Several common variants modulate heart rate, PR interval and QRS duration
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in indi...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/96605 https://doi.org/10.1038/ng.511 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/96605 2023-05-15T16:50:41+02:00 Several common variants modulate heart rate, PR interval and QRS duration Holm, Hilma Gudbjartsson, Daniel F Arnar, David O Thorleifsson, Gudmar Thorgeirsson, Gudmundur Stefansdottir, Hrafnhildur Gudjonsson, Sigurjon A Jonasdottir, Aslaug Mathiesen, Ellisiv B Njølstad, Inger Nyrnes, Audhild Wilsgaard, Tom Hald, Erin M Hveem, Kristian Stoltenberg, Camilla Løchen, Maja-Lisa Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari deCODE genetics, Reykjavik, Iceland. hilma.holm@decode.is 2010-04-15 http://hdl.handle.net/2336/96605 https://doi.org/10.1038/ng.511 en eng Nature Pub. Co. http://dx.doi.org/10.1038/ng.511 Nat. Genet. 2010, 42(2):117-22 1546-1718 20062063 doi:10.1038/ng.511 http://hdl.handle.net/2336/96605 Nature genetics Aged Arrhythmias Cardiac Atrial Fibrillation Atrioventricular Block Cardiac Myosins Electrocardiography Female Genetic Loci Genetic Variation Genome-Wide Association Study Heart Conduction System Heart Rate Iceland Inheritance Patterns Male Middle Aged Myosin Heavy Chains Pacemaker Artificial Reproducibility of Results Sick Sinus Syndrome Article 2010 ftlandspitaliuni https://doi.org/10.1038/ng.511 2022-05-29T08:21:31Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21). We tested for association between these loci and subjects with selected arrhythmias in Icelandic and Norwegian case-control sample sets. We observed correlations between TBX5 and CAV1 and atrial fibrillation (P = 4.0 x 10(-5) and P = 0.00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 42 2 117 122 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged Arrhythmias Cardiac Atrial Fibrillation Atrioventricular Block Cardiac Myosins Electrocardiography Female Genetic Loci Genetic Variation Genome-Wide Association Study Heart Conduction System Heart Rate Iceland Inheritance Patterns Male Middle Aged Myosin Heavy Chains Pacemaker Artificial Reproducibility of Results Sick Sinus Syndrome |
spellingShingle |
Aged Arrhythmias Cardiac Atrial Fibrillation Atrioventricular Block Cardiac Myosins Electrocardiography Female Genetic Loci Genetic Variation Genome-Wide Association Study Heart Conduction System Heart Rate Iceland Inheritance Patterns Male Middle Aged Myosin Heavy Chains Pacemaker Artificial Reproducibility of Results Sick Sinus Syndrome Holm, Hilma Gudbjartsson, Daniel F Arnar, David O Thorleifsson, Gudmar Thorgeirsson, Gudmundur Stefansdottir, Hrafnhildur Gudjonsson, Sigurjon A Jonasdottir, Aslaug Mathiesen, Ellisiv B Njølstad, Inger Nyrnes, Audhild Wilsgaard, Tom Hald, Erin M Hveem, Kristian Stoltenberg, Camilla Løchen, Maja-Lisa Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari Several common variants modulate heart rate, PR interval and QRS duration |
topic_facet |
Aged Arrhythmias Cardiac Atrial Fibrillation Atrioventricular Block Cardiac Myosins Electrocardiography Female Genetic Loci Genetic Variation Genome-Wide Association Study Heart Conduction System Heart Rate Iceland Inheritance Patterns Male Middle Aged Myosin Heavy Chains Pacemaker Artificial Reproducibility of Results Sick Sinus Syndrome |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21). We tested for association between these loci and subjects with selected arrhythmias in Icelandic and Norwegian case-control sample sets. We observed correlations between TBX5 and CAV1 and atrial fibrillation (P = 4.0 x 10(-5) and P = 0.00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval. |
author2 |
deCODE genetics, Reykjavik, Iceland. hilma.holm@decode.is |
format |
Article in Journal/Newspaper |
author |
Holm, Hilma Gudbjartsson, Daniel F Arnar, David O Thorleifsson, Gudmar Thorgeirsson, Gudmundur Stefansdottir, Hrafnhildur Gudjonsson, Sigurjon A Jonasdottir, Aslaug Mathiesen, Ellisiv B Njølstad, Inger Nyrnes, Audhild Wilsgaard, Tom Hald, Erin M Hveem, Kristian Stoltenberg, Camilla Løchen, Maja-Lisa Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari |
author_facet |
Holm, Hilma Gudbjartsson, Daniel F Arnar, David O Thorleifsson, Gudmar Thorgeirsson, Gudmundur Stefansdottir, Hrafnhildur Gudjonsson, Sigurjon A Jonasdottir, Aslaug Mathiesen, Ellisiv B Njølstad, Inger Nyrnes, Audhild Wilsgaard, Tom Hald, Erin M Hveem, Kristian Stoltenberg, Camilla Løchen, Maja-Lisa Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari |
author_sort |
Holm, Hilma |
title |
Several common variants modulate heart rate, PR interval and QRS duration |
title_short |
Several common variants modulate heart rate, PR interval and QRS duration |
title_full |
Several common variants modulate heart rate, PR interval and QRS duration |
title_fullStr |
Several common variants modulate heart rate, PR interval and QRS duration |
title_full_unstemmed |
Several common variants modulate heart rate, PR interval and QRS duration |
title_sort |
several common variants modulate heart rate, pr interval and qrs duration |
publisher |
Nature Pub. Co. |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/96605 https://doi.org/10.1038/ng.511 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ng.511 Nat. Genet. 2010, 42(2):117-22 1546-1718 20062063 doi:10.1038/ng.511 http://hdl.handle.net/2336/96605 Nature genetics |
op_doi |
https://doi.org/10.1038/ng.511 |
container_title |
Nature Genetics |
container_volume |
42 |
container_issue |
2 |
container_start_page |
117 |
op_container_end_page |
122 |
_version_ |
1766040804660346880 |