A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and...
Published in: | Human Molecular Genetics |
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IRL Press at Oxford University Press
2009
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Online Access: | http://hdl.handle.net/2336/84473 https://doi.org/10.1093/hmg/8.9.1799 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/84473 2023-05-15T16:50:09+02:00 A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 Arngrimsson, R Sigurardottir, S Frigge, M L Bjarnad ttir, R I Jonsson, T Stefansson, H Baldursdottir, A Einarsdottir, A S Palsson, B Snorradottir, S Lachmeijer, A M Nicolae, D Kong, A Bragason, B T Gulcher, J R Geirsson, R T Stefansson, K Medical Genetics Unit, Faculty of Medicine, University of Iceland, Medical School Building, Vatnsmrarvegur, 101 Reykjavík, Iceland. 2009-10-20 http://hdl.handle.net/2336/84473 https://doi.org/10.1093/hmg/8.9.1799 en eng IRL Press at Oxford University Press http://dx.doi.org/10.1093/hmg/8.9.1799 Hum. Mol. Genet. 1999, 8(9):1799-805 0964-6906 10441346 doi:10.1093/hmg/8.9.1799 http://hdl.handle.net/2336/84473 1460-2083 Human molecular genetics Chromosome Mapping Chromosomes Human Pair 2 Female Genetic Markers Genetic Predisposition to Disease Genome Genotype Haplotypes Humans Iceland Linkage (Genetics) Lod Score Pedigree Pre-Eclampsia Pregnancy Article 2009 ftlandspitaliuni https://doi.org/10.1093/hmg/8.9.1799 2022-05-29T08:21:26Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10(-6)). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Human Molecular Genetics 8 9 1799 1805 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Chromosome Mapping Chromosomes Human Pair 2 Female Genetic Markers Genetic Predisposition to Disease Genome Genotype Haplotypes Humans Iceland Linkage (Genetics) Lod Score Pedigree Pre-Eclampsia Pregnancy |
spellingShingle |
Chromosome Mapping Chromosomes Human Pair 2 Female Genetic Markers Genetic Predisposition to Disease Genome Genotype Haplotypes Humans Iceland Linkage (Genetics) Lod Score Pedigree Pre-Eclampsia Pregnancy Arngrimsson, R Sigurardottir, S Frigge, M L Bjarnad ttir, R I Jonsson, T Stefansson, H Baldursdottir, A Einarsdottir, A S Palsson, B Snorradottir, S Lachmeijer, A M Nicolae, D Kong, A Bragason, B T Gulcher, J R Geirsson, R T Stefansson, K A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
topic_facet |
Chromosome Mapping Chromosomes Human Pair 2 Female Genetic Markers Genetic Predisposition to Disease Genome Genotype Haplotypes Humans Iceland Linkage (Genetics) Lod Score Pedigree Pre-Eclampsia Pregnancy |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10(-6)). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance. |
author2 |
Medical Genetics Unit, Faculty of Medicine, University of Iceland, Medical School Building, Vatnsmrarvegur, 101 Reykjavík, Iceland. |
format |
Article in Journal/Newspaper |
author |
Arngrimsson, R Sigurardottir, S Frigge, M L Bjarnad ttir, R I Jonsson, T Stefansson, H Baldursdottir, A Einarsdottir, A S Palsson, B Snorradottir, S Lachmeijer, A M Nicolae, D Kong, A Bragason, B T Gulcher, J R Geirsson, R T Stefansson, K |
author_facet |
Arngrimsson, R Sigurardottir, S Frigge, M L Bjarnad ttir, R I Jonsson, T Stefansson, H Baldursdottir, A Einarsdottir, A S Palsson, B Snorradottir, S Lachmeijer, A M Nicolae, D Kong, A Bragason, B T Gulcher, J R Geirsson, R T Stefansson, K |
author_sort |
Arngrimsson, R |
title |
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
title_short |
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
title_full |
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
title_fullStr |
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
title_full_unstemmed |
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
title_sort |
genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13 |
publisher |
IRL Press at Oxford University Press |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/84473 https://doi.org/10.1093/hmg/8.9.1799 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1093/hmg/8.9.1799 Hum. Mol. Genet. 1999, 8(9):1799-805 0964-6906 10441346 doi:10.1093/hmg/8.9.1799 http://hdl.handle.net/2336/84473 1460-2083 Human molecular genetics |
op_doi |
https://doi.org/10.1093/hmg/8.9.1799 |
container_title |
Human Molecular Genetics |
container_volume |
8 |
container_issue |
9 |
container_start_page |
1799 |
op_container_end_page |
1805 |
_version_ |
1766040335540027392 |