A common variant associated with prostate cancer in European and African populations
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a regio...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/6357 https://doi.org/10.1038/ng1808 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/6357 2023-05-15T16:50:25+02:00 A common variant associated with prostate cancer in European and African populations Amundadottir, Laufey T Sulem, Patrick Gudmundsson, Julius Helgason, Agnar Baker, Adam Agnarsson, Bjarni A Sigurdsson, Asgeir Benediktsdottir, Kristrun R Cazier, Jean-Baptiste Sainz, Jesus Jakobsdottir, Margret Kostic, Jelena Magnusdottir, Droplaug N Ghosh, Shyamali Agnarsson, Kari Birgisdottir, Birgitta Le Roux, Louise Olafsdottir, Adalheidur Blondal, Thorarinn Andresdottir, Margret Gretarsdottir, Olafia Svandis Bergthorsson, Jon T Gudbjartsson, Daniel Gylfason, Arnaldur Thorleifsson, Gudmar Manolescu, Andrei Kristjansson, Kristleifur Geirsson, Gudmundur Isaksson, Helgi Douglas, Julie Johansson, Jan-Erik Bälter, Katarina Wiklund, Fredrik Montie, James E Yu, Xiaoying Suarez, Brian K Ober, Carole Cooney, Kathleen A Gronberg, Henrik Catalona, William J Einarsson, Gudmundur V Barkardottir, Rosa B Gulcher, Jeffrey R Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari 2006-12-05 YES http://hdl.handle.net/2336/6357 https://doi.org/10.1038/ng1808 en eng Nature Pub. Co. http://www.nature.com/ng/journal/v38/n6/full/ng1808.html Nat. Genet. 2006, 38(6):652-8 1061-4036 16682969 doi:10.1038/ng1808 PTT12 URO12 http://hdl.handle.net/2336/6357 African Continental Ancestry Group Alleles European Continental Ancestry Group Male Microsatellite Repeats Polymorphism Single Nucleotide Prostatic Neoplasms Research Support N.I.H. Extramural Non-U.S. Gov't Article 2006 ftlandspitaliuni https://doi.org/10.1038/ng1808 2022-05-29T08:20:55Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 38 6 652 658 |
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African Continental Ancestry Group Alleles European Continental Ancestry Group Male Microsatellite Repeats Polymorphism Single Nucleotide Prostatic Neoplasms Research Support N.I.H. Extramural Non-U.S. Gov't |
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African Continental Ancestry Group Alleles European Continental Ancestry Group Male Microsatellite Repeats Polymorphism Single Nucleotide Prostatic Neoplasms Research Support N.I.H. Extramural Non-U.S. Gov't Amundadottir, Laufey T Sulem, Patrick Gudmundsson, Julius Helgason, Agnar Baker, Adam Agnarsson, Bjarni A Sigurdsson, Asgeir Benediktsdottir, Kristrun R Cazier, Jean-Baptiste Sainz, Jesus Jakobsdottir, Margret Kostic, Jelena Magnusdottir, Droplaug N Ghosh, Shyamali Agnarsson, Kari Birgisdottir, Birgitta Le Roux, Louise Olafsdottir, Adalheidur Blondal, Thorarinn Andresdottir, Margret Gretarsdottir, Olafia Svandis Bergthorsson, Jon T Gudbjartsson, Daniel Gylfason, Arnaldur Thorleifsson, Gudmar Manolescu, Andrei Kristjansson, Kristleifur Geirsson, Gudmundur Isaksson, Helgi Douglas, Julie Johansson, Jan-Erik Bälter, Katarina Wiklund, Fredrik Montie, James E Yu, Xiaoying Suarez, Brian K Ober, Carole Cooney, Kathleen A Gronberg, Henrik Catalona, William J Einarsson, Gudmundur V Barkardottir, Rosa B Gulcher, Jeffrey R Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari A common variant associated with prostate cancer in European and African populations |
topic_facet |
African Continental Ancestry Group Alleles European Continental Ancestry Group Male Microsatellite Repeats Polymorphism Single Nucleotide Prostatic Neoplasms Research Support N.I.H. Extramural Non-U.S. Gov't |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. |
format |
Article in Journal/Newspaper |
author |
Amundadottir, Laufey T Sulem, Patrick Gudmundsson, Julius Helgason, Agnar Baker, Adam Agnarsson, Bjarni A Sigurdsson, Asgeir Benediktsdottir, Kristrun R Cazier, Jean-Baptiste Sainz, Jesus Jakobsdottir, Margret Kostic, Jelena Magnusdottir, Droplaug N Ghosh, Shyamali Agnarsson, Kari Birgisdottir, Birgitta Le Roux, Louise Olafsdottir, Adalheidur Blondal, Thorarinn Andresdottir, Margret Gretarsdottir, Olafia Svandis Bergthorsson, Jon T Gudbjartsson, Daniel Gylfason, Arnaldur Thorleifsson, Gudmar Manolescu, Andrei Kristjansson, Kristleifur Geirsson, Gudmundur Isaksson, Helgi Douglas, Julie Johansson, Jan-Erik Bälter, Katarina Wiklund, Fredrik Montie, James E Yu, Xiaoying Suarez, Brian K Ober, Carole Cooney, Kathleen A Gronberg, Henrik Catalona, William J Einarsson, Gudmundur V Barkardottir, Rosa B Gulcher, Jeffrey R Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari |
author_facet |
Amundadottir, Laufey T Sulem, Patrick Gudmundsson, Julius Helgason, Agnar Baker, Adam Agnarsson, Bjarni A Sigurdsson, Asgeir Benediktsdottir, Kristrun R Cazier, Jean-Baptiste Sainz, Jesus Jakobsdottir, Margret Kostic, Jelena Magnusdottir, Droplaug N Ghosh, Shyamali Agnarsson, Kari Birgisdottir, Birgitta Le Roux, Louise Olafsdottir, Adalheidur Blondal, Thorarinn Andresdottir, Margret Gretarsdottir, Olafia Svandis Bergthorsson, Jon T Gudbjartsson, Daniel Gylfason, Arnaldur Thorleifsson, Gudmar Manolescu, Andrei Kristjansson, Kristleifur Geirsson, Gudmundur Isaksson, Helgi Douglas, Julie Johansson, Jan-Erik Bälter, Katarina Wiklund, Fredrik Montie, James E Yu, Xiaoying Suarez, Brian K Ober, Carole Cooney, Kathleen A Gronberg, Henrik Catalona, William J Einarsson, Gudmundur V Barkardottir, Rosa B Gulcher, Jeffrey R Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari |
author_sort |
Amundadottir, Laufey T |
title |
A common variant associated with prostate cancer in European and African populations |
title_short |
A common variant associated with prostate cancer in European and African populations |
title_full |
A common variant associated with prostate cancer in European and African populations |
title_fullStr |
A common variant associated with prostate cancer in European and African populations |
title_full_unstemmed |
A common variant associated with prostate cancer in European and African populations |
title_sort |
common variant associated with prostate cancer in european and african populations |
publisher |
Nature Pub. Co. |
publishDate |
2006 |
url |
http://hdl.handle.net/2336/6357 https://doi.org/10.1038/ng1808 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.nature.com/ng/journal/v38/n6/full/ng1808.html Nat. Genet. 2006, 38(6):652-8 1061-4036 16682969 doi:10.1038/ng1808 PTT12 URO12 http://hdl.handle.net/2336/6357 |
op_doi |
https://doi.org/10.1038/ng1808 |
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Nature Genetics |
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38 |
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6 |
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