Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND PURPOSE: Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atheros...
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Online Access: | http://hdl.handle.net/2336/99815 https://doi.org/10.1161/STROKEAHA.110.579581 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/99815 2023-05-15T16:52:20+02:00 Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study Vidal, Jean-Sébastien Sigurdsson, Sigurdur Jonsdottir, Maria K Eiriksdottir, Gudny Thorgeirsson, Gudmundur Kjartansson, Olafur Garcia, Melissa E van Buchem, Mark A Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J National Institutes of Health, NIA/LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892-9205, USA. 2010-05-25 http://hdl.handle.net/2336/99815 https://doi.org/10.1161/STROKEAHA.110.579581 en eng Lippincott Williams & Wilkins http://dx.doi.org/10.1161/STROKEAHA.110.579581 Stroke. 2010, 41(5):891-7 1524-4628 20360538 doi:10.1161/STROKEAHA.110.579581 http://hdl.handle.net/2336/99815 Stroke; a journal of cerebral circulation Aged 80 and over Aging Brain Calcinosis Cognition Disorders Cohort Studies Coronary Artery Disease Coronary Vessels Cross-Sectional Studies Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Article 2010 ftlandspitaliuni https://doi.org/10.1161/STROKEAHA.110.579581 2022-05-29T08:21:32Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND PURPOSE: Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. METHODS: This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. RESULTS: Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. CONCLUSIONS: In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Stroke 41 5 891 897 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Aging Brain Calcinosis Cognition Disorders Cohort Studies Coronary Artery Disease Coronary Vessels Cross-Sectional Studies Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male |
spellingShingle |
Aged 80 and over Aging Brain Calcinosis Cognition Disorders Cohort Studies Coronary Artery Disease Coronary Vessels Cross-Sectional Studies Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male Vidal, Jean-Sébastien Sigurdsson, Sigurdur Jonsdottir, Maria K Eiriksdottir, Gudny Thorgeirsson, Gudmundur Kjartansson, Olafur Garcia, Melissa E van Buchem, Mark A Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
topic_facet |
Aged 80 and over Aging Brain Calcinosis Cognition Disorders Cohort Studies Coronary Artery Disease Coronary Vessels Cross-Sectional Studies Environment Female Genetic Predisposition to Disease Humans Iceland Magnetic Resonance Imaging Male |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND PURPOSE: Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. METHODS: This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. RESULTS: Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. CONCLUSIONS: In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology. |
author2 |
National Institutes of Health, NIA/LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892-9205, USA. |
format |
Article in Journal/Newspaper |
author |
Vidal, Jean-Sébastien Sigurdsson, Sigurdur Jonsdottir, Maria K Eiriksdottir, Gudny Thorgeirsson, Gudmundur Kjartansson, Olafur Garcia, Melissa E van Buchem, Mark A Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J |
author_facet |
Vidal, Jean-Sébastien Sigurdsson, Sigurdur Jonsdottir, Maria K Eiriksdottir, Gudny Thorgeirsson, Gudmundur Kjartansson, Olafur Garcia, Melissa E van Buchem, Mark A Harris, Tamara B Gudnason, Vilmundur Launer, Lenore J |
author_sort |
Vidal, Jean-Sébastien |
title |
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
title_short |
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
title_full |
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
title_fullStr |
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
title_full_unstemmed |
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study |
title_sort |
coronary artery calcium, brain function and structure: the ages-reykjavik study |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/99815 https://doi.org/10.1161/STROKEAHA.110.579581 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1161/STROKEAHA.110.579581 Stroke. 2010, 41(5):891-7 1524-4628 20360538 doi:10.1161/STROKEAHA.110.579581 http://hdl.handle.net/2336/99815 Stroke; a journal of cerebral circulation |
op_doi |
https://doi.org/10.1161/STROKEAHA.110.579581 |
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Stroke |
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41 |
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5 |
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891 |
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897 |
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