Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions.
Supplementary information accompanies this paper at doi:10.1038/s41598-017-11307-9 Interpretations of genetic data concerning the prehistory of Europe have long been a subject of great debate, but increasing amounts of ancient and modern DNA data are now providing new and more informative evidence....
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ftleicester:oai:lra.le.ac.uk:2381/40469 2023-05-15T18:08:18+02:00 Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. Batini, Chiara Hallast, Pille Vågene, Åshild J. Zadik, Daniel Eriksen, Heidi A. Pamjav, Horolma Sajantila, Antti Wetton, Jon H. Jobling, Mark A. 2017-11-01T14:22:34Z https://www.nature.com/articles/s41598-017-11307-9 http://hdl.handle.net/2381/40469 https://doi.org/10.1038/s41598-017-11307-9 en eng Nature Publishing Group https://www.ncbi.nlm.nih.gov/pubmed/28935946 Scientific Reports, 2017, 7 (1), 12086 2045-2322 https://www.nature.com/articles/s41598-017-11307-9 http://hdl.handle.net/2381/40469 doi:10.1038/s41598-017-11307-9 Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Biological anthropology Genetic variation Haplotypes Journal Article 2017 ftleicester https://doi.org/10.1038/s41598-017-11307-9 2019-03-22T20:23:53Z Supplementary information accompanies this paper at doi:10.1038/s41598-017-11307-9 Interpretations of genetic data concerning the prehistory of Europe have long been a subject of great debate, but increasing amounts of ancient and modern DNA data are now providing new and more informative evidence. Y-chromosome resequencing studies in Europe have highlighted the prevalence of recent expansions of male lineages, and focused interest on the Bronze Age as a period of cultural and demographic change. These findings contrast with phylogeographic studies based on mitochondrial DNA (mtDNA), which have been interpreted as supporting expansions from glacial refugia. Here we have undertaken a population-based resequencing of complete mitochondrial genomes in Europe and the Middle East, in 340 samples from 17 populations for which Y-chromosome sequence data are also available. Demographic reconstructions show no signal of Bronze Age expansion, but evidence of Paleolithic expansions in all populations except the Saami, and with an absence of detectable geographical pattern. In agreement with previous inference from modern and ancient DNA data, the unbiased comparison between the mtDNA and Y-chromosome population datasets emphasizes the sex-biased nature of recent demographic transitions in Europe. We thank Eduardo Arroyo-Pardo, Walter Bodmer, Gianpiero Cavalleri, Peter de Knijff, Berit Myhre Dupuy, Turi King, Adolfo López de Munain, Ana López-Parra, Aphrodite Loutradis, Jelena Milasin, Andrea Novelletto, Aslıhan Tolun, and Bruce Winney for assistance with DNA samples, and helpful comments; Lorna Gregory and the Oxford Genomics Centre for library preparation, target enrichment and sequencing; Rita Neumann and Pierpaolo Maisano Delser for help with IonTorrent sequencing; NUCLEUS Genomic Services at the University of Leicester for access to Illumina MiSeq sequencing; and two anonymous reviewers for helpful comments on the manuscript. CB, PH, DZ and MAJ were supported by a Wellcome Trust Senior Fellowship, grant number 087576. AS was supported by the Finnish Foundations’ Professor Pool (Paulo Foundation). This research used the ALICE High Performance Computing Facility at the University of Leicester. Peer-reviewed Publisher Version Article in Journal/Newspaper saami University of Leicester: Leicester Research Archive (LRA) Lorna ENVELOPE(62.789,62.789,-67.787,-67.787) Leicester ENVELOPE(-116.403,-116.403,55.717,55.717) Aphrodite ENVELOPE(-64.533,-64.533,-68.900,-68.900) Scientific Reports 7 1 |
institution |
Open Polar |
collection |
University of Leicester: Leicester Research Archive (LRA) |
op_collection_id |
ftleicester |
language |
English |
topic |
Biological anthropology Genetic variation Haplotypes |
spellingShingle |
Biological anthropology Genetic variation Haplotypes Batini, Chiara Hallast, Pille Vågene, Åshild J. Zadik, Daniel Eriksen, Heidi A. Pamjav, Horolma Sajantila, Antti Wetton, Jon H. Jobling, Mark A. Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
