Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To examine the 5-year incidence of pseudoexfoliation (PEX) and monitor changes in related ophthalmologic variables. DESIGN: Population-based, prospective cohort study. METHODS: A r...
Published in: | American Journal of Ophthalmology |
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Online Access: | http://hdl.handle.net/2336/81094 https://doi.org/10.1016/j.ajo.2009.03.021 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/81094 2023-05-15T16:48:44+02:00 Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. Arnarsson, Arsaell Damji, Karim F Sasaki, Hiroshi Sverrisson, Thordur Jonasson, Fridbert Department of Ophthalmology, University of Iceland, Reykjavik, Iceland. 2009-09-15 http://hdl.handle.net/2336/81094 https://doi.org/10.1016/j.ajo.2009.03.021 en eng Elsevier Science http://dx.doi.org/10.1016/j.ajo.2009.03.021 Am. J. Ophthalmol. 2009, 148(2):291-7 1879-1891 19427619 doi:10.1016/j.ajo.2009.03.021 http://hdl.handle.net/2336/81094 American journal of ophthalmology Age Distribution Aged 80 and over Exfoliation Syndrome Female Follow-Up Studies Humans Iceland Incidence Intraocular Pressure Male Middle Aged Prospective Studies Sex Distribution Article 2009 ftlandspitaliuni https://doi.org/10.1016/j.ajo.2009.03.021 2022-05-29T08:21:24Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To examine the 5-year incidence of pseudoexfoliation (PEX) and monitor changes in related ophthalmologic variables. DESIGN: Population-based, prospective cohort study. METHODS: A random sample from the Reykjavik Population Census for persons 50 years and older was used. At baseline 1,045 participants were examined for signs of PEX including peripheral band and/or central shield of exfoliative material on the anterior lens capsule. Five years later, 846 (88.2%) of survivors returned for a follow-up visit. RESULTS: The 5-year incidence of PEX was 3.5% in right eyes only, and 5.2% in either eye. Age increased the risk of 5-year incidence by 5% when looking at 10-year age groups (P = .02); the incidence was higher in female subjects (P = .05) than in male. A total of 27% of clinically asymmetric cases converted to clinically bilateral disease over 5 years. Intraocular pressure increased in the group that developed PEX during the 5 years, but the size of the optic cup increased most in eyes that already had PEX at baseline. CONCLUSION: This incidence study from Iceland confirms findings from previous prevalence studies that PEX is increasingly common with older age in this population. Earliest changes related to PEX may be subtle and difficult to detect, which may lead to some misclassification. Further study is needed to identify clinical features that can reliably detect patients at risk for developing PEX. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Ophthalmology 148 2 291 297 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Age Distribution Aged 80 and over Exfoliation Syndrome Female Follow-Up Studies Humans Iceland Incidence Intraocular Pressure Male Middle Aged Prospective Studies Sex Distribution |
spellingShingle |
Age Distribution Aged 80 and over Exfoliation Syndrome Female Follow-Up Studies Humans Iceland Incidence Intraocular Pressure Male Middle Aged Prospective Studies Sex Distribution Arnarsson, Arsaell Damji, Karim F Sasaki, Hiroshi Sverrisson, Thordur Jonasson, Fridbert Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
topic_facet |
Age Distribution Aged 80 and over Exfoliation Syndrome Female Follow-Up Studies Humans Iceland Incidence Intraocular Pressure Male Middle Aged Prospective Studies Sex Distribution |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To examine the 5-year incidence of pseudoexfoliation (PEX) and monitor changes in related ophthalmologic variables. DESIGN: Population-based, prospective cohort study. METHODS: A random sample from the Reykjavik Population Census for persons 50 years and older was used. At baseline 1,045 participants were examined for signs of PEX including peripheral band and/or central shield of exfoliative material on the anterior lens capsule. Five years later, 846 (88.2%) of survivors returned for a follow-up visit. RESULTS: The 5-year incidence of PEX was 3.5% in right eyes only, and 5.2% in either eye. Age increased the risk of 5-year incidence by 5% when looking at 10-year age groups (P = .02); the incidence was higher in female subjects (P = .05) than in male. A total of 27% of clinically asymmetric cases converted to clinically bilateral disease over 5 years. Intraocular pressure increased in the group that developed PEX during the 5 years, but the size of the optic cup increased most in eyes that already had PEX at baseline. CONCLUSION: This incidence study from Iceland confirms findings from previous prevalence studies that PEX is increasingly common with older age in this population. Earliest changes related to PEX may be subtle and difficult to detect, which may lead to some misclassification. Further study is needed to identify clinical features that can reliably detect patients at risk for developing PEX. |
author2 |
Department of Ophthalmology, University of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Arnarsson, Arsaell Damji, Karim F Sasaki, Hiroshi Sverrisson, Thordur Jonasson, Fridbert |
author_facet |
Arnarsson, Arsaell Damji, Karim F Sasaki, Hiroshi Sverrisson, Thordur Jonasson, Fridbert |
author_sort |
Arnarsson, Arsaell |
title |
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
title_short |
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
title_full |
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
title_fullStr |
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
title_full_unstemmed |
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
title_sort |
pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. |
publisher |
Elsevier Science |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/81094 https://doi.org/10.1016/j.ajo.2009.03.021 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.ajo.2009.03.021 Am. J. Ophthalmol. 2009, 148(2):291-7 1879-1891 19427619 doi:10.1016/j.ajo.2009.03.021 http://hdl.handle.net/2336/81094 American journal of ophthalmology |
op_doi |
https://doi.org/10.1016/j.ajo.2009.03.021 |
container_title |
American Journal of Ophthalmology |
container_volume |
148 |
container_issue |
2 |
container_start_page |
291 |
op_container_end_page |
297 |
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1766038822381944832 |