Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data.

• Published in: Circulation: Genomic and Precision Medicine
• Main Authors: Patel, RS, Schmidt, AF, Tragante, V, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Drexel, H, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, van der Laan, SW, Van Setten, J, Vilmundarson, RO, Viviani Anselmi, C, Engert, JC, Vlachopoulou, E, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Fitzpatrick, N, Fox, KAA, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Girelli, D, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Hagström, E, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Bogaty, P, de Borst, GJ, Brenner, H, Hazen, SL, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, RM, Cresci, S, de Faire, U, Doughty, RN, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Muehlschlegel, JD, Johnson, JA, de Jong, PA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Dubé, M-P, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Maitland-van der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Pepinski, W, Olivieri, O, Allayee, H, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Scholz, M, Almgren, P, Siegbahn, A, Sinisalo, J, Smith, JG, Spertus, JA, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Ten Berg, JM, Thanassoulis, G, Thiery, J, Alver, M, van der Graaf, Y, Visseren, FLJ, Waltenberger, J, Van der Harst, P, Tardif, J-C, Sattar, N, Lang, CC, Paré, G, Brophy, JM, Anderson, JL, Baranova, EV, März, W, Wallentin, L, Cameron, VA, Horne, BD, Samani, NJ, Hingorani, AD, Asselbergs, FW, Behlouli, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dufresne, L, Eriksson, N, Foco, L, Gijsberts, CM, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D
• Format: Article in Journal/Newspaper
• Language: English
• Published: American Heart Association, Lippincott, Williams & Wilkins 2019
• Subjects: chromosome; genetic variation; myocardial infarction; risk factor; secondary prevention; Nunavut; Yukon; Canada; New Zealand; British Columbia; Myers; Charity; Abbott; Stanton; Collard
• Online Access: https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002471; http://hdl.handle.net/2381/44554; https://doi.org/10.1161/CIRCGEN.119.002471

The Data Supplement is available at https://www.ahajournals.org/doi/suppl/10.1161/CIRCGEN.119.002471. BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising qu...