topic_facet |
Biological anthropology Genetic variation Haplotypes |
description |
Supplementary information accompanies this paper at doi:10.1038/s41598-017-11307-9 Interpretations of genetic data concerning the prehistory of Europe have long been a subject of great debate, but increasing amounts of ancient and modern DNA data are now providing new and more informative evidence. Y-chromosome resequencing studies in Europe have highlighted the prevalence of recent expansions of male lineages, and focused interest on the Bronze Age as a period of cultural and demographic change. These findings contrast with phylogeographic studies based on mitochondrial DNA (mtDNA), which have been interpreted as supporting expansions from glacial refugia. Here we have undertaken a population-based resequencing of complete mitochondrial genomes in Europe and the Middle East, in 340 samples from 17 populations for which Y-chromosome sequence data are also available. Demographic reconstructions show no signal of Bronze Age expansion, but evidence of Paleolithic expansions in all populations except the Saami, and with an absence of detectable geographical pattern. In agreement with previous inference from modern and ancient DNA data, the unbiased comparison between the mtDNA and Y-chromosome population datasets emphasizes the sex-biased nature of recent demographic transitions in Europe. We thank Eduardo Arroyo-Pardo, Walter Bodmer, Gianpiero Cavalleri, Peter de Knijff, Berit Myhre Dupuy, Turi King, Adolfo López de Munain, Ana López-Parra, Aphrodite Loutradis, Jelena Milasin, Andrea Novelletto, Aslıhan Tolun, and Bruce Winney for assistance with DNA samples, and helpful comments; Lorna Gregory and the Oxford Genomics Centre for library preparation, target enrichment and sequencing; Rita Neumann and Pierpaolo Maisano Delser for help with IonTorrent sequencing; NUCLEUS Genomic Services at the University of Leicester for access to Illumina MiSeq sequencing; and two anonymous reviewers for helpful comments on the manuscript. CB, PH, DZ and MAJ were supported by a Wellcome Trust Senior Fellowship, grant number 087576. AS was supported by the Finnish Foundations’ Professor Pool (Paulo Foundation). This research used the ALICE High Performance Computing Facility at the University of Leicester. Peer-reviewed Publisher Version |
format |
Article in Journal/Newspaper |
author |
Batini, Chiara Hallast, Pille Vågene, Åshild J. Zadik, Daniel Eriksen, Heidi A. Pamjav, Horolma Sajantila, Antti Wetton, Jon H. Jobling, Mark A. |
author_facet |
Batini, Chiara Hallast, Pille Vågene, Åshild J. Zadik, Daniel Eriksen, Heidi A. Pamjav, Horolma Sajantila, Antti Wetton, Jon H. Jobling, Mark A. |
author_sort |
Batini, Chiara |
title |
Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
title_short |
Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
title_full |
Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
title_fullStr |
Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
title_full_unstemmed |
Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. |
title_sort |
population resequencing of european mitochondrial genomes highlights sex-bias in bronze age demographic expansions. |
publisher |
Nature Publishing Group |
publishDate |
2017 |
url |
https://www.nature.com/articles/s41598-017-11307-9 http://hdl.handle.net/2381/40469 https://doi.org/10.1038/s41598-017-11307-9 |
long_lat |
ENVELOPE(62.789,62.789,-67.787,-67.787) ENVELOPE(-116.403,-116.403,55.717,55.717) ENVELOPE(-64.533,-64.533,-68.900,-68.900) |
geographic |
Lorna Leicester Aphrodite |
geographic_facet |
Lorna Leicester Aphrodite |
genre |
saami |
genre_facet |
saami |
op_relation |
https://www.ncbi.nlm.nih.gov/pubmed/28935946 Scientific Reports, 2017, 7 (1), 12086 2045-2322 https://www.nature.com/articles/s41598-017-11307-9 http://hdl.handle.net/2381/40469 doi:10.1038/s41598-017-11307-9 |
op_rights |
Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-017-11307-9 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
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1766180564152352768 |