Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals.

• Published in: International Archives of Allergy and Immunology
• Main Authors: Magnusdottir, Helga, Vidarsdóttir, Anna Gudrun, Ludviksson, Bjorn Runar, Clausen, Michael, Lund, Sigrun Helga, Jensen, Anders B, Sigurdardottir, Sigurveig T
• Other Authors: 1 Faculty of Medicine, University of Iceland, Reykjavík, Iceland. 2 Department of Immunology, Landspitali University Hospital, Reykavík, Iceland. 3 Allergy Outpatient Department, Landspitali University Hospital, Reyjavík, Iceland. 4 Children's Hospital of Iceland, Reykjavík, Iceland. 5 Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland. 6 Thermo Fisher Scientific, Allerd, Denmark. 7 Faculty of Medicine, University of Iceland, Reykjavík, [e-mail]. 8 Department of Immunology, Landspitali University Hospital, Reykavík, [e-mail]. 9 Allergy Outpatient Department, Landspitali University Hospital, Reyjavík, [e-mail].
• Format: Article in Journal/Newspaper
• Language: English
• Published: Karger 2019
• Subjects: Ara h 2; Ara h 6; Food allergy; Peanut allergy; Peanut sensitization; Fæðuofnæmi; Hnetuofnæmi; Jarðhnetur; Food Hypersensitivity; Peanut Hypersensitivity; Arachis; Iceland
• Online Access: http://hdl.handle.net/2336/620855; https://doi.org/10.1159/000493327

To access publisher's full text version of this article click on the hyperlink below Of the major peanut allergens, sensitivity to Ara h 2 has the highest prediction for clinical allergy. In this study, we evaluated sensitization to peanut components in Iceland and related Ara h 2-negative sensitization to clinical allergy. Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Bet v 1 IgEs were measured (ImmunoCAP) in 220 peanut IgE (Pn-IgE)-positive serum samples. Ara h 2 IgE-negative individuals were invited to an open peanut challenge and evaluated for Ara h 6 and 9 sensitization (ISAC microarray). The Ara h 2 IgE-negative group (52.3%, 115/220) was older (p = 0.04) and more likely to have a history of pollen allergy than the Ara h 2-positive group (p < 0.001). Of the Ara h 2-negative participants, 24.3% were already consuming peanuts and 38.3% were unavailable. Of the 43 who underwent an open peanut challenge, 79% were negative, 14% were positive, and 7% were inconclusive. Those who reacted to peanuts had a higher Ara h 1 IgE than that of the tolerant participants, and 3 were positive to Ara h 6 IgE, and 2 of those subjects were monosensitized. Ara h 8 may have caused a positive reaction, while Ara h 9 did not. Half of the peanut-sensitized individuals in Iceland were not sensitized to the major allergen Ara h 2. Ara h 1, Ara h 3, and Ara h 6 sensitizations resulted in a positive open peanut challenge and they are therefore clinically important for individuals with a peanut allergy in Iceland.