Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever...
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British Medical Assn
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Online Access: | http://hdl.handle.net/2336/6583 https://doi.org/10.1136/thx.2005.040881 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/6583 2023-05-15T16:52:47+02:00 Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey Gómez Real, F Svanes, C Bjornsson, E H Franklin, K A Franklin, K Gislason, D Gislason, T Gulsvik, A Janson, C Jögi, R Kiserud, T Norbäck, D Nyström, L Torén, K Wentzel-Larsen, T Omenaas, E 2006-12-15 YES http://hdl.handle.net/2336/6583 https://doi.org/10.1136/thx.2005.040881 en eng British Medical Assn http://thorax.bmj.com/cgi/content/full/61/1/34 Thorax 2006, 61(1):34-40 0040-6376 16244093 doi:10.1136/thx.2005.040881 PAD12 http://hdl.handle.net/2336/6583 Thorax Adult Asthma Body Mass Index Cross-Sectional Studies Female Hormone Replacement Therapy Middle Aged Perimenopause Questionnaires Rhinitis Allergic Seasonal Smoking Article 2006 ftlandspitaliuni https://doi.org/10.1136/thx.2005.040881 2022-05-29T08:20:55Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever in a population of perimenopausal women, focusing on a possible interaction with body mass index (BMI). METHODS: A postal questionnaire was sent to population based samples in Denmark, Estonia, Iceland, Norway, and Sweden in 1999-2001, and 8588 women aged 25-54 years responded (77%). Pregnant women, women using oral contraceptives, and women <46 years were excluded. Analyses included 2206 women aged 46-54 years of which 884 were menopausal and 540 used HRT. Stratified analyses by BMI in tertiles were performed. RESULTS: HRT was associated with an increased risk for asthma (OR 1.57 (95% CI 1.07 to 2.30)), wheeze (OR 1.60 (95% CI 1.22 to 2.10)), and hay fever (OR 1.48 (95% CI 1.15 to 1.90)). The associations with asthma and wheeze were significantly stronger among women with BMI in the lower tertile (asthma OR 2.41 (95% CI 1.21 to 4.77); wheeze OR 2.04 (95% CI 1.23 to 3.36)) than in heavier women (asthma: p(interaction) = 0.030; wheeze: p(interaction) = 0.042). Increasing BMI was associated with more asthma (OR 1.08 (95% CI 1.05 to 1.12) per kg/m2). This effect was only found in women not taking HRT (OR 1.10 (95% CI 1.05 to 1.14) per kg/m2); no such association was detected in HRT users (OR 1.00 (95% CI 0.92 to 1.08) per kg/m2) (p(interaction) = 0.046). Menopause was not significantly associated with asthma, wheeze, or hay fever. CONCLUSIONS: In perimenopausal women there is an interaction between HRT and BMI in the effects on asthma. Lean women who were HRT users had as high a risk for asthma as overweight women not taking HRT. It is suggested that HRT and overweight increase the risk of asthma through partly common pathways. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Norway Thorax 61 1 34 40 |
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Open Polar |
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Hirsla - Landspítali University Hospital research archive |
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ftlandspitaliuni |
language |
English |
topic |
Adult Asthma Body Mass Index Cross-Sectional Studies Female Hormone Replacement Therapy Middle Aged Perimenopause Questionnaires Rhinitis Allergic Seasonal Smoking |
spellingShingle |
Adult Asthma Body Mass Index Cross-Sectional Studies Female Hormone Replacement Therapy Middle Aged Perimenopause Questionnaires Rhinitis Allergic Seasonal Smoking Gómez Real, F Svanes, C Bjornsson, E H Franklin, K A Franklin, K Gislason, D Gislason, T Gulsvik, A Janson, C Jögi, R Kiserud, T Norbäck, D Nyström, L Torén, K Wentzel-Larsen, T Omenaas, E Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
topic_facet |
Adult Asthma Body Mass Index Cross-Sectional Studies Female Hormone Replacement Therapy Middle Aged Perimenopause Questionnaires Rhinitis Allergic Seasonal Smoking |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever in a population of perimenopausal women, focusing on a possible interaction with body mass index (BMI). METHODS: A postal questionnaire was sent to population based samples in Denmark, Estonia, Iceland, Norway, and Sweden in 1999-2001, and 8588 women aged 25-54 years responded (77%). Pregnant women, women using oral contraceptives, and women <46 years were excluded. Analyses included 2206 women aged 46-54 years of which 884 were menopausal and 540 used HRT. Stratified analyses by BMI in tertiles were performed. RESULTS: HRT was associated with an increased risk for asthma (OR 1.57 (95% CI 1.07 to 2.30)), wheeze (OR 1.60 (95% CI 1.22 to 2.10)), and hay fever (OR 1.48 (95% CI 1.15 to 1.90)). The associations with asthma and wheeze were significantly stronger among women with BMI in the lower tertile (asthma OR 2.41 (95% CI 1.21 to 4.77); wheeze OR 2.04 (95% CI 1.23 to 3.36)) than in heavier women (asthma: p(interaction) = 0.030; wheeze: p(interaction) = 0.042). Increasing BMI was associated with more asthma (OR 1.08 (95% CI 1.05 to 1.12) per kg/m2). This effect was only found in women not taking HRT (OR 1.10 (95% CI 1.05 to 1.14) per kg/m2); no such association was detected in HRT users (OR 1.00 (95% CI 0.92 to 1.08) per kg/m2) (p(interaction) = 0.046). Menopause was not significantly associated with asthma, wheeze, or hay fever. CONCLUSIONS: In perimenopausal women there is an interaction between HRT and BMI in the effects on asthma. Lean women who were HRT users had as high a risk for asthma as overweight women not taking HRT. It is suggested that HRT and overweight increase the risk of asthma through partly common pathways. |
format |
Article in Journal/Newspaper |
author |
Gómez Real, F Svanes, C Bjornsson, E H Franklin, K A Franklin, K Gislason, D Gislason, T Gulsvik, A Janson, C Jögi, R Kiserud, T Norbäck, D Nyström, L Torén, K Wentzel-Larsen, T Omenaas, E |
author_facet |
Gómez Real, F Svanes, C Bjornsson, E H Franklin, K A Franklin, K Gislason, D Gislason, T Gulsvik, A Janson, C Jögi, R Kiserud, T Norbäck, D Nyström, L Torén, K Wentzel-Larsen, T Omenaas, E |
author_sort |
Gómez Real, F |
title |
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
title_short |
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
title_full |
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
title_fullStr |
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
title_full_unstemmed |
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
title_sort |
hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey |
publisher |
British Medical Assn |
publishDate |
2006 |
url |
http://hdl.handle.net/2336/6583 https://doi.org/10.1136/thx.2005.040881 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://thorax.bmj.com/cgi/content/full/61/1/34 Thorax 2006, 61(1):34-40 0040-6376 16244093 doi:10.1136/thx.2005.040881 PAD12 http://hdl.handle.net/2336/6583 Thorax |
op_doi |
https://doi.org/10.1136/thx.2005.040881 |
container_title |
Thorax |
container_volume |
61 |
container_issue |
1 |
container_start_page |
34 |
op_container_end_page |
40 |
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1766043162580615168 |