LaGomiCs—Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order

The order Lagomorpha comprises about 90 living species, divided in 2 families: the pikas (Family Ochotonidae), and the rabbits, hares, and jackrabbits (Family Leporidae). Lagomorphs are important economically and scientifically as major human food resources, valued game species, pests of agricultura...

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Bibliographic Details
Published in:Journal of Heredity
Main Authors: Fontanesi, Luca, Di Palma, Federica, Flicek, Paul, Smith, Andrew T, Thulin, Carl-Gustaf, Alves, Paulo C, Fickel, Joerns, Lagomorph Genomics Consortium
Language:English
Published: 2015
Subjects:
International consortium
Sequencing data
White paper
Whole genome sequencing
Comperative genomics
Conservation genetics and biodiversity
Mammalian evolution
Molecular systematics and phylogenetics
Arctic
Antarc*
Antarctica
Online Access:https://repository.publisso.de/resource/frl:6407314
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888434/
https://doi.org/10.1093/jhered/esw010
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Summary:The order Lagomorpha comprises about 90 living species, divided in 2 families: the pikas (Family Ochotonidae), and the rabbits, hares, and jackrabbits (Family Leporidae). Lagomorphs are important economically and scientifically as major human food resources, valued game species, pests of agricultural significance, model laboratory animals, and key elements in food webs. A quarter of the lagomorph species are listed as threatened. They are native to all continents except Antarctica, and occur up to 5000 m above sea level, from the equator to the Arctic, spanning a wide range of environmental conditions. The order has notable taxonomic problems presenting significant difficulties for defining a species due to broad phenotypic variation, overlap of morphological characteristics, and relatively recent speciation events. At present, only the genomes of 2 species, the European rabbit (Oryctolagus cuniculus) and American pika (Ochotona princeps) have been sequenced and assembled. Starting from a paucity of genome information, the main scientific aim of the Lagomorph Genomics Consortium (LaGomiCs), born from a cooperative initiative of the European COST Action “A Collaborative European Network on Rabbit Genome Biology—RGB-Net” and the World Lagomorph Society (WLS), is to provide an international framework for the sequencing of the genome of all extant and selected extinct lagomorphs. Sequencing the genomes of an entire order will provide a large amount of information to address biological problems not only related to lagomorphs but also to all mammals. We present current and planned sequencing programs and outline the final objective of LaGomiCs possible through broad international collaboration.

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