Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,6...
Published in: | American Journal of Epidemiology |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/66993 2023-05-15T16:50:57+02:00 Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study Andresdottir, Margret B Sigfusson, Nikulas Sigvaldason, Helgi Gudnason, Vilmundur Icelandic Heart Association-Research Institute, Kópavogur, Iceland. margret@hjarta.is 2009-05-04 http://hdl.handle.net/2336/66993 https://doi.org/10.1093/aje/kwg222 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/abstract/158/9/844 Am. J. Epidemiol. 2003, 158(9):844-51 0002-9262 14585762 doi:10.1093/aje/kwg222 http://hdl.handle.net/2336/66993 American journal of epidemiology Aged Article 2009 ftlandspitaliuni https://doi.org/10.1093/aje/kwg222 2022-05-29T08:21:20Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,685 women who participated in The Reykjavik Study (Iceland). Cardiovascular risk assessment was based on characteristics at baseline, from 1967 to 1996. During an average follow-up of 19 and 20 years, 2,092 men and 801 women, respectively, developed CHD, and 251 men and 178 women died from cerebrovascular accident. For men, the fully adjusted increase in risk of developing CHD predicted by the top compared with the bottom quintile of ESR was 57% (hazard ratio = 1.57, 95% confidence interval: 1.38, 1.78; p < 0.001); for women, risk was increased by 49% (hazard ratio = 1.49, 95% confidence interval: 1.16, 1.90; p < 0.001). The increased risk after baseline ESR measurement was stable for up to 25 years for men and 20 years for women. The fully adjusted risk of death due to stroke predicted by increasing the ln(ESR + 1) by one standard deviation was increased by 15% for men (p = 0.06) and 16% for women (p = 0.08). In conclusion, ESR is a long-term independent predictor of CHD in both men and women. These findings support the evidence of an inflammatory process in atherosclerosis. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Epidemiology 158 9 844 851 |
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Aged Andresdottir, Margret B Sigfusson, Nikulas Sigvaldason, Helgi Gudnason, Vilmundur Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
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To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,685 women who participated in The Reykjavik Study (Iceland). Cardiovascular risk assessment was based on characteristics at baseline, from 1967 to 1996. During an average follow-up of 19 and 20 years, 2,092 men and 801 women, respectively, developed CHD, and 251 men and 178 women died from cerebrovascular accident. For men, the fully adjusted increase in risk of developing CHD predicted by the top compared with the bottom quintile of ESR was 57% (hazard ratio = 1.57, 95% confidence interval: 1.38, 1.78; p < 0.001); for women, risk was increased by 49% (hazard ratio = 1.49, 95% confidence interval: 1.16, 1.90; p < 0.001). The increased risk after baseline ESR measurement was stable for up to 25 years for men and 20 years for women. The fully adjusted risk of death due to stroke predicted by increasing the ln(ESR + 1) by one standard deviation was increased by 15% for men (p = 0.06) and 16% for women (p = 0.08). In conclusion, ESR is a long-term independent predictor of CHD in both men and women. These findings support the evidence of an inflammatory process in atherosclerosis. |
author2 |
Icelandic Heart Association-Research Institute, Kópavogur, Iceland. margret@hjarta.is |
format |
Article in Journal/Newspaper |
author |
Andresdottir, Margret B Sigfusson, Nikulas Sigvaldason, Helgi Gudnason, Vilmundur |
author_facet |
Andresdottir, Margret B Sigfusson, Nikulas Sigvaldason, Helgi Gudnason, Vilmundur |
author_sort |
Andresdottir, Margret B |
title |
Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
title_short |
Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
title_full |
Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
title_fullStr |
Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
title_full_unstemmed |
Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study |
title_sort |
erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: the reykjavik study |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/66993 https://doi.org/10.1093/aje/kwg222 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://aje.oxfordjournals.org/cgi/content/abstract/158/9/844 Am. J. Epidemiol. 2003, 158(9):844-51 0002-9262 14585762 doi:10.1093/aje/kwg222 http://hdl.handle.net/2336/66993 American journal of epidemiology |
op_doi |
https://doi.org/10.1093/aje/kwg222 |
container_title |
American Journal of Epidemiology |
container_volume |
158 |
container_issue |
9 |
container_start_page |
844 |
op_container_end_page |
851 |
_version_ |
1766041066388062208 |