Algengi hjartavöðvaþykknunar meðal karla á Íslandi

• Main Authors: Uggi Agnarsson, Þórður Harðarson, Jónas Hallgrímsson, Nikulás Sigfússon
• Format: Other/Unknown Material
• Language: Icelandic
• Published: Læknafélag Íslands, Læknafélag Reykjavíkur 2009
• Subjects: Hjartasjúkdómar; Cardiomyopathy; Hypertrophic; Iceland/epidemiology; Male; Smella; Iceland
• Online Access: http://hdl.handle.net/2336/85056

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open This study was designed to assess the prevalence of hypertrophic cardiomyopathy in a population sample of 3607 adult Icelandic men previously screened for cardiac risk factors. In this population 3155 men had a normal and 452 (group A) had an abnormal electrocardiogram. We used 2D-and M-mode echocardiography, reviewed and reexamined autopsy records of men from this cohort to identify men with hypertrophic cardiomyopathy. All men in group A as well as an echocardiographic control (group B) (n=128) with a normal original electrocardiogram were subjects of this study. The prevalence of hypertrophic cardiomyopathy among men with an abnormal electrocardiogram was 3.6%, and 0.8% among men with a normal electrocardiogram. During the 8 year interval between this study and the original screening (Reykjavik) study 59 of the 452 men in group A died, two of whom had hypertrophic cardiomyopathy diagnosed at autopsy. Among all men with a normal electrocardiogram there had been 130 deaths, two of whom had hypertrophic cardiomyopathy at autopsy. The annual mortality rate among men with hypertrophic cardiomyopathy in this population is 1.6% versus 0.5% among men with a normal (p<0.001) and 1.7% among men with an abnormal electrocardiogram (NS) in the absence of hypertrophic cardiomyopathy. Among the echo control group B we did not find any cases of hypertrophic cardiomyopathy. We estimated 41 case of hypertrophic cardiomyopathy among the 3607 men in the Reykjavik study and the overall calculated prevalence of hypertrophic cardiomyopathy was 1.1% with a 95% confidence interval of 0.3-3.2%. Men with hypertrophic cardiomyopathy more often reported angina (50%) and dyspnea (42%) than the other groups (p<0.05-0.001) where hypertrophic cardiomyopathy was not found, 25% were without symptoms and 45% had asymptomatic ventricular arrhythmias as determined by 24-hour ambulatory monitoring. Hjartavöðvaþykknun (cardiomyopathia ...