Algengi mótefna gegn Helicobacter pylori á Íslandi

• Main Authors: Karl G. Kristinsson, Erla Sigvaldadóttir, Bjarni Þjóðleifsson
• Format: Article in Journal/Newspaper
• Language: Icelandic
• Published: Læknafélag Íslands, Læknafélag Reykjavíkur 2009
• Subjects: Magakrabbamein; Helicobacter Infections; Prevalence; Helicobacter pylori; Antibodies; Bacterial; Iceland; Gastritis; Serology; Smella
• Online Access: http://hdl.handle.net/2336/65284

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Helicobacter pylori causes gastritis and duodenal ulcerations, and is possibly one of the causes of gastric cancer. Diagnosis has relied on gastroscopy, but with the advent of reliable serological tests, epidemiological studies have become easier. Previous studies have indicated a higher H. pylori infection rate in Iceland than neighbouring countries. To study this further, an H. pylori (acid glycine extract) ELISA test was set up. Serum samples were obtained from 387 individuals, aged three months to 97 years, mean 41 years (161 blood donors, 83 outpatients, 64 ante natal clinic, 33 hospitalised children, 27 old people's home and 19 college students). Positive antibody titers were found in 151 (39%), of which 14 were borderline. The prevalence increased with age and was highest 75% in 60-69 years old, but lowest 9% in the youngest age group. The prevalence of H. pylori antibodies appears to be higher than in neighbouring countries, but lower than in the developing countries, and Icelanders appear to acquire the infection at a younger age than in the neighbouring countries. This high prevalence is important in view of the high prevalence of gastric cancer in Iceland. Helicobacter pylori veldur magabólgu og skeifugarnarsárum, og er mögulega ein af orsökum magakrabbameins. Greining sýkingar hefur venjulega byggst á magaspeglun, en tilkoma nýrra prófa til mótefnamælinga hefur gert faraldsfræðirannsóknir einfaldari. Fyrri rannsóknir hafa bent til hærri tíðni sjúkdómsins á Íslandi en í nágrannalöndunum. Til að afla nánari upplýsinga um algengi og faraldsfræði sjúkdómsins hér á landi var sett upp mótefnapróf, þar sem mótefni í blóði voru mæld með ELISA aðferð. Blóðsýni voru tekin frá 387 einstaklingum á aldrinum þriggja mánaða til 97 ára, meðalaldur 41 ár (161 blóðgjafi, 83 sjúklingar á göngudeild, 64 konur í mæðraeftirliti, 33 börn á Landspítalanum, 27 vistmenn á dvalarheimili aldraðra og 19 menntaskólanemar). Mótefni ...