The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy.
To access publisher's full text version of this article click on the hyperlink below OBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur mo...
Published in: | Scandinavian Journal of Gastroenterology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Taylor & Francis
2019
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Online Access: | http://hdl.handle.net/2336/621086 https://doi.org/10.1080/00365521.2018.1481997 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/621086 2023-05-15T16:49:08+02:00 The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. Halldorsson, Matthias Orn Hauptmann, Michael Snaebjornsson, Petur Haraldsdóttir, Kristín Huld Aspelund, Thor Gudmundsson, Elias Freyr Gudnason, Vilmundur Jonasson, Jon Gunnlaugur Haraldsdottir, Sigurdis a Faculty of Medicine , University of Iceland , Reykjavík , Iceland. 2 b Department of Epidemiology and Biostatistics , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 3 c Department of Pathology , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 4 d Landspitali University Hospital Iceland , Reykjavík , Iceland. 5 e University of Iceland , Reykjavík , Iceland. 6 f Icelandic Heart Association , Kópavogur , Iceland. 7 g Department of Pathology , Landspitali-University Hospital , Iceland. 8 h Department of Internal Medicine , Stanford University , Stanford , CA , USA. 2019-09 http://hdl.handle.net/2336/621086 https://doi.org/10.1080/00365521.2018.1481997 en eng Taylor & Francis https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1481997 The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. 2019, 53(8):972-975 Scand J Gastroenterol 1502-7708 30010450 doi:10.1080/00365521.2018.1481997 http://hdl.handle.net/2336/621086 Scandinavian Journal of Gastroenterology Landspitali Access - LSH-aðgangur Scandinavian journal of gastroenterology MLH1 hypermethylation Microsatellite instability carcinogenesis of bile acids cholecystectomy colorectal cancer risk factors population-based Ristilkrabbamein Gallblöðrunám Colorectal Neoplasms Article 2019 ftlandspitaliuni https://doi.org/10.1080/00365521.2018.1481997 2022-05-29T08:22:28Z To access publisher's full text version of this article click on the hyperlink below OBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the risk of a dMMR CRC by comparing CCY incidence in patients with dMMR CRC and proficient MMR (pMMR) CRC to unaffected controls. MATERIALS AND METHODS: All patients diagnosed with CRC in Iceland from 2000 to 2009 (n = 1171) were included. They had previously been screened for dMMR by immunohistochemistry (n = 129 were dMMR). Unaffected age- and sex-matched controls (n = 17,460) were obtained from large Icelandic cohort studies. Subjects were cross-referenced with all pathology databases in Iceland to establish who had undergone CCY. Odds ratios were calculated using unconditional logistic regression. RESULTS: Eighteen (13.7%) dMMR CRC cases and 90 (8.7%) pMMR CRC cases had undergone CCY compared to 1532 (8.8%) controls. CCY-related odds ratios (OR) were 1.06 (95% CI 0.90-1.26, p = .577) for all CRC, 1.16 (95% CI 0.66-2.05 p = .602) for dMMR CRCand 1.04 (95% CI 0.83-1.29, p = .744) for pMMR CRC. Furthermore, OR for dMMR CRC was 0.51 (95% CI 0.16-1.67, p = .266), 2.04 (95% CI 0.92-4.50, p = .080) and 1.08 (95% CI 0.40-2.89, p = .875) <10 years, 10-20 years and >20 years after a CCY, respectively. CONCLUSIONS: There was no evidence of increased risk of developing dMMR CRC after CCY although a borderline significantly increased 2-fold risk was observed 10-20 years after CCY. Larger studies are warranted to examine this further. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Gastroenterology 53 8 972 975 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
MLH1 hypermethylation Microsatellite instability carcinogenesis of bile acids cholecystectomy colorectal cancer risk factors population-based Ristilkrabbamein Gallblöðrunám Colorectal Neoplasms |
spellingShingle |
