A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cas...
Published in: | European Journal of Cancer |
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Elsevier Science Ltd.
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Online Access: | http://hdl.handle.net/2336/6467 https://doi.org/10.1016/j.ejca.2005.11.029 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/6467 2023-05-15T16:44:49+02:00 A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland Eldon, Bjarki Jonsson Thorlacius, Steinunn Jonsson, Thorvaldur Jonasson, Jon Gunnlaugur Kjartansson, Jens Bodvarsson, Sigurdur Steingrimsson, Eirikur Rafnar, Thorunn 2006-12-08 YES http://hdl.handle.net/2336/6467 https://doi.org/10.1016/j.ejca.2005.11.029 en eng Elsevier Science Ltd. http://www.sciencedirect.com/science/article/B6T68-4JFHDYS-5/2/582e2b6c2a65fb6a6901006cb3d2536c Eur. J. Cancer 2006, 42(7):922-6 0959-8049 16530404 doi:10.1016/j.ejca.2005.11.029 DAV12 http://hdl.handle.net/2336/6467 European journal of cancer (Oxford, England : 1990) Adult Female Genetic Predisposition to Disease Humans Iceland/epidemiology Male Melanoma Middle Aged Pedigree Risk Assessment Risk Factors Skin Neoplasms Article 2006 ftlandspitaliuni https://doi.org/10.1016/j.ejca.2005.11.029 2022-05-29T08:20:55Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cases diagnosed in Iceland over a 45-year period (1955-1999), using data from the National Cancer Registry and a genealogy database that covers the whole of Iceland's population. First-, second-, and third-degree relatives of CMM patients did not have an increased risk of the disease, and no added risk of other types of cancer among relatives was observed, except for thyroid cancer in first-degree male relatives. Seven individuals were diagnosed with two or more primary CMM in this period; none of these individuals had a first or second-degree relative with CMM. Altogether, 2.4% of cases were familial, as defined by commonly used criteria. In conclusion, high-penetrance susceptibility genes do not contribute much to CMM in the Icelandic population. The great majority of CMM cases in Iceland are most likely caused by the interplay between environmental causes and low-risk genes. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive European Journal of Cancer 42 7 922 926 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Female Genetic Predisposition to Disease Humans Iceland/epidemiology Male Melanoma Middle Aged Pedigree Risk Assessment Risk Factors Skin Neoplasms |
spellingShingle |
Adult Female Genetic Predisposition to Disease Humans Iceland/epidemiology Male Melanoma Middle Aged Pedigree Risk Assessment Risk Factors Skin Neoplasms Eldon, Bjarki Jonsson Thorlacius, Steinunn Jonsson, Thorvaldur Jonasson, Jon Gunnlaugur Kjartansson, Jens Bodvarsson, Sigurdur Steingrimsson, Eirikur Rafnar, Thorunn A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
topic_facet |
Adult Female Genetic Predisposition to Disease Humans Iceland/epidemiology Male Melanoma Middle Aged Pedigree Risk Assessment Risk Factors Skin Neoplasms |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cases diagnosed in Iceland over a 45-year period (1955-1999), using data from the National Cancer Registry and a genealogy database that covers the whole of Iceland's population. First-, second-, and third-degree relatives of CMM patients did not have an increased risk of the disease, and no added risk of other types of cancer among relatives was observed, except for thyroid cancer in first-degree male relatives. Seven individuals were diagnosed with two or more primary CMM in this period; none of these individuals had a first or second-degree relative with CMM. Altogether, 2.4% of cases were familial, as defined by commonly used criteria. In conclusion, high-penetrance susceptibility genes do not contribute much to CMM in the Icelandic population. The great majority of CMM cases in Iceland are most likely caused by the interplay between environmental causes and low-risk genes. |
format |
Article in Journal/Newspaper |
author |
Eldon, Bjarki Jonsson Thorlacius, Steinunn Jonsson, Thorvaldur Jonasson, Jon Gunnlaugur Kjartansson, Jens Bodvarsson, Sigurdur Steingrimsson, Eirikur Rafnar, Thorunn |
author_facet |
Eldon, Bjarki Jonsson Thorlacius, Steinunn Jonsson, Thorvaldur Jonasson, Jon Gunnlaugur Kjartansson, Jens Bodvarsson, Sigurdur Steingrimsson, Eirikur Rafnar, Thorunn |
author_sort |
Eldon, Bjarki Jonsson |
title |
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
title_short |
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
title_full |
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
title_fullStr |
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
title_full_unstemmed |
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland |
title_sort |
population-based study on the familial aggregation of cutaneous malignant melanoma in iceland |
publisher |
Elsevier Science Ltd. |
publishDate |
2006 |
url |
http://hdl.handle.net/2336/6467 https://doi.org/10.1016/j.ejca.2005.11.029 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.sciencedirect.com/science/article/B6T68-4JFHDYS-5/2/582e2b6c2a65fb6a6901006cb3d2536c Eur. J. Cancer 2006, 42(7):922-6 0959-8049 16530404 doi:10.1016/j.ejca.2005.11.029 DAV12 http://hdl.handle.net/2336/6467 European journal of cancer (Oxford, England : 1990) |
op_doi |
https://doi.org/10.1016/j.ejca.2005.11.029 |
container_title |
European Journal of Cancer |
container_volume |
42 |
container_issue |
7 |
container_start_page |
922 |
op_container_end_page |
926 |
_version_ |
1766035073887371264 |