Algengi IgG mótefna gegn Toxoplasma gondii, Helicobacter pylori og lifrarbólguveiru A á Íslandi. Tengsl við ofnæmi og lungnaeinkenni

• Main Authors: Hulda Ásbjörnsdóttir, Rúna B Sigurjónsdóttir, Signý V Sveinsdóttir, Alda Birgisdóttir, Davíð Gíslason, Christer Jansson, Ísleifur Ólafsson, Þórarinn Gíslason, Bjarni Þjóðleifsson
• Format: Article in Journal/Newspaper
• Language: Icelandic
• Published: Læknafélag Íslands, Læknafélag Reykjavíkur 2006
• Subjects: Faraldsfræði; Smitsjúkdómar; Lungnasjúkdómar; Ofnæmi; Veirur; Fræðigreinar; LBL12; Adult; Animals; Antibodies; Bacterial; Protozoan; Asthma; English Abstract; Enzyme-Linked Immunosorbent Assay; Female; Food Poisoning; Forced Expiratory Volume; Helicobacter Infections; Helicobacter pylori; Hepatitis A; Hepatitis A virus; Humans; Hypersensitivity; Immediate; Iceland/epidemiology; Immunoglobulin G; Logistic Models; Lung; Male; Middle Aged; Odds Ratio; Prevalence; Questionnaires; Toxoplasma; Smella; Iceland
• Online Access: http://hdl.handle.net/2336/6604

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open BACKGROUND: Foodborne or orofecal transmitted infections can have influence on health by direct consequences of the infection and indirectly by modulating the immune system. OBJECTIVES: To investigate the prevalence and risk factors for T. gondii, H. pylori and HAV infection in the Icelandic population and their influence on atopy, allergy related lung symptoms and lung function. MATERIAL AND METHODS: Blood samples were collected in 1999-2001 from 505 subjects in age group 28-52, randomly selected from the Icelandic population. The presence of T. gondii, H. pylori and HAV IgG antibodies was determined by an ELISA method. Allergy related lung symptoms were assessed with questionnaire and IgE sensitization and lung function measured. X(2) test was used to test for trend but unadjusted logistic regression for comparison of IgG prevalence. Multiple logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals for different infections factors. RESULTS: The prevalence of antibodies was 9.8%, for T. gondii, 36.3% for H. pylori and 4.9% for HAV. Attending day care before the age of 3 years was a risk factor for having T. gondii antibodies. The prevalence of H. pylori increased with age and smoking. The infections were not associated with the prevalence of asthma or atopy. Having IgG antibodies against T. gondii was, however, associated with an increased risk of having FEV/FVC ratio below 70%. CONCLUSION: T. gondii, H. pylori and H AV infection does not influence the prevalence of atopy or asthma. The data indicated that infection with T. gondii might be associated with a diminished lung function.