocin Oxytocin receptor gene OXTR Domestic dog Canine Wolf Canis lupus Behavior genetics Canine behavior Social behavior Other Biological Topics Annan biologi Persson, Mia Trottier, Agaia J. Bélteky, Johan Roth, Lina Jensen, Per Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
topic_facet |
Oxytocin Oxytocin receptor gene OXTR Domestic dog Canine Wolf Canis lupus Behavior genetics Canine behavior Social behavior Other Biological Topics Annan biologi |
description |
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in doge communicative skills. Here we have utilized the unsolvable problem paradigm to investigate the effects of oxytocin and OXTR polymorphisms on human-directed contact seeking behavior in 60 golden retriever dogs. Human-oriented behavior was quantified employing a previously defined unsolvable problem paradigm. Behaviors were tested twice in a repeated, counterbalanced design, where dogs received a nasal dose of either oxytocin or saline 45 min before each test occasion. Buccal DNA was analysed for genotype on three previously identified SNP-markers associated with OXTR. The same polymorphisms were also geno-typed in 21 wolf blood samples to explore potential genomic differences between the species. Results showed that oxytocin treatment decreased physical contact seeking with the experimenter and one of the three polymorphisms was associated with degree of physical contact seeking with the owner. Dogs with the AA-genotype at this locus increased owner physical contact seeking in response to oxytocin while the opposite effect was found in GG-genotype individuals. Hence, intranasal oxytocin treatment, an OXTR polymorphism and their interaction are associated with doge human-directed social skills, which can explain previously described breed differences in oxytocin response. Genotypic variation at the studied locus was also found in wolves indicating that it was present even at the start of dog domestication. Funding Agencies|European Research Council (ERC) [322206] |
format |
Article in Journal/Newspaper |
author |
Persson, Mia Trottier, Agaia J. Bélteky, Johan Roth, Lina Jensen, Per |
author_facet |
Persson, Mia Trottier, Agaia J. Bélteky, Johan Roth, Lina Jensen, Per |
author_sort |
Persson, Mia |
title |
Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
title_short |
Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
title_full |
Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
title_fullStr |
Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
title_full_unstemmed |
Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
title_sort |
intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs |
publisher |
Linköpings universitet, Biologi |
publishDate |
2017 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142438 https://doi.org/10.1016/j.yhbeh.2017.07.016 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
Hormones and Behavior, 0018-506X, 2017, 95, s. 85-93 orcid:0000-0002-6115-7517 orcid:0000-0001-5508-4465 orcid:0000-0002-3297-1130 orcid:0000-0001-5491-0649 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142438 doi:10.1016/j.yhbeh.2017.07.016 PMID 28765081 ISI:000412863500010 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.yhbeh.2017.07.016 |
container_title |
Hormones and Behavior |
container_volume |
95 |
container_start_page |
85 |
op_container_end_page |
93 |
_version_ |
1789331211912478720 |