Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Current guidelines for interstitial lung disease support a surgical biopsy for optimal diagnosis and treatment, yet only a minority of patients undergo such biopsy. Our objectiv...
Published in: | The Annals of Thoracic Surgery |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/73274 2023-05-15T16:51:28+02:00 Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study Sigurdsson, Martin I Isaksson, Helgi J Gudmundsson, Gunnar Gudbjartsson, Tomas Department of Cardiothoracic Surgery, Landspitali University Hospital Reykjavik, Reykjavik, Iceland. 2009-07-10 http://hdl.handle.net/2336/73274 https://doi.org/10.1016/j.athoracsur.2009.04.002 en eng Elsevier http://dx.doi.org/10.1016/j.athoracsur.2009.04.002 Ann. Thorac. Surg. 2009, 88(1):227-32 1552-6259 19559230 doi:10.1016/j.athoracsur.2009.04.002 http://hdl.handle.net/2336/73274 Annals of thoracic surgery PubMed - in process Article 2009 ftlandspitaliuni https://doi.org/10.1016/j.athoracsur.2009.04.002 2022-05-29T08:21:21Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Current guidelines for interstitial lung disease support a surgical biopsy for optimal diagnosis and treatment, yet only a minority of patients undergo such biopsy. Our objectives were to address the properties of a surgical lung biopsy for suspected interstitial lung disease, the diagnostic yield of the procedure, and whether it resulted in changes in diagnosis and treatment. METHODS: A retrospective nationwide study including 73 patients (mean age, 57.3 years; 58% males) who underwent a surgical lung biopsy for suspected interstitial disease in Iceland between 1986 and 2007 was conducted. Patient records and histologic specimens were reviewed. Before the surgical biopsy a transbronchial or computed tomography-guided biopsy had been performed in two thirds of the patients. RESULTS: The complication rate for surgical lung biopsy was 16%, and 30-day operative mortality was 2.7%, both significantly higher in patients with preoperative respiratory failure. After the procedure, a definite histopathologic diagnosis was obtained in 81% of the patients. Usual interstitial pneumonia was the most common diagnosis (31%). The clinical diagnosis was changed for 73% of the patients, and in 53% of the patients the biopsy resulted in changes in treatment. CONCLUSIONS: Surgical lung biopsy is a powerful tool for diagnosis of suspected interstitial lung disease. It results in a specific diagnosis for the majority of patients and changes in treatment for more than half. Operative morbidity and mortality are low but still significant, so patients should be carefully selected for the procedure, especially those with respiratory failure. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive The Annals of Thoracic Surgery 88 1 227 232 |
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Hirsla - Landspítali University Hospital research archive |
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PubMed - in process Sigurdsson, Martin I Isaksson, Helgi J Gudmundsson, Gunnar Gudbjartsson, Tomas Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
topic_facet |
PubMed - in process |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Current guidelines for interstitial lung disease support a surgical biopsy for optimal diagnosis and treatment, yet only a minority of patients undergo such biopsy. Our objectives were to address the properties of a surgical lung biopsy for suspected interstitial lung disease, the diagnostic yield of the procedure, and whether it resulted in changes in diagnosis and treatment. METHODS: A retrospective nationwide study including 73 patients (mean age, 57.3 years; 58% males) who underwent a surgical lung biopsy for suspected interstitial disease in Iceland between 1986 and 2007 was conducted. Patient records and histologic specimens were reviewed. Before the surgical biopsy a transbronchial or computed tomography-guided biopsy had been performed in two thirds of the patients. RESULTS: The complication rate for surgical lung biopsy was 16%, and 30-day operative mortality was 2.7%, both significantly higher in patients with preoperative respiratory failure. After the procedure, a definite histopathologic diagnosis was obtained in 81% of the patients. Usual interstitial pneumonia was the most common diagnosis (31%). The clinical diagnosis was changed for 73% of the patients, and in 53% of the patients the biopsy resulted in changes in treatment. CONCLUSIONS: Surgical lung biopsy is a powerful tool for diagnosis of suspected interstitial lung disease. It results in a specific diagnosis for the majority of patients and changes in treatment for more than half. Operative morbidity and mortality are low but still significant, so patients should be carefully selected for the procedure, especially those with respiratory failure. |
author2 |
Department of Cardiothoracic Surgery, Landspitali University Hospital Reykjavik, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Sigurdsson, Martin I Isaksson, Helgi J Gudmundsson, Gunnar Gudbjartsson, Tomas |
author_facet |
Sigurdsson, Martin I Isaksson, Helgi J Gudmundsson, Gunnar Gudbjartsson, Tomas |
author_sort |
Sigurdsson, Martin I |
title |
Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
title_short |
Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
title_full |
Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
title_fullStr |
Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
title_full_unstemmed |
Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
title_sort |
diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study |
publisher |
Elsevier |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/73274 https://doi.org/10.1016/j.athoracsur.2009.04.002 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1016/j.athoracsur.2009.04.002 Ann. Thorac. Surg. 2009, 88(1):227-32 1552-6259 19559230 doi:10.1016/j.athoracsur.2009.04.002 http://hdl.handle.net/2336/73274 Annals of thoracic surgery |
op_doi |
https://doi.org/10.1016/j.athoracsur.2009.04.002 |
container_title |
The Annals of Thoracic Surgery |
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88 |
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1 |
container_start_page |
227 |
op_container_end_page |
232 |
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1766041576150138880 |