Lifrarskaði tengdur notkun á Herbalife
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Objective: Many herbal products are known to be hepatotoxic. In a recent survey in Iceland concerning adverse reactions related to herbal medicines, Herbalife products were implicated in the...
Main Authors: | , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | Icelandic |
Published: |
Læknafélag Íslands, Læknafélag Reykjavíkur
2010
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/94243 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/94243 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/94243 2023-05-15T16:52:47+02:00 Lifrarskaði tengdur notkun á Herbalife Hepatotoxicity associated with the use of Herbalife Magnús Jóhannsson Sif Ormarsdóttir Sigurður Ólafsson 2010-03-15 http://hdl.handle.net/2336/94243 ICE is ice Læknafélag Íslands, Læknafélag Reykjavíkur http://www.laeknabladid.is Læknablaðið 2010, 96(3):167-72 0023-7213 20197595 http://hdl.handle.net/2336/94243 Læknablaðið Fæðubótarefni Lyf Lifrarsjúkdómar Herbalife [Substance Name] Drug-Induced Liver Injury Article 2010 ftlandspitaliuni 2022-05-29T08:21:30Z Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Objective: Many herbal products are known to be hepatotoxic. In a recent survey in Iceland concerning adverse reactions related to herbal medicines, Herbalife products were implicated in the majority of the reported cases of hepatotoxicity. Methods: The clinical presentations of five cases of Herbalife related liver injury during the period of 1999-2008 are analysed. Causality was assessed by using the WHO-UMC system for causality assessment and the RUCAM method. Results: Of the five cases there were four females and one male; median age was 46 years (range 29-78). Herbalife had been used for 1 to 7 months prior to presentation. Four patients presented with a hepatocellular and one with a cholestatic reaction. Median values were for bilirubin 190 mmol/L (range: 26-311; ref. < 20 mmol/L), ALP 407 U/L (range: 149-712; ref. 35-105 U/L) and ALT 24 87 U/L (range: 456-2637; ref. 70 and 45 U/L for males and females, respectively). Liver biopsy was performed in 2 patients and was consistent with toxic hepatitis in both cases. Other causes of hepatitis were excluded by appropriate serological testing and ultrasound. Causality assessment according to RUCAM was probable in three cases and possible in two. Using the WHO-UMC criteria causality was certain in one case, probable in two and possible in two cases. Conclusions: Hepatotoxicity is probably associated with the use of Herbalife products. Hepatotoxicity due to herbal remedies is an important differential diagnosis in the diagnostic work-up of liver injury. Tilgangur: Mörg náttúruefni eru þekkt að því að geta valdið lifrarskaða. Nýleg íslensk könnun á aukaverkunum náttúruefna sýndi að lifrarskaði var oftast tengdur notkun Herbalife. Aðferðir: Lýst er fimm tilfellum af eitrunarlifrarbólgu í tengslum við notkun á ýmsum Herbalifevörum á Íslandi á árunum 1999 til 2008. Orsakatengsl voru metin með skilmerkjum WHO-UMC en einnig með RUCAM aðferðinni. ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
Icelandic |
topic |
Fæðubótarefni Lyf Lifrarsjúkdómar Herbalife [Substance Name] Drug-Induced Liver Injury |
spellingShingle |
Fæðubótarefni Lyf Lifrarsjúkdómar Herbalife [Substance Name] Drug-Induced Liver Injury Magnús Jóhannsson Sif Ormarsdóttir Sigurður Ólafsson Lifrarskaði tengdur notkun á Herbalife |
topic_facet |
Fæðubótarefni Lyf Lifrarsjúkdómar Herbalife [Substance Name] Drug-Induced Liver Injury |
description |
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Objective: Many herbal products are known to be hepatotoxic. In a recent survey in Iceland concerning adverse reactions related to herbal medicines, Herbalife products were implicated in the majority of the reported cases of hepatotoxicity. Methods: The clinical presentations of five cases of Herbalife related liver injury during the period of 1999-2008 are analysed. Causality was assessed by using the WHO-UMC system for causality assessment and the RUCAM method. Results: Of the five cases there were four females and one male; median age was 46 years (range 29-78). Herbalife had been used for 1 to 7 months prior to presentation. Four patients presented with a hepatocellular and one with a cholestatic reaction. Median values were for bilirubin 190 mmol/L (range: 26-311; ref. < 20 mmol/L), ALP 407 U/L (range: 149-712; ref. 35-105 U/L) and ALT 24 87 U/L (range: 456-2637; ref. 70 and 45 U/L for males and females, respectively). Liver biopsy was performed in 2 patients and was consistent with toxic hepatitis in both cases. Other causes of hepatitis were excluded by appropriate serological testing and ultrasound. Causality assessment according to RUCAM was probable in three cases and possible in two. Using the WHO-UMC criteria causality was certain in one case, probable in two and possible in two cases. Conclusions: Hepatotoxicity is probably associated with the use of Herbalife products. Hepatotoxicity due to herbal remedies is an important differential diagnosis in the diagnostic work-up of liver injury. Tilgangur: Mörg náttúruefni eru þekkt að því að geta valdið lifrarskaða. Nýleg íslensk könnun á aukaverkunum náttúruefna sýndi að lifrarskaði var oftast tengdur notkun Herbalife. Aðferðir: Lýst er fimm tilfellum af eitrunarlifrarbólgu í tengslum við notkun á ýmsum Herbalifevörum á Íslandi á árunum 1999 til 2008. Orsakatengsl voru metin með skilmerkjum WHO-UMC en einnig með RUCAM aðferðinni. ... |
format |
Article in Journal/Newspaper |
author |
Magnús Jóhannsson Sif Ormarsdóttir Sigurður Ólafsson |
author_facet |
Magnús Jóhannsson Sif Ormarsdóttir Sigurður Ólafsson |
author_sort |
Magnús Jóhannsson |
title |
Lifrarskaði tengdur notkun á Herbalife |
title_short |
Lifrarskaði tengdur notkun á Herbalife |
title_full |
Lifrarskaði tengdur notkun á Herbalife |
title_fullStr |
Lifrarskaði tengdur notkun á Herbalife |
title_full_unstemmed |
Lifrarskaði tengdur notkun á Herbalife |
title_sort |
lifrarskaði tengdur notkun á herbalife |
publisher |
Læknafélag Íslands, Læknafélag Reykjavíkur |
publishDate |
2010 |
url |
http://hdl.handle.net/2336/94243 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) |
geographic |
Smella |
geographic_facet |
Smella |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.laeknabladid.is Læknablaðið 2010, 96(3):167-72 0023-7213 20197595 http://hdl.handle.net/2336/94243 Læknablaðið |
_version_ |
1766043180257509376 |