Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study.
To access publisher's full text version of this article click on the hyperlink below AIM: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population-based obser...
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Online Access: | http://hdl.handle.net/2336/621064 https://doi.org/10.1111/apa.14724 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/621064 2023-05-15T16:48:32+02:00 Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G Haraldsson, Ásgeir 1 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2 Department of Clinical Microbiology, Landspítali University Hospital, Reykjavik, Iceland. 3 Department of Mathematics, University of Iceland, Reykjavik, Iceland. 4 Children's Hospital Iceland, Landspítali University Hospital, Reykjavik, Iceland. 2019-09 http://hdl.handle.net/2336/621064 https://doi.org/10.1111/apa.14724 en eng Wiley https://onlinelibrary.wiley.com/doi/full/10.1111/apa.14724 Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. 2019, 108(8):1527-1534 Acta Paediatr 1651-2227 30667099 doi:10.1111/apa.14724 http://hdl.handle.net/2336/621064 Acta Paediatrica National Consortium - Landsaðgangur Acta paediatrica (Oslo, Norway : 1992) Streptococcus pneumoniae Conjugate vaccines Middle ear ventilation Otitis media PHiD-CV vaccine Eyrnabólga Bólusetningar Pneumococcal Vaccines Article 2019 ftlandspitaliuni https://doi.org/10.1111/apa.14724 2022-05-29T08:22:28Z To access publisher's full text version of this article click on the hyperlink below AIM: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. RESULTS: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was -6% (95% CI -16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. CONCLUSION: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. GlaxoSmithKline Biologicals SA Landspitali University Hospital Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Acta Paediatrica 108 8 1527 1534 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Streptococcus pneumoniae Conjugate vaccines Middle ear ventilation Otitis media PHiD-CV vaccine Eyrnabólga Bólusetningar Pneumococcal Vaccines |
spellingShingle |
Streptococcus pneumoniae Conjugate vaccines Middle ear ventilation Otitis media PHiD-CV vaccine Eyrnabólga Bólusetningar Pneumococcal Vaccines Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G Haraldsson, Ásgeir Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
topic_facet |
Streptococcus pneumoniae Conjugate vaccines Middle ear ventilation Otitis media PHiD-CV vaccine Eyrnabólga Bólusetningar Pneumococcal Vaccines |
description |
To access publisher's full text version of this article click on the hyperlink below AIM: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. METHODS: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. RESULTS: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was -6% (95% CI -16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. CONCLUSION: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. GlaxoSmithKline Biologicals SA Landspitali University Hospital Research Fund |
author2 |
1 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2 Department of Clinical Microbiology, Landspítali University Hospital, Reykjavik, Iceland. 3 Department of Mathematics, University of Iceland, Reykjavik, Iceland. 4 Children's Hospital Iceland, Landspítali University Hospital, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G Haraldsson, Ásgeir |
author_facet |
Eythorsson, Elias Sigurdsson, Samuel Erlendsdóttir, Helga Hrafnkelsson, Birgir Kristinsson, Karl G Haraldsson, Ásgeir |
author_sort |
Eythorsson, Elias |
title |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
title_short |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
title_full |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
title_fullStr |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
title_full_unstemmed |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
title_sort |
increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. |
publisher |
Wiley |
publishDate |
2019 |
url |
http://hdl.handle.net/2336/621064 https://doi.org/10.1111/apa.14724 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta paediatrica (Oslo, Norway : 1992) |
op_relation |
https://onlinelibrary.wiley.com/doi/full/10.1111/apa.14724 Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study. 2019, 108(8):1527-1534 Acta Paediatr 1651-2227 30667099 doi:10.1111/apa.14724 http://hdl.handle.net/2336/621064 Acta Paediatrica |
op_rights |
National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1111/apa.14724 |
container_title |
Acta Paediatrica |
container_volume |
108 |
container_issue |
8 |
container_start_page |
1527 |
op_container_end_page |
1534 |
_version_ |
1766038613594734592 |