Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.

To access publisher's full text version of this article click on the hyperlink below Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. To assess the prevalence of early childhood wheeze acros...

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Published in:Thorax
Main Authors: Selby, Anna, Munro, Alasdair, Grimshaw, Kate E, Cornelius, Victoria, Keil, Thomas, Grabenhenrich, Linus, Clausen, Michael, Dubakiene, Ruta, Fiocchi, Alessandro, Kowalski, Marek L, Papadopoulos, Nikolaos G, Reche, Marta, Sigurdardottir, Sigurveig T, Sprikkelman, Aline B, Xepapadaki, Paraskevi, Mills, E N Clare, Beyer, Kirsten, Roberts, Graham
Other Authors: 1 Clinical and Experimental Sciences and Human Development and Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, UK. 2 Department of Paediatrics, Royal Hampshire County Hospital, Winchester, UK. 3 Department of Nutrition and Dietetics, Southampton Children's Hospital, Southampton, UK. 4 Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK. 5 Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Berlin, Germany. 6 Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. 7 Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. 8 Department for Dermatology, Venerology and Allergology, Charité University Medical Centre, Berlin, Germany. 9 Children's Hospital, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 10 Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 11 Division of Allergy, Ospedale Pediatrico Bambino Gesu, Roma, Italy. 12 Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. 13 Allergy Unit, 2nd Paediatric Clinic, University of Athens, Athens, Greece. 14 Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK. 15 Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. 16 Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 17 Department of Pediatric Pulmonology and Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands. 18 Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. 19 Department of Paediatric Pulmonology and Immunology, Charité University Medical Centre, Berlin, Germany. 20 NIHR Southampton Respiratory Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 21 The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
Format: Article in Journal/Newspaper
Language:English
Published: BMJ Publishing Group 2019
Subjects:
Online Access:http://hdl.handle.net/2336/620781
https://doi.org/10.1136/thoraxjnl-2016-209429
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institution Open Polar
collection Hirsla - Landspítali University Hospital research archive
op_collection_id ftlandspitaliuni
language English
topic asthma epidemiology
paediatric asthma
Öndunarfærasjúkdómar
Astmi
Leikskólabörn
Respiratory Sounds
Asthma
Child
Preschool
spellingShingle asthma epidemiology
paediatric asthma
Öndunarfærasjúkdómar
Astmi
Leikskólabörn
Respiratory Sounds
Asthma
Child
Preschool
Selby, Anna
Munro, Alasdair
Grimshaw, Kate E
Cornelius, Victoria
Keil, Thomas
Grabenhenrich, Linus
Clausen, Michael
Dubakiene, Ruta
Fiocchi, Alessandro
Kowalski, Marek L
Papadopoulos, Nikolaos G
Reche, Marta
Sigurdardottir, Sigurveig T
Sprikkelman, Aline B
Xepapadaki, Paraskevi
Mills, E N Clare
Beyer, Kirsten
Roberts, Graham
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
topic_facet asthma epidemiology
paediatric asthma
Öndunarfærasjúkdómar
Astmi
Leikskólabörn
Respiratory Sounds
Asthma
Child
Preschool
description To access publisher's full text version of this article click on the hyperlink below Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. European Commission under the 6th Framework Programme Integrated Approaches to Food Allergy and Allergy Risk Management, a 7th Framework Collaborative Project UK Food Standards Agency
author2 1 Clinical and Experimental Sciences and Human Development and Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, UK. 2 Department of Paediatrics, Royal Hampshire County Hospital, Winchester, UK. 3 Department of Nutrition and Dietetics, Southampton Children's Hospital, Southampton, UK. 4 Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK. 5 Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Berlin, Germany. 6 Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. 7 Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. 8 Department for Dermatology, Venerology and Allergology, Charité University Medical Centre, Berlin, Germany. 9 Children's Hospital, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