Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study.

• Published in: Osteoporosis International
• Main Authors: Skuladottir, S S, Ramel, A, Hjaltadottir, I, Launer, L J, Cotch, M F, Siggeirsdottir, K, Gudnason, V, Sigurdsson, G, Steingrimsdottir, L, Halldorsson, T
• Other Authors: 1The Icelandic Gerontological Research Institute, Tungata 5, 101, Reykjavik, Iceland. [e-mail]. 2Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. [e-mail]. 3Landspitali National University Hospital of Iceland, Reykjavik, Iceland. [e-mail]. 4The Icelandic Gerontological Research Institute, Tungata 5, 101, Reykjavik, Iceland. 5Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. 6Landspitali National University Hospital of Iceland, Reykjavik, Iceland. 7Faculty of Nursing, University of Iceland, Reykjavik, Iceland. 8Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MA, USA. 9Division of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Bethesda, MA, USA. 10Icelandic Heart Association Research Institute, Kopavogur, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer 2020
• Subjects: Aging; Biomarkers; Body composition; Hip fracture; Physical function; Mjaðmarbrot; Beinbrot; Byltur; Öldrun; Líkamsástand; Hip Fractures; Iceland
• Online Access: http://hdl.handle.net/2336/621524; https://doi.org/10.1007/s00198-020-05567-x

United States Department of Health & Human Services National Institutes of Health (NIH) - USA National Institute on Aging Intramural Research Program, the National Eye Institute, USA ZIAEY000401 Hjartavernd (The Icelandic Heart Association) Althingi (Icelandic Parliament) St. Josef's Hospital Fund, Reykjavik, Iceland Landspitali University Hospital Research Fund Icelandic Gerontological Society Research Fund Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund Poor physical function and body composition my partly predict the risk of falls leading to fracture regardless of bone mineral density. Introduction: To examine the relationship between body composition, physical function, and other markers of health with hip fractures in older community-dwelling Icelandic adults. Methods: A prospective cohort of 4782 older adults from the AGES-Reykjavik study. Baseline recruitment took place between 2002 and 2006, and information on hip fractures occurring through 2012 was extracted from clinical records. Using multivariate regression analyses, baseline measures of bone health, physical function, and body composition were compared between those who later experienced hip fractures and to those who did not. Associations with the risk of fractures were quantified using Cox regression. Results: Mean age was 76.3 years at baseline. After adjustment for age, regression showed that male hip fracture cases compared with non-cases had (mean (95% confidence interval)) significantly lower thigh muscle cross-sectional area - 5.6 cm2 (- 10.2, - 1.1), poorer leg strength - 28 N (- 49, - 7), and decreased physical function as measured by longer timed up and go test 1.1 s (0.5, 1.7). After adjustment for age, female cases had, compared with non-cases, lower body mass index - 1.5 kg/m2 (- 2.1, - 0.9), less lean mass - 1.6 kg (- 2.5, - 0.8), thigh muscle cross-sectional area - 4.4 cm2 (- 6.5, - 2.3), and worse leg strength - 16 N (- 25, - 6). These differences largely persisted after further adjustment for bone mineral ...