Spread of SARS-CoV-2 in the Icelandic Population.
To access publisher's full text version of this article click on the hyperlink below Context: Radical cystectomy and pelvic lymph node dissection (RC and PLND) are an essential part of the treatment paradigm in high risk bladder cancer. However, these patients have high rates of morbidity and m...
Published in: | New England Journal of Medicine |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Boston, Massachusetts Medical Society
2020
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Online Access: | http://hdl.handle.net/2336/621485 https://doi.org/10.1056/NEJMoa2006100 |
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COVID-19 Smitleiðir Ísland Coronavirus Infections Iceland Epidemiology |
spellingShingle |
COVID-19 Smitleiðir Ísland Coronavirus Infections Iceland Epidemiology Gudbjartsson, Daniel F Helgason, Agnar Jonsson, Hakon Magnusson, Olafur T Melsted, Pall Norddahl, Gudmundur L Saemundsdottir, Jona Sigurdsson, Asgeir Sulem, Patrick Agustsdottir, Arna B Eiriksdottir, Berglind Fridriksdottir, Run Gardarsdottir, Elisabet E Georgsson, Gudmundur Gretarsdottir, Olafia S Gudmundsson, Kjartan R Gunnarsdottir, Thora R Gylfason, Arnaldur Holm, Hilma Jensson, Brynjar O Jonasdottir, Aslaug Jonsson, Frosti Josefsdottir, Kamilla S Kristjansson, Thordur Magnusdottir, Droplaug N le Roux, Louise Sigmundsdottir, Gudrun Sveinbjornsson, Gardar Sveinsdottir, Kristin E Sveinsdottir, Maney Thorarensen, Emil A Thorbjornsson, Bjarni Löve, Arthur Masson, Gisli Jonsdottir, Ingileif Möller, Alma D Gudnason, Thorolfur Kristinsson, Karl G Thorsteinsdottir, Unnur Stefansson, Kari Spread of SARS-CoV-2 in the Icelandic Population. |
topic_facet |
COVID-19 Smitleiðir Ísland Coronavirus Infections Iceland Epidemiology |
description |
To access publisher's full text version of this article click on the hyperlink below Context: Radical cystectomy and pelvic lymph node dissection (RC and PLND) are an essential part of the treatment paradigm in high risk bladder cancer. However, these patients have high rates of morbidity and mortality related both to the treatment and to the disease.Objective: To provide overview of current literature about clinical markers that can be used to predict and improve BC-patient outcomes at the time of RC and PLND and to study if they are properly validated.Evidence acquisition: A systematic literature search was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria between January 1990 and October 2018 to identify English written original and review articles relevant to this topic. Prospective and retrospective studies were included.Evidence synthesis: There are several risk factors identified from non-randomised trials that can be improved before surgery to reduce perioperative mortality and morbidity. These include poor nutritional status, anaemia, renal function and smoking. Preoperative nomograms have also been developed to help decision-making and to inform patients about the risks of surgery. They can be used to estimate risk of postoperative mortality after RC and PLND with accuracy varying from 70 to 86%. These nomograms are largely based on retrospective data. Likewise, nomograms developed to calculate estimates about patient's overall and cancer specific survival have the same limitations.Conclusion: Clinical markers to predict morbidity, mortality and survival in patients with bladder cancer treated with RC and PLND may help to improve patient outcomes and treatment decision-making, but available data come from small retrospective trials and have not been properly validated. Prospective, multi-centre studies are needed to implement and disseminate predictive clinical markers and nomograms such that they can be utilised in treatment decision-making ... |
author2 |
