Insights into the evolution of longevity from the bowhead whale genome
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bo...
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ftleedsuniv:oai:eprints.whiterose.ac.uk:103529 2023-05-15T15:35:58+02:00 Insights into the evolution of longevity from the bowhead whale genome Keane, M Semeiks, J Webb, AE Li, YI Quesada, V Craig, T Madsen, LB Van Dam, S Brawand, D Marques, PI Michalak, P Kang, L Bhak, J Yim, H-S Grishin, NV Nielsen, NH Heide-Jørgensen, MP Oziolor, EM Matson, CW Church, GM Stuart, GW Patton, JC George, JC Suydam, R Larsen, K López-Otín, C O'Connell, MJ Bickham, JW Thomsen, B De Magalhães, JP 2015-01-06 text https://eprints.whiterose.ac.uk/103529/ https://eprints.whiterose.ac.uk/103529/1/Insights%20into%20the%20evolution%20of%20longevity%20from%20the%20bowhead%20whale%20genome.pdf https://doi.org/10.1016/j.celrep.2014.12.008 en eng Elsevier https://eprints.whiterose.ac.uk/103529/1/Insights%20into%20the%20evolution%20of%20longevity%20from%20the%20bowhead%20whale%20genome.pdf Keane, M, Semeiks, J, Webb, AE et al. (27 more authors) (2015) Insights into the evolution of longevity from the bowhead whale genome. Cell Reports, 10 (1). pp. 112-122. ISSN 2211-1247 Article NonPeerReviewed 2015 ftleedsuniv https://doi.org/10.1016/j.celrep.2014.12.008 2023-01-30T21:45:14Z The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. Article in Journal/Newspaper Balaena mysticetus bowhead whale White Rose Research Online (Universities of Leeds, Sheffield & York) Cell Reports 10 1 112 122 |
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Open Polar |
collection |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
op_collection_id |
ftleedsuniv |
language |
English |
description |
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. |
format |
Article in Journal/Newspaper |
author |
Keane, M Semeiks, J Webb, AE Li, YI Quesada, V Craig, T Madsen, LB Van Dam, S Brawand, D Marques, PI Michalak, P Kang, L Bhak, J Yim, H-S Grishin, NV Nielsen, NH Heide-Jørgensen, MP Oziolor, EM Matson, CW Church, GM Stuart, GW Patton, JC George, JC Suydam, R Larsen, K López-Otín, C O'Connell, MJ Bickham, JW Thomsen, B De Magalhães, JP |
spellingShingle |
Keane, M Semeiks, J Webb, AE Li, YI Quesada, V Craig, T Madsen, LB Van Dam, S Brawand, D Marques, PI Michalak, P Kang, L Bhak, J Yim, H-S Grishin, NV Nielsen, NH Heide-Jørgensen, MP Oziolor, EM Matson, CW Church, GM Stuart, GW Patton, JC George, JC Suydam, R Larsen, K López-Otín, C O'Connell, MJ Bickham, JW Thomsen, B De Magalhães, JP Insights into the evolution of longevity from the bowhead whale genome |
author_facet |
Keane, M Semeiks, J Webb, AE Li, YI Quesada, V Craig, T Madsen, LB Van Dam, S Brawand, D Marques, PI Michalak, P Kang, L Bhak, J Yim, H-S Grishin, NV Nielsen, NH Heide-Jørgensen, MP Oziolor, EM Matson, CW Church, GM Stuart, GW Patton, JC George, JC Suydam, R Larsen, K López-Otín, C O'Connell, MJ Bickham, JW Thomsen, B De Magalhães, JP |
author_sort |
Keane, M |
title |
Insights into the evolution of longevity from the bowhead whale genome |
title_short |
Insights into the evolution of longevity from the bowhead whale genome |
title_full |
Insights into the evolution of longevity from the bowhead whale genome |
title_fullStr |
Insights into the evolution of longevity from the bowhead whale genome |
title_full_unstemmed |
Insights into the evolution of longevity from the bowhead whale genome |
title_sort |
insights into the evolution of longevity from the bowhead whale genome |
publisher |
Elsevier |
publishDate |
2015 |
url |
https://eprints.whiterose.ac.uk/103529/ https://eprints.whiterose.ac.uk/103529/1/Insights%20into%20the%20evolution%20of%20longevity%20from%20the%20bowhead%20whale%20genome.pdf https://doi.org/10.1016/j.celrep.2014.12.008 |
genre |
Balaena mysticetus bowhead whale |
genre_facet |
Balaena mysticetus bowhead whale |
op_relation |
https://eprints.whiterose.ac.uk/103529/1/Insights%20into%20the%20evolution%20of%20longevity%20from%20the%20bowhead%20whale%20genome.pdf Keane, M, Semeiks, J, Webb, AE et al. (27 more authors) (2015) Insights into the evolution of longevity from the bowhead whale genome. Cell Reports, 10 (1). pp. 112-122. ISSN 2211-1247 |
op_doi |
https://doi.org/10.1016/j.celrep.2014.12.008 |
container_title |
Cell Reports |
container_volume |
10 |
container_issue |
1 |
container_start_page |
112 |
op_container_end_page |
122 |
_version_ |
1766366313909846016 |