Accelerated decline in quadriceps area and Timed Up and Go test performance are associated with hip fracture risk in older adults with impaired kidney function.

• Published in: Experimental Gerontology
• Main Authors: Marques, Elisa A, Elbejjani, Martine, Viana, João L, Gudnason, Vilmundur, Sigurdsson, Gunnar, Lang, Thomas, Sigurdsson, Sigurdur, Aspelund, Thor, Siggeirsdottir, Kristin, Launer, Lenore, Eiriksdottir, Gudny, Harris, Tamara B
• Other Authors: 1Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Portugal. Electronic address: [e-mail]. 2Clinical Research Institute & Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. 3Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Portugal. 4Icelandic Heart Association Research Institute, Kópavogur, Iceland; University of Iceland, Reykjavik, Iceland. 5Icelandic Heart Association Research Institute, Kópavogur, Iceland; University of Iceland, Reykjavik, Iceland; Landspitalinn University Hospital, Reykjavik, Iceland. 6Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. 7Icelandic Heart Association Research Institute, Kópavogur, Iceland. 8Icelandic Heart Association Research Institute, Kópavogur, Iceland; Janus Rehabilitation, Reykjavik, Iceland. 9National Institute on Aging, Intramural Research Program, Laboratory of Epidemiology and Population Sciences, Bethesda, MD, USA.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2021
• Subjects: Chronic kidney disease; Computed tomography; Estimated glomerular filtration rate; Fracture; Muscular function; Mjaðmarbrot; Aldraðir; Nýrnasjúkdómar; Kidney Diseases; Hip Fractures; Aged; Iceland
• Online Access: http://hdl.handle.net/2336/621887; https://doi.org/10.1016/j.exger.2021.111314

To access publisher's full text version of this article click on the hyperlink below Objective: This study aimed to examine whether an accelerated decline in quadriceps cross-sectional area (CSA), attenuation (a surrogate of quality), and strength, as well as lower limb muscular function, are associated with hip fractures in older adults with impaired kidney function. Design: Prospective population-based study. Setting: Community-dwelling old population in Reykjavik, Iceland. Subjects: A total of 875 older adults (mean baseline age 76 years) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study with impaired kidney function. Methods: Quadriceps CSA and density were determined using computed tomography (CT), knee extension strength was measured with an isometric dynamometer chair, and muscular function was assessed using the Timed Up and Go (TUG) test. All muscle-related measurements were assessed twice over a mean follow-up of 5.2 years. Data on hip fracture incidence was obtained from medical records during a maximum of 8.4 years of follow-up time. Results: Fully adjusted cox-proportional hazard regression models showed that a faster decline in quadriceps CSA and TUG test performance were significantly associated with increased hip fracture risk (HR = 1.55, 95% CI = 1.02-2.36, and HR = 1.80, 95% CI = 1.19-2.72, respectively). A faster decrease in quadriceps density and isometric knee extension strength were not associated with fracture risk. Conclusions: Accelerated decline in CT-derived quadriceps CSA and muscular function, as measured by the TUG test's performance, are predictive of hip fracture risk in older adults with impaired kidney function. TUG test is a simple measure and easily included in routine medical examinations, compared to CT scans, which seems to be useful for identifying a subgroup of individuals with high risk of fracture. Keywords: Chronic kidney disease; Computed tomography; Estimated glomerular filtration rate; Fracture; Muscular function. United States Department of ...