Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) OBJECTIVE: To study the impact of TNM stage and various preoperative functional parameters on survival in patients who underwent lobectomy for non-small cell lung cancer (NSCLC) in Iceland fr...
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Læknafélag Íslands, Læknafélag Reykjavíkur
2010
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Online Access: | http://hdl.handle.net/2336/99096 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/99096 2023-05-15T16:47:14+02:00 Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 Factors predictive of survival after lobectomy for non-small cell lung cancer in Iceland during 1999-2008 Guðrún Nína Óskarsdóttir Rut Skúladóttir Helgi J. Ísaksson Steinn Jónsson Húnbogi Þorsteinsson Tómas Guðbjartsson 2010-05-18 http://hdl.handle.net/2336/99096 ice is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 2010, 96(4):251-7 0023-7213 20339164 http://hdl.handle.net/2336/99096 Læknablaðið Lungnakrabbamein Adenocarcinoma Aged Carcinoma Non-Small-Cell Lung Female Forced Expiratory Volume Humans Iceland Kaplan-Meiers Estimate Lung Neoplasms Male Neoplasm Staging Outcome and Process Assessment (Health Care) Pneumonectomy Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Article 2010 ftlandspitaliuni 2022-05-29T08:21:32Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) OBJECTIVE: To study the impact of TNM stage and various preoperative functional parameters on survival in patients who underwent lobectomy for non-small cell lung cancer (NSCLC) in Iceland from 1999 to 2008. MATERIALS AND METHODS: Retrospective study including 213 patients (mean age 66.9 yrs, equal male/female ratio) that underwent lobectomy for NSCLC. Tumors were staged by the TNM staging system, survival was estimated by the Kaplan-Meier method and prognostic factors of survival studied using the Cox proportional hazards regression model. RESULTS: Survival at 1 year was 82.7% and 45.1% at 5 years. Operative mortality at 30 days was 0%. Most tumors were found to be in stage I (59.6%) or stage II (17.8%) and 7% were stage IIIA, whereas 14.6% were in stage IIIB or IV. Using multivariate analysis; advancing stage, increasing tumor size, reduced lung function and history of arrhythmia, predicted worse survival, whereas adenocarcinoma histology was a positive prognostic factor (HR 0.5, p=0.002) when compared to other histological types. CONCLUSIONS: Survival for patients undergoing lobectomy for operable non-small cell lung cancer in Iceland is comparable with other studies. Advanced stage, tumor size, reduced lung function and arrhythmia were negative predictors of survival, but in contrast to many but not all studies adenocarcinoma histology predicted a better prognosis compared to other tumor types. Inngangur: Skurðaðgerð er helsta læknandi meðferð við lungnakrabbameini. Tilgangur þessarar rannsóknar var að kanna stigun, lífshorfur og forspárþætti lífshorfa hjá sjúklingum sem gengist hafa undir lungnablaðnám vegna lungnakrabbameins á Íslandi. Efniviður og aðferðir: Afturskyggn rannsókn á 213 sjúklingum (meðalaldur 66,9 ár) sem gengust undir blaðnám á Íslandi við lungnakrabbameini öðru en smáfrumukrabbameini (ÖES) á tímabilinu 1999-2008. Æxlin voru stiguð samkvæmt TNM-stigunarkerfi og ein- og ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Lungnakrabbamein Adenocarcinoma Aged Carcinoma Non-Small-Cell Lung Female Forced Expiratory Volume Humans Iceland Kaplan-Meiers Estimate Lung Neoplasms Male Neoplasm Staging Outcome and Process Assessment (Health Care) Pneumonectomy Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
spellingShingle |
Lungnakrabbamein Adenocarcinoma Aged Carcinoma Non-Small-Cell Lung Female Forced Expiratory Volume Humans Iceland Kaplan-Meiers Estimate Lung Neoplasms Male Neoplasm Staging Outcome and Process Assessment (Health Care) Pneumonectomy Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Guðrún Nína Óskarsdóttir Rut Skúladóttir Helgi J. Ísaksson Steinn Jónsson Húnbogi Þorsteinsson Tómas Guðbjartsson Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
topic_facet |
Lungnakrabbamein Adenocarcinoma Aged Carcinoma Non-Small-Cell Lung Female Forced Expiratory Volume Humans Iceland Kaplan-Meiers Estimate Lung Neoplasms Male Neoplasm Staging Outcome and Process Assessment (Health Care) Pneumonectomy Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) OBJECTIVE: To study the impact of TNM stage and various preoperative functional parameters on survival in patients who underwent lobectomy for non-small cell lung cancer (NSCLC) in Iceland from 1999 to 2008. MATERIALS AND METHODS: Retrospective study including 213 patients (mean age 66.9 yrs, equal male/female ratio) that underwent lobectomy for NSCLC. Tumors were staged by the TNM staging system, survival was estimated by the Kaplan-Meier method and prognostic factors of survival studied using the Cox proportional hazards regression model. RESULTS: Survival at 1 year was 82.7% and 45.1% at 5 years. Operative mortality at 30 days was 0%. Most tumors were found to be in stage I (59.6%) or stage II (17.8%) and 7% were stage IIIA, whereas 14.6% were in stage IIIB or IV. Using multivariate analysis; advancing stage, increasing tumor size, reduced lung function and history of arrhythmia, predicted worse survival, whereas adenocarcinoma histology was a positive prognostic factor (HR 0.5, p=0.002) when compared to other histological types. CONCLUSIONS: Survival for patients undergoing lobectomy for operable non-small cell lung cancer in Iceland is comparable with other studies. Advanced stage, tumor size, reduced lung function and arrhythmia were negative predictors of survival, but in contrast to many but not all studies adenocarcinoma histology predicted a better prognosis compared to other tumor types. Inngangur: Skurðaðgerð er helsta læknandi meðferð við lungnakrabbameini. Tilgangur þessarar rannsóknar var að kanna stigun, lífshorfur og forspárþætti lífshorfa hjá sjúklingum sem gengist hafa undir lungnablaðnám vegna lungnakrabbameins á Íslandi. Efniviður og aðferðir: Afturskyggn rannsókn á 213 sjúklingum (meðalaldur 66,9 ár) sem gengust undir blaðnám á Íslandi við lungnakrabbameini öðru en smáfrumukrabbameini (ÖES) á tímabilinu 1999-2008. Æxlin voru stiguð samkvæmt TNM-stigunarkerfi og ein- og ... |
format |
Article in Journal/Newspaper |
author |
Guðrún Nína Óskarsdóttir Rut Skúladóttir Helgi J. Ísaksson Steinn Jónsson Húnbogi Þorsteinsson Tómas Guðbjartsson |
author_facet |
Guðrún Nína Óskarsdóttir Rut Skúladóttir Helgi J. Ísaksson Steinn Jónsson Húnbogi Þorsteinsson Tómas Guðbjartsson |
author_sort |
Guðrún Nína Óskarsdóttir |
title |
Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
title_short |
Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
title_full |
Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
title_fullStr |
Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
title_full_unstemmed |
Forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á Íslandi 1999-2008 |
title_sort |
forspárþættir lífshorfa eftir blaðnám við lungnakrabbameini á íslandi 1999-2008 |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/99096 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) ENVELOPE(-58.100,-58.100,-62.000,-62.000) ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Meier TNM Smella |
geographic_facet |
Meier TNM Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 2010, 96(4):251-7 0023-7213 20339164 http://hdl.handle.net/2336/99096 Læknablaðið |
_version_ |
1766037312924286976 |