1From deCODE Genetics-Amgen (D.F.G., A.H., H.J., O.T.M., P.M., G.L.N., J.S., A.S., P.S., A.B.A., B.E., R.F., E.E.G., G.G., K.R.G., A.G., H.H., B.O.J., A.J., F.J., T.K., D.N.M., L.R., G. Sveinbjornsson, K.E.S., E.A.T., B.T., G.M., I.J., U.T., K.S.), the School of Engineering and Natural Sciences (D.F.G., P.M.), the Department of Anthropology (A.H.), the Faculty of Medicine, School of Health Sciences (A.L., I.J., K.G.K., U.T., K.S.), and the BioMedical Center of the University of Iceland (K.G.K.), University of Iceland, the Department of Clinical Microbiology, Landspitali-National University Hospital (O.S.G., T.R.G., M.S., A.L., K.G.K.) and the Directorate of Health (K.S.J., G. Sigmundsdottir, A.D.M., T.G.) - all in Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Gudbjartsson, Daniel F Helgason, Agnar Jonsson, Hakon Magnusson, Olafur T Melsted, Pall Norddahl, Gudmundur L Saemundsdottir, Jona Sigurdsson, Asgeir Sulem, Patrick Agustsdottir, Arna B Eiriksdottir, Berglind Fridriksdottir, Run Gardarsdottir, Elisabet E Georgsson, Gudmundur Gretarsdottir, Olafia S Gudmundsson, Kjartan R Gunnarsdottir, Thora R Gylfason, Arnaldur Holm, Hilma Jensson, Brynjar O Jonasdottir, Aslaug Jonsson, Frosti Josefsdottir, Kamilla S Kristjansson, Thordur Magnusdottir, Droplaug N le Roux, Louise Sigmundsdottir, Gudrun Sveinbjornsson, Gardar Sveinsdottir, Kristin E Sveinsdottir, Maney Thorarensen, Emil A Thorbjornsson, Bjarni Löve, Arthur Masson, Gisli Jonsdottir, Ingileif Möller, Alma D Gudnason, Thorolfur Kristinsson, Karl G Thorsteinsdottir, Unnur Stefansson, Kari |
author_facet |
Gudbjartsson, Daniel F Helgason, Agnar Jonsson, Hakon Magnusson, Olafur T Melsted, Pall Norddahl, Gudmundur L Saemundsdottir, Jona Sigurdsson, Asgeir Sulem, Patrick Agustsdottir, Arna B Eiriksdottir, Berglind Fridriksdottir, Run Gardarsdottir, Elisabet E Georgsson, Gudmundur Gretarsdottir, Olafia S Gudmundsson, Kjartan R Gunnarsdottir, Thora R Gylfason, Arnaldur Holm, Hilma Jensson, Brynjar O Jonasdottir, Aslaug Jonsson, Frosti Josefsdottir, Kamilla S Kristjansson, Thordur Magnusdottir, Droplaug N le Roux, Louise Sigmundsdottir, Gudrun Sveinbjornsson, Gardar Sveinsdottir, Kristin E Sveinsdottir, Maney Thorarensen, Emil A Thorbjornsson, Bjarni Löve, Arthur Masson, Gisli Jonsdottir, Ingileif Möller, Alma D Gudnason, Thorolfur Kristinsson, Karl G Thorsteinsdottir, Unnur Stefansson, Kari |
author_sort |
Gudbjartsson, Daniel F |
title |
Spread of SARS-CoV-2 in the Icelandic Population. |
title_short |
Spread of SARS-CoV-2 in the Icelandic Population. |
title_full |
Spread of SARS-CoV-2 in the Icelandic Population. |
title_fullStr |
Spread of SARS-CoV-2 in the Icelandic Population. |
title_full_unstemmed |
Spread of SARS-CoV-2 in the Icelandic Population. |
title_sort |
spread of sars-cov-2 in the icelandic population. |
publisher |
Boston, Massachusetts Medical Society |
publishDate |
2020 |
url |
http://hdl.handle.net/2336/621485 https://doi.org/10.1056/NEJMoa2006100 |
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ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Prisma |
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Prisma |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
The New England journal of medicine 382 24 2302 2315 United States |
op_relation |
https://www.nejm.org/doi/10.1056/NEJMoa2006100?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175425/ Gudbjartsson DF, Helgason A, Jonsson H, et al. Spread of SARS-CoV-2 in the Icelandic Population. N Engl J Med. 2020;382(24):2302-2315. doi:10.1056/NEJMoa2006100 32289214 doi:10.1056/NEJMoa2006100 http://hdl.handle.net/2336/621485 1533-4406 The New England journal of medicine |
op_rights |
Copyright © 2020 Massachusetts Medical Society. Open Access - Opinn aðgangur |
op_doi |
https://doi.org/10.1056/NEJMoa2006100 |
container_title |
New England Journal of Medicine |
container_volume |
382 |
container_issue |
24 |
container_start_page |
2302 |
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2315 |