MLH1 hypermethylation Microsatellite instability carcinogenesis of bile acids cholecystectomy colorectal cancer risk factors population-based Ristilkrabbamein Gallblöðrunám Colorectal Neoplasms Halldorsson, Matthias Orn Hauptmann, Michael Snaebjornsson, Petur Haraldsdóttir, Kristín Huld Aspelund, Thor Gudmundsson, Elias Freyr Gudnason, Vilmundur Jonasson, Jon Gunnlaugur Haraldsdottir, Sigurdis The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
topic_facet |
MLH1 hypermethylation Microsatellite instability carcinogenesis of bile acids cholecystectomy colorectal cancer risk factors population-based Ristilkrabbamein Gallblöðrunám Colorectal Neoplasms |
description |
To access publisher's full text version of this article click on the hyperlink below OBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the risk of a dMMR CRC by comparing CCY incidence in patients with dMMR CRC and proficient MMR (pMMR) CRC to unaffected controls. MATERIALS AND METHODS: All patients diagnosed with CRC in Iceland from 2000 to 2009 (n = 1171) were included. They had previously been screened for dMMR by immunohistochemistry (n = 129 were dMMR). Unaffected age- and sex-matched controls (n = 17,460) were obtained from large Icelandic cohort studies. Subjects were cross-referenced with all pathology databases in Iceland to establish who had undergone CCY. Odds ratios were calculated using unconditional logistic regression. RESULTS: Eighteen (13.7%) dMMR CRC cases and 90 (8.7%) pMMR CRC cases had undergone CCY compared to 1532 (8.8%) controls. CCY-related odds ratios (OR) were 1.06 (95% CI 0.90-1.26, p = .577) for all CRC, 1.16 (95% CI 0.66-2.05 p = .602) for dMMR CRCand 1.04 (95% CI 0.83-1.29, p = .744) for pMMR CRC. Furthermore, OR for dMMR CRC was 0.51 (95% CI 0.16-1.67, p = .266), 2.04 (95% CI 0.92-4.50, p = .080) and 1.08 (95% CI 0.40-2.89, p = .875) <10 years, 10-20 years and >20 years after a CCY, respectively. CONCLUSIONS: There was no evidence of increased risk of developing dMMR CRC after CCY although a borderline significantly increased 2-fold risk was observed 10-20 years after CCY. Larger studies are warranted to examine this further. |
author2 |
a Faculty of Medicine , University of Iceland , Reykjavík , Iceland. 2 b Department of Epidemiology and Biostatistics , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 3 c Department of Pathology , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 4 d Landspitali University Hospital Iceland , Reykjavík , Iceland. 5 e University of Iceland , Reykjavík , Iceland. 6 f Icelandic Heart Association , Kópavogur , Iceland. 7 g Department of Pathology , Landspitali-University Hospital , Iceland. 8 h Department of Internal Medicine , Stanford University , Stanford , CA , USA. |
format |
Article in Journal/Newspaper |
author |
Halldorsson, Matthias Orn Hauptmann, Michael Snaebjornsson, Petur Haraldsdóttir, Kristín Huld Aspelund, Thor Gudmundsson, Elias Freyr Gudnason, Vilmundur Jonasson, Jon Gunnlaugur Haraldsdottir, Sigurdis |
author_facet |
Halldorsson, Matthias Orn Hauptmann, Michael Snaebjornsson, Petur Haraldsdóttir, Kristín Huld Aspelund, Thor Gudmundsson, Elias Freyr Gudnason, Vilmundur Jonasson, Jon Gunnlaugur Haraldsdottir, Sigurdis |
author_sort |
Halldorsson, Matthias Orn |
title |
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
title_short |
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
title_full |
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
title_fullStr |
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
title_full_unstemmed |
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
title_sort |
risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
http://hdl.handle.net/2336/621086 https://doi.org/10.1080/00365521.2018.1481997 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Scandinavian journal of gastroenterology |
op_relation |
https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1481997 The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. 2019, 53(8):972-975 Scand J Gastroenterol 1502-7708 30010450 doi:10.1080/00365521.2018.1481997 http://hdl.handle.net/2336/621086 Scandinavian Journal of Gastroenterology |
op_rights |
Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1080/00365521.2018.1481997 |
container_title |
Scandinavian Journal of Gastroenterology |
container_volume |
53 |
container_issue |
8 |
container_start_page |
972 |
op_container_end_page |
975 |
_version_ |
1766039223713923072 |