Computed tomography-based skeletal muscle and adipose tissue attenuation: Variations by age, sex, and muscle.

• Published in: Experimental Gerontology
• Main Authors: Figueiredo, Pedro, Marques, Elisa A, Gudnason, Vilmundur, Lang, Thomas, Sigurdsson, Sigurdur, Jonsson, Palmi V, Aspelund, Thor, Siggeirsdottir, Kristin, Launer, Lenore, Eiriksdottir, Gudny, Harris, Tamara B
• Other Authors: 1Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Research Center in Sports Sciences, Health Sciences and Human Development - CIDESD, University Institute of Maia - ISMAI, Maia, Portugal; Portugal Football School, Portuguese Football Federation, Oeiras, Portugal. Electronic address: [e-mail]. 2Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Research Center in Sports Sciences, Health Sciences and Human Development - CIDESD, University Institute of Maia - ISMAI, Maia, Portugal. 3Icelandic Heart Association Research Institute, Kópavogur, Iceland; University of Iceland, Reykjavik, Iceland. 4Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. 5Icelandic Heart Association Research Institute, Kópavogur, Iceland. 6Landspitalinn University Hospital, Reykjavik, Iceland. 7Icelandic Heart Association Research Institute, Kópavogur, Iceland; Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland. 8Icelandic Heart Association Research Institute, Kópavogur, Iceland; Janus Rehabilitation, Reykjavik, Iceland. 9Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2021
• Subjects: Computed tomography; Fat; Thigh muscles; Tissue density; Trunk muscles; Öldrun; Vöðvar; Holdafar; Muscle; Skeletal; Adipose Tissue; Aging; Iceland
• Online Access: http://hdl.handle.net/2336/621886; https://doi.org/10.1016/j.exger.2021.111306

To access publisher's full text version of this article click on the hyperlink below Objective: This study aimed to investigate how skeletal muscle attenuation and adipose tissue (AT) attenuation of the quadriceps, hamstrings, paraspinal muscle groups and the psoas muscle vary according to the targeted muscles, sex, and age. Design: Population-based cross-sectional study. Setting: Community-dwelling old population in Reykjavik, Iceland. Subjects: A total of 5331 older adults (42.8% women), aged 66-96 years from the Age, Gene/Environment Susceptibility (AGES)- Reykjavik Study, who participated in the baseline visit (between 2002 and 2006) and had valid thigh and abdominal computed tomography (CT) scans were studied. Methods: Muscle attenuation and AT attenuation of the quadriceps, hamstrings, paraspinal muscle groups and the psoas muscle were determined using CT. Linear mixed model analysis of variance was performed for each sex, with skeletal muscle or AT attenuation as the dependent variable. Results: Muscle attenuation decreased, and AT attenuation increased with age in both sexes, and these differences were specific for each muscle, although not in all age groups. Age-related differences in muscle and AT attenuation varied with specific muscle. In general, for both sexes, skeletal muscle attenuation of the hamstrings declined more than average with age. Men and women displayed a different pattern in the age differences in AT attenuation for each muscle. Conclusions: Our data support the hypotheses that skeletal muscle attenuation decreases, and AT attenuation increases with aging. In addition, our data add new evidence, supporting that age-related differences in skeletal muscle and AT attenuation vary between muscles. Keywords: Computed tomography; Fat; Thigh muscles; Tissue density; Trunk muscles. United States Department of Health & Human Services National Institutes of Health (NIH) - USA United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National ...