Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND OBJECTIVES: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy numbe...
Published in: | International Immunology |
---|---|
Main Authors: | , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Oxford University Press
2009
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/76327 https://doi.org/10.1093/intimm/dxm117 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/76327 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/76327 2023-05-15T16:52:20+02:00 Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. Blasko, Bernadett Kolka, Ragnhildur Thorbjornsdottir, Perla Sigurdarson, Sigurdur Thor Sigurdsson, Gardar Rónai, Zsolt Sasvári-Székely, Mária Bödvarsson, Sigurdur Thorgeirsson, Gudmundur Prohászka, Zoltán Kovács, Margit Füst, George Arason, Gudmundur Johann Research Group of Inflammation Biology and Immunogenomics, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary. 2009-08-05 http://hdl.handle.net/2336/76327 https://doi.org/10.1093/intimm/dxm117 en eng Oxford University Press http://dx.doi.org/10.1093/intimm/dxm117 Int. Immunol. 2008, 20(1):31-7 1460-2377 18032375 doi:10.1093/intimm/dxm117 http://hdl.handle.net/2336/76327 International immunology Aged 80 and over Complement C4b Female Gene Dosage Genetic Predisposition to Disease Humans Iceland Lymphotoxin-alpha Male Myocardial Infarction Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Factors Smoking Survival Analysis Article 2009 ftlandspitaliuni https://doi.org/10.1093/intimm/dxm117 2022-05-29T08:21:23Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND OBJECTIVES: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement) is strongly associated with morbidity and mortality of cardiovascular diseases (CVD). The +252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the C4B gene was also reported to be related to CVD-related mortality in an Oriental population. METHODS: The relationship between the copy number of the genes encoding the fourth component of complement (C4A and C4B) and LTA 252 single-nucleotide polymorphism (SNP) on the one hand and mortality after acute myocardial infarction (AMI) was studied in 142 Icelandic patients. The number of the C4A and C4B genes was determined in genomic DNA samples by a newly developed real-time PCR-based method; lymphotoxin-alpha (LTA) +252 A>G polymorphism was determined by PCR-restriction fragment length polymorphism analysis. RESULTS: The C4B*Q0 genotype was found to be strongly associated with 1-year mortality, with a hazard ratio of 3.50 (1.38-8.87) (P = 0.008) (adjusted Cox regression analysis). This association was, however, restricted to ever-smoking patients. By contrast, neither C4A gene copy numbers nor LTA 252 SNP did confer increased risk of mortality after AMI. CONCLUSIONS: This observation indicates that low C4B copy number is a strong risk factor for short-term mortality after AMI in smoking Icelandic patients, whereas LTA 252 G allele is not a risk factor in Caucasian population. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive International Immunology 20 1 31 37 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Aged 80 and over Complement C4b Female Gene Dosage Genetic Predisposition to Disease Humans Iceland Lymphotoxin-alpha Male Myocardial Infarction Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Factors Smoking Survival Analysis |
spellingShingle |
Aged 80 and over Complement C4b Female Gene Dosage Genetic Predisposition to Disease Humans Iceland Lymphotoxin-alpha Male Myocardial Infarction Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Factors Smoking Survival Analysis Blasko, Bernadett Kolka, Ragnhildur Thorbjornsdottir, Perla Sigurdarson, Sigurdur Thor Sigurdsson, Gardar Rónai, Zsolt Sasvári-Székely, Mária Bödvarsson, Sigurdur Thorgeirsson, Gudmundur Prohászka, Zoltán Kovács, Margit Füst, George Arason, Gudmundur Johann Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
topic_facet |
Aged 80 and over Complement C4b Female Gene Dosage Genetic Predisposition to Disease Humans Iceland Lymphotoxin-alpha Male Myocardial Infarction Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Factors Smoking Survival Analysis |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND OBJECTIVES: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement) is strongly associated with morbidity and mortality of cardiovascular diseases (CVD). The +252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the C4B gene was also reported to be related to CVD-related mortality in an Oriental population. METHODS: The relationship between the copy number of the genes encoding the fourth component of complement (C4A and C4B) and LTA 252 single-nucleotide polymorphism (SNP) on the one hand and mortality after acute myocardial infarction (AMI) was studied in 142 Icelandic patients. The number of the C4A and C4B genes was determined in genomic DNA samples by a newly developed real-time PCR-based method; lymphotoxin-alpha (LTA) +252 A>G polymorphism was determined by PCR-restriction fragment length polymorphism analysis. RESULTS: The C4B*Q0 genotype was found to be strongly associated with 1-year mortality, with a hazard ratio of 3.50 (1.38-8.87) (P = 0.008) (adjusted Cox regression analysis). This association was, however, restricted to ever-smoking patients. By contrast, neither C4A gene copy numbers nor LTA 252 SNP did confer increased risk of mortality after AMI. CONCLUSIONS: This observation indicates that low C4B copy number is a strong risk factor for short-term mortality after AMI in smoking Icelandic patients, whereas LTA 252 G allele is not a risk factor in Caucasian population. |
author2 |
Research Group of Inflammation Biology and Immunogenomics, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary. |
format |
Article in Journal/Newspaper |
author |
Blasko, Bernadett Kolka, Ragnhildur Thorbjornsdottir, Perla Sigurdarson, Sigurdur Thor Sigurdsson, Gardar Rónai, Zsolt Sasvári-Székely, Mária Bödvarsson, Sigurdur Thorgeirsson, Gudmundur Prohászka, Zoltán Kovács, Margit Füst, George Arason, Gudmundur Johann |
author_facet |
Blasko, Bernadett Kolka, Ragnhildur Thorbjornsdottir, Perla Sigurdarson, Sigurdur Thor Sigurdsson, Gardar Rónai, Zsolt Sasvári-Székely, Mária Bödvarsson, Sigurdur Thorgeirsson, Gudmundur Prohászka, Zoltán Kovács, Margit Füst, George Arason, Gudmundur Johann |
author_sort |
Blasko, Bernadett |
title |
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
title_short |
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
title_full |
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
title_fullStr |
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
title_full_unstemmed |
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. |
title_sort |
low complement c4b gene copy number predicts short-term mortality after acute myocardial infarction. |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/76327 https://doi.org/10.1093/intimm/dxm117 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1093/intimm/dxm117 Int. Immunol. 2008, 20(1):31-7 1460-2377 18032375 doi:10.1093/intimm/dxm117 http://hdl.handle.net/2336/76327 International immunology |
op_doi |
https://doi.org/10.1093/intimm/dxm117 |
container_title |
International Immunology |
container_volume |
20 |
container_issue |
1 |
container_start_page |
31 |
op_container_end_page |
37 |
_version_ |
1766042482121900032 |