Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. METHODS: We obtained a cohort of 47,697 children and adolescents ag...
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Oxford University Press
2009
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Online Access: | http://hdl.handle.net/2336/76328 https://doi.org/10.1093/jnci/djp104 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/76328 2023-05-15T16:50:01+02:00 Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. Olsen, Jørgen H Möller, Torgil Anderson, Harald Langmark, Frøydis Sankila, Risto Tryggvadottír, Laufey Winther, Jeanette Falck Rechnitzer, Catherine Jonmundsson, Gudmundur Christensen, Jane Garwicz, Stanislaw Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jorgen@cancer.dk 2009-08-05 http://hdl.handle.net/2336/76328 https://doi.org/10.1093/jnci/djp104 en eng Oxford University Press http://dx.doi.org/10.1093/jnci/djp104 J. Natl. Cancer Inst. 2009, 101(11):806-13 1460-2105 19470947 doi:10.1093/jnci/djp104 http://hdl.handle.net/2336/76328 Journal of the National Cancer Institute Adolescent Adult Age Factors Aged Brain Neoplasms Breast Neoplasms Child Preschool Cohort Studies Female Finland Follow-Up Studies Humans Iceland Incidence Infant Newborn Male Middle Aged Neoplasms Second Primary Poisson Distribution Registries Risk Assessment Risk Factors Scandinavia Survivors Time Factors Young Adult Article 2009 ftlandspitaliuni https://doi.org/10.1093/jnci/djp104 2022-05-29T08:21:23Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. METHODS: We obtained a cohort of 47,697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primary cancers notified to the registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs). We used a multiplicative Poisson regression model to estimate relative risk of cancer for attained age, with adjustment for calendar period and age at diagnosis of primary cancer. We also calculated excess absolute risk (EAR) attributable to status as childhood cancer survivor and determined the cumulative incidence of second primary cancer as a function of attained age for three subcohorts defined by period of treatment for childhood cancer. RESULTS: A total of 1180 asynchronous second primary cancers were observed in 1088 persons, yielding an overall SIR of 3.3 (95% confidence interval = 3.1 to 3.5). The relative risk was statistically significantly increased in all age groups, even for cohort members approaching 70 years of age. The EAR for second primary cancer among survivors increased gradually from one additional case per 1000 person-years of observation in early life to six additional cases per 1000 person-years in the age group 60-69 years. For children treated in the prechemotherapy era (1943-1959), the cumulative risk for a second primary cancer reached 18%, 34%, and 48% at ages 60, 70, and 80 years, respectively. The age-specific incidence rates were highest for cohort members treated in the era of intensive, multiple-agent chemotherapy (1975-2005). CONCLUSION: Survivors of childhood cancer have a ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway JNCI: Journal of the National Cancer Institute 101 11 806 813 |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Age Factors Aged Brain Neoplasms Breast Neoplasms Child Preschool Cohort Studies Female Finland Follow-Up Studies Humans Iceland Incidence Infant Newborn Male Middle Aged Neoplasms Second Primary Poisson Distribution Registries Risk Assessment Risk Factors Scandinavia Survivors Time Factors Young Adult |
spellingShingle |
Adolescent Adult Age Factors Aged Brain Neoplasms Breast Neoplasms Child Preschool Cohort Studies Female Finland Follow-Up Studies Humans Iceland Incidence Infant Newborn Male Middle Aged Neoplasms Second Primary Poisson Distribution Registries Risk Assessment Risk Factors Scandinavia Survivors Time Factors Young Adult Olsen, Jørgen H Möller, Torgil Anderson, Harald Langmark, Frøydis Sankila, Risto Tryggvadottír, Laufey Winther, Jeanette Falck Rechnitzer, Catherine Jonmundsson, Gudmundur Christensen, Jane Garwicz, Stanislaw Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
topic_facet |
Adolescent Adult Age Factors Aged Brain Neoplasms Breast Neoplasms Child Preschool Cohort Studies Female Finland Follow-Up Studies Humans Iceland Incidence Infant Newborn Male Middle Aged Neoplasms Second Primary Poisson Distribution Registries Risk Assessment Risk Factors Scandinavia Survivors Time Factors Young Adult |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. METHODS: We obtained a cohort of 47,697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primary cancers notified to the registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs). We used a multiplicative Poisson regression model to estimate relative risk of cancer for attained age, with adjustment for calendar period and age at diagnosis of primary cancer. We also calculated excess absolute risk (EAR) attributable to status as childhood cancer survivor and determined the cumulative incidence of second primary cancer as a function of attained age for three subcohorts defined by period of treatment for childhood cancer. RESULTS: A total of 1180 asynchronous second primary cancers were observed in 1088 persons, yielding an overall SIR of 3.3 (95% confidence interval = 3.1 to 3.5). The relative risk was statistically significantly increased in all age groups, even for cohort members approaching 70 years of age. The EAR for second primary cancer among survivors increased gradually from one additional case per 1000 person-years of observation in early life to six additional cases per 1000 person-years in the age group 60-69 years. For children treated in the prechemotherapy era (1943-1959), the cumulative risk for a second primary cancer reached 18%, 34%, and 48% at ages 60, 70, and 80 years, respectively. The age-specific incidence rates were highest for cohort members treated in the era of intensive, multiple-agent chemotherapy (1975-2005). CONCLUSION: Survivors of childhood cancer have a ... |
author2 |
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jorgen@cancer.dk |
format |
Article in Journal/Newspaper |
author |
Olsen, Jørgen H Möller, Torgil Anderson, Harald Langmark, Frøydis Sankila, Risto Tryggvadottír, Laufey Winther, Jeanette Falck Rechnitzer, Catherine Jonmundsson, Gudmundur Christensen, Jane Garwicz, Stanislaw |
author_facet |
Olsen, Jørgen H Möller, Torgil Anderson, Harald Langmark, Frøydis Sankila, Risto Tryggvadottír, Laufey Winther, Jeanette Falck Rechnitzer, Catherine Jonmundsson, Gudmundur Christensen, Jane Garwicz, Stanislaw |
author_sort |
Olsen, Jørgen H |
title |
Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
title_short |
Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
title_full |
Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
title_fullStr |
Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
title_full_unstemmed |
Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. |
title_sort |
lifelong cancer incidence in 47,697 patients treated for childhood cancer in the nordic countries. |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/76328 https://doi.org/10.1093/jnci/djp104 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1093/jnci/djp104 J. Natl. Cancer Inst. 2009, 101(11):806-13 1460-2105 19470947 doi:10.1093/jnci/djp104 http://hdl.handle.net/2336/76328 Journal of the National Cancer Institute |
op_doi |
https://doi.org/10.1093/jnci/djp104 |
container_title |
JNCI: Journal of the National Cancer Institute |
container_volume |
101 |
container_issue |
11 |
container_start_page |
806 |
op_container_end_page |
813 |
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1766040196527161344 |