Subgenotype reclassification of genotype B hepatitis B virus
Abstract Background Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addition, subgenotype B6 was designated twice for viruses of different orig...
Published in: | BMC Gastroenterology |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2012
|
Subjects: | |
Online Access: | http://hdl.handle.net/10147/263235 https://doi.org/10.1186/1471-230X-12-116 |
id |
ftlenus:oai:www.lenus.ie:10147/263235 |
---|---|
record_format |
openpolar |
spelling |
ftlenus:oai:www.lenus.ie:10147/263235 2024-06-09T07:43:45+00:00 Subgenotype reclassification of genotype B hepatitis B virus Shi, Weifeng Zhu, Chaodong Zheng, Wei Carr, Michael J Higgins, Desmond G Zhang, Zhong 2012-12-15T12:05:42Z http://hdl.handle.net/10147/263235 https://doi.org/10.1186/1471-230X-12-116 en eng BMC Gastroenterology. 2012 Aug 27;12(1):116 http://dx.doi.org/10.1186/1471-230X-12-116 http://hdl.handle.net/10147/263235 Weifeng Shi et al.; licensee BioMed Central Ltd. Journal Article 2012 ftlenus https://doi.org/10.1186/1471-230X-12-116 2024-05-16T07:17:22Z Abstract Background Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addition, subgenotype B6 was designated twice for viruses of different origin. Methods All complete genome sequences of genotype B HBV were phylogenetically analyzed. Sequence divergences between different potential subgenotypes were also assessed. Results Both phylogenetic and sequence divergence analyses supported the designation of subgenotypes B1, B2, B4, and B6 (from Arctic). However, sequence divergences between previously designated B3, B5, B7, B8, B9 and another B6 (from China) were mostly less than 4%. In addition, subgenotype B3 did not form a monophyly. Conclusion Current evidence failed to classify original B5, B7, B8, B9, and B6 (from China) as subgenotypes. Instead, they could be considered as a quasi-subgenotype B3 of Southeast Asian and Chinese origin. In addition, previously designated B6 (from Arctic) should be renamed as B5 for continuous numbering. This novel classification is well supported by both the phylogeny and sequence divergence of > 4%. Peer Reviewed Article in Journal/Newspaper Arctic Lenus - Irish Health Publications Archive (HSE - Health Service Executive) Arctic BMC Gastroenterology 12 1 |
institution |
Open Polar |
collection |
Lenus - Irish Health Publications Archive (HSE - Health Service Executive) |
op_collection_id |
ftlenus |
language |
English |
description |
Abstract Background Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addition, subgenotype B6 was designated twice for viruses of different origin. Methods All complete genome sequences of genotype B HBV were phylogenetically analyzed. Sequence divergences between different potential subgenotypes were also assessed. Results Both phylogenetic and sequence divergence analyses supported the designation of subgenotypes B1, B2, B4, and B6 (from Arctic). However, sequence divergences between previously designated B3, B5, B7, B8, B9 and another B6 (from China) were mostly less than 4%. In addition, subgenotype B3 did not form a monophyly. Conclusion Current evidence failed to classify original B5, B7, B8, B9, and B6 (from China) as subgenotypes. Instead, they could be considered as a quasi-subgenotype B3 of Southeast Asian and Chinese origin. In addition, previously designated B6 (from Arctic) should be renamed as B5 for continuous numbering. This novel classification is well supported by both the phylogeny and sequence divergence of > 4%. Peer Reviewed |
format |
Article in Journal/Newspaper |
author |
Shi, Weifeng Zhu, Chaodong Zheng, Wei Carr, Michael J Higgins, Desmond G Zhang, Zhong |
spellingShingle |
Shi, Weifeng Zhu, Chaodong Zheng, Wei Carr, Michael J Higgins, Desmond G Zhang, Zhong Subgenotype reclassification of genotype B hepatitis B virus |
author_facet |
Shi, Weifeng Zhu, Chaodong Zheng, Wei Carr, Michael J Higgins, Desmond G Zhang, Zhong |
author_sort |
Shi, Weifeng |
title |
Subgenotype reclassification of genotype B hepatitis B virus |
title_short |
Subgenotype reclassification of genotype B hepatitis B virus |
title_full |
Subgenotype reclassification of genotype B hepatitis B virus |
title_fullStr |
Subgenotype reclassification of genotype B hepatitis B virus |
title_full_unstemmed |
Subgenotype reclassification of genotype B hepatitis B virus |
title_sort |
subgenotype reclassification of genotype b hepatitis b virus |
publishDate |
2012 |
url |
http://hdl.handle.net/10147/263235 https://doi.org/10.1186/1471-230X-12-116 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
BMC Gastroenterology. 2012 Aug 27;12(1):116 http://dx.doi.org/10.1186/1471-230X-12-116 http://hdl.handle.net/10147/263235 |
op_rights |
Weifeng Shi et al.; licensee BioMed Central Ltd. |
op_doi |
https://doi.org/10.1186/1471-230X-12-116 |
container_title |
BMC Gastroenterology |
container_volume |
12 |
container_issue |
1 |
_version_ |
1801372612878663680 |