An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice
Kanta Chechi1, John J. Mcguire2 and Sukhinder K. Cheema1,21Department of Biochemistry and 2Division of BioMedical Sciences, Memorial University, St. John’s, Newfoundland, A1B 3X9, Canada. Abstract Aim: To investigate the effects of diets rich in n-6 polyunsaturated fats (PUFA) fed during pre- and po...
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ftlapress:oai:libertasacademica.com/2363 2023-05-15T17:22:26+02:00 An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice Cheema Kanta Chechi, John J. Mcguire and Sukhinder K. Cheema 2010-11-22 PDF http://www.la-press.com/redirect_file.php?fileId=3227&filename=2363-NMI-An-Interaction-of-the-Pre--and-Post-Weaning-Diets-Rich-in-Omega-6--Pol.pdf&fileType=pdf English eng Libertas Academica http://www.la-press.com/an-interaction-of-the-pre--and-post-weaning-diets-rich-in-omega-6--pol-article-a2363 Nutrition and Metabolic Insights Volume: 2010 Issue: 3 2010 ftlapress 2016-10-16T19:48:47Z Kanta Chechi1, John J. Mcguire2 and Sukhinder K. Cheema1,21Department of Biochemistry and 2Division of BioMedical Sciences, Memorial University, St. John’s, Newfoundland, A1B 3X9, Canada. Abstract Aim: To investigate the effects of diets rich in n-6 polyunsaturated fats (PUFA) fed during pre- and post-weaning time periods on the lipid metabolism and vascular reactivity in adult C57Bl/6 mice, in order to assess the impact of maternal nutrition and its interaction with the offspring diet on the metabolism of adult offspring.Methods: Female C57Bl/6 mice were fed a high-fat diet enriched with n-6 PUFA (P) or control diet (C) for 2-weeks before, during mating, gestation and lactation, while their pups received either P or C for 8-weeks post-weaning.Results: A significant interaction between the maternal and post-weaning diets was observed for the offspring body weight, food-, caloric-intake, plasma lipids, hepatic mRNA expression of lecithin cholesterol acyltransferase, aortic contractile and relaxation responses (P < 0.05).Conclusion: The overall metabolic and physiological outcome in the offspring is dependent upon the interaction between the pre- and post-weaning dietary environments. Other/Unknown Material Newfoundland Libertas Academica (Open Access Peer Reviewed Medical Journals) Canada |
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Libertas Academica (Open Access Peer Reviewed Medical Journals) |
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English |
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Nutrition and Metabolic Insights Volume: 2010 Issue: 3 |
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Nutrition and Metabolic Insights Volume: 2010 Issue: 3 Cheema An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
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Nutrition and Metabolic Insights Volume: 2010 Issue: 3 |
description |
Kanta Chechi1, John J. Mcguire2 and Sukhinder K. Cheema1,21Department of Biochemistry and 2Division of BioMedical Sciences, Memorial University, St. John’s, Newfoundland, A1B 3X9, Canada. Abstract Aim: To investigate the effects of diets rich in n-6 polyunsaturated fats (PUFA) fed during pre- and post-weaning time periods on the lipid metabolism and vascular reactivity in adult C57Bl/6 mice, in order to assess the impact of maternal nutrition and its interaction with the offspring diet on the metabolism of adult offspring.Methods: Female C57Bl/6 mice were fed a high-fat diet enriched with n-6 PUFA (P) or control diet (C) for 2-weeks before, during mating, gestation and lactation, while their pups received either P or C for 8-weeks post-weaning.Results: A significant interaction between the maternal and post-weaning diets was observed for the offspring body weight, food-, caloric-intake, plasma lipids, hepatic mRNA expression of lecithin cholesterol acyltransferase, aortic contractile and relaxation responses (P < 0.05).Conclusion: The overall metabolic and physiological outcome in the offspring is dependent upon the interaction between the pre- and post-weaning dietary environments. |
author2 |
Kanta Chechi, John J. Mcguire and Sukhinder K. Cheema |
author |
Cheema |
author_facet |
Cheema |
author_sort |
Cheema |
title |
An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
title_short |
An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
title_full |
An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
title_fullStr |
An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
title_full_unstemmed |
An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice |
title_sort |
interaction of the pre- and post-weaning diets rich in omega-6 polyunsaturated fats alters plasma lipids, hepatic gene expression and aortic vascular reactivity in adult c57bl/6 mice |
publisher |
Libertas Academica |
publishDate |
2010 |
url |
http://www.la-press.com/redirect_file.php?fileId=3227&filename=2363-NMI-An-Interaction-of-the-Pre--and-Post-Weaning-Diets-Rich-in-Omega-6--Pol.pdf&fileType=pdf |
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Canada |
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Canada |
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Newfoundland |
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Newfoundland |
op_source |
http://www.la-press.com/an-interaction-of-the-pre--and-post-weaning-diets-rich-in-omega-6--pol-article-a2363 |
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1766109096914714624 |