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1766042525156507648 |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/621485 2023-05-15T16:52:20+02:00 Spread of SARS-CoV-2 in the Icelandic Population. Gudbjartsson, Daniel F Helgason, Agnar Jonsson, Hakon Magnusson, Olafur T Melsted, Pall Norddahl, Gudmundur L Saemundsdottir, Jona Sigurdsson, Asgeir Sulem, Patrick Agustsdottir, Arna B Eiriksdottir, Berglind Fridriksdottir, Run Gardarsdottir, Elisabet E Georgsson, Gudmundur Gretarsdottir, Olafia S Gudmundsson, Kjartan R Gunnarsdottir, Thora R Gylfason, Arnaldur Holm, Hilma Jensson, Brynjar O Jonasdottir, Aslaug Jonsson, Frosti Josefsdottir, Kamilla S Kristjansson, Thordur Magnusdottir, Droplaug N le Roux, Louise Sigmundsdottir, Gudrun Sveinbjornsson, Gardar Sveinsdottir, Kristin E Sveinsdottir, Maney Thorarensen, Emil A Thorbjornsson, Bjarni Löve, Arthur Masson, Gisli Jonsdottir, Ingileif Möller, Alma D Gudnason, Thorolfur Kristinsson, Karl G Thorsteinsdottir, Unnur Stefansson, Kari 1From deCODE Genetics-Amgen (D.F.G., A.H., H.J., O.T.M., P.M., G.L.N., J.S., A.S., P.S., A.B.A., B.E., R.F., E.E.G., G.G., K.R.G., A.G., H.H., B.O.J., A.J., F.J., T.K., D.N.M., L.R., G. Sveinbjornsson, K.E.S., E.A.T., B.T., G.M., I.J., U.T., K.S.), the School of Engineering and Natural Sciences (D.F.G., P.M.), the Department of Anthropology (A.H.), the Faculty of Medicine, School of Health Sciences (A.L., I.J., K.G.K., U.T., K.S.), and the BioMedical Center of the University of Iceland (K.G.K.), University of Iceland, the Department of Clinical Microbiology, Landspitali-National University Hospital (O.S.G., T.R.G., M.S., A.L., K.G.K.) and the Directorate of Health (K.S.J., G. Sigmundsdottir, A.D.M., T.G.) - all in Reykjavik, Iceland. 2020-08 http://hdl.handle.net/2336/621485 https://doi.org/10.1056/NEJMoa2006100 en eng Boston, Massachusetts Medical Society https://www.nejm.org/doi/10.1056/NEJMoa2006100?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175425/ Gudbjartsson DF, Helgason A, Jonsson H, et al. Spread of SARS-CoV-2 in the Icelandic Population. N Engl J Med. 2020;382(24):2302-2315. doi:10.1056/NEJMoa2006100 32289214 doi:10.1056/NEJMoa2006100 http://hdl.handle.net/2336/621485 1533-4406 The New England journal of medicine Copyright © 2020 Massachusetts Medical Society. Open Access - Opinn aðgangur The New England journal of medicine 382 24 2302 2315 United States COVID-19 Smitleiðir Ísland Coronavirus Infections Iceland Epidemiology Article Other 2020 ftlandspitaliuni https://doi.org/10.1056/NEJMoa2006100 2022-05-29T08:22:33Z To access publisher's full text version of this article click on the hyperlink below Context: Radical cystectomy and pelvic lymph node dissection (RC and PLND) are an essential part of the treatment paradigm in high risk bladder cancer. However, these patients have high rates of morbidity and mortality related both to the treatment and to the disease.Objective: To provide overview of current literature about clinical markers that can be used to predict and improve BC-patient outcomes at the time of RC and PLND and to study if they are properly validated.Evidence acquisition: A systematic literature search was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria between January 1990 and October 2018 to identify English written original and review articles relevant to this topic. Prospective and retrospective studies were included.Evidence synthesis: There are several risk factors identified from non-randomised trials that can be improved before surgery to reduce perioperative mortality and morbidity. These include poor nutritional status, anaemia, renal function and smoking. Preoperative nomograms have also been developed to help decision-making and to inform patients about the risks of surgery. They can be used to estimate risk of postoperative mortality after RC and PLND with accuracy varying from 70 to 86%. These nomograms are largely based on retrospective data. Likewise, nomograms developed to calculate estimates about patient's overall and cancer specific survival have the same limitations.Conclusion: Clinical markers to predict morbidity, mortality and survival in patients with bladder cancer treated with RC and PLND may help to improve patient outcomes and treatment decision-making, but available data come from small retrospective trials and have not been properly validated. Prospective, multi-centre studies are needed to implement and disseminate predictive clinical markers and nomograms such that they can be utilised in treatment decision-making ... Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) New England Journal of Medicine 382 24 2302 2315 |