No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field There have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal re...
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/67874 2023-05-15T16:48:44+02:00 No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 Kalsi, G Gamble, D Curtis, D Brynjolfsson, J Sigmundsson, T Butler, R Read, T Murphy, P Petursson, H Gurling, H M Windeyer Institute of Medical Research, Department of Psychiatry and Behavioural Sciences, UCL Medical School, London, UK. 2009-05-12 http://hdl.handle.net/2336/67874 en eng Lippincott Williams & Wilkins http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-199912000-00006&D=ovftd Psychiatr. Genet. 1999, 9(4):197-9 0955-8829 10697827 http://hdl.handle.net/2336/67874 Psychiatric genetics Chromosome Mapping Chromosomes Human Pair 11 Female Genetic Markers Great Britain Humans Iceland Linkage (Genetics) Lod Score Male Pedigree Schizophrenia Statistics Nonparametric Article 2009 ftlandspitaliuni 2022-05-29T08:21:20Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field There have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal region, but when evidence that weakened this hypothesis accumulated, he proposed that a susceptibility locus might be present elsewhere on the sex chromosomes instead. DeLisi et al. (1994) found a small nonsignificant positive lod score between the marker DXS7 and schizophrenia, but other failed to replicate this finding. Another study reported by Crow and DeLisi's group was also weakly positive for this marker (Dann et al., 1997). This locus was then investigated in a collaborative study by Laval et al. (1997), which produced a nonparametric lod score of 2.44. Using a sample of 17 pedigrees from Britain and Iceland, we have also tested the hypothesis of linkage between DXS7 and schizophrenia. The 17 families were selected from a larger sample on the basis of an absence of male-to-male transmission for schizophrenia. These families were originally selected for having multiple cases of schizophrenia within them and for having no cases of bipolar affective disorder. We genotyped subjects for a marker at DXS7 and performed classical lod score and model-free linkage analysis using broad and narrow definitions of affection with schizophrenia. We found strongly negative lod scores and no evidence for linkage using model-free analysis. Therefore, this study does not support the hypothesis of linkage of schizophrenia to DXS7, and the evidence for a susceptibility locus on this part of the X chromosome is weakened. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive |
institution |
Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Chromosome Mapping Chromosomes Human Pair 11 Female Genetic Markers Great Britain Humans Iceland Linkage (Genetics) Lod Score Male Pedigree Schizophrenia Statistics Nonparametric |
spellingShingle |
Chromosome Mapping Chromosomes Human Pair 11 Female Genetic Markers Great Britain Humans Iceland Linkage (Genetics) Lod Score Male Pedigree Schizophrenia Statistics Nonparametric Kalsi, G Gamble, D Curtis, D Brynjolfsson, J Sigmundsson, T Butler, R Read, T Murphy, P Petursson, H Gurling, H M No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
topic_facet |
Chromosome Mapping Chromosomes Human Pair 11 Female Genetic Markers Great Britain Humans Iceland Linkage (Genetics) Lod Score Male Pedigree Schizophrenia Statistics Nonparametric |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field There have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal region, but when evidence that weakened this hypothesis accumulated, he proposed that a susceptibility locus might be present elsewhere on the sex chromosomes instead. DeLisi et al. (1994) found a small nonsignificant positive lod score between the marker DXS7 and schizophrenia, but other failed to replicate this finding. Another study reported by Crow and DeLisi's group was also weakly positive for this marker (Dann et al., 1997). This locus was then investigated in a collaborative study by Laval et al. (1997), which produced a nonparametric lod score of 2.44. Using a sample of 17 pedigrees from Britain and Iceland, we have also tested the hypothesis of linkage between DXS7 and schizophrenia. The 17 families were selected from a larger sample on the basis of an absence of male-to-male transmission for schizophrenia. These families were originally selected for having multiple cases of schizophrenia within them and for having no cases of bipolar affective disorder. We genotyped subjects for a marker at DXS7 and performed classical lod score and model-free linkage analysis using broad and narrow definitions of affection with schizophrenia. We found strongly negative lod scores and no evidence for linkage using model-free analysis. Therefore, this study does not support the hypothesis of linkage of schizophrenia to DXS7, and the evidence for a susceptibility locus on this part of the X chromosome is weakened. |
author2 |
Windeyer Institute of Medical Research, Department of Psychiatry and Behavioural Sciences, UCL Medical School, London, UK. |
format |
Article in Journal/Newspaper |
author |
Kalsi, G Gamble, D Curtis, D Brynjolfsson, J Sigmundsson, T Butler, R Read, T Murphy, P Petursson, H Gurling, H M |
author_facet |
Kalsi, G Gamble, D Curtis, D Brynjolfsson, J Sigmundsson, T Butler, R Read, T Murphy, P Petursson, H Gurling, H M |
author_sort |
Kalsi, G |
title |
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
title_short |
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
title_full |
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
title_fullStr |
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
title_full_unstemmed |
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 |
title_sort |
no evidence for linkage of schizophrenia to dxs7 at chromosome xp11 |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/67874 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-199912000-00006&D=ovftd Psychiatr. Genet. 1999, 9(4):197-9 0955-8829 10697827 http://hdl.handle.net/2336/67874 Psychiatric genetics |
_version_ |
1766038821428789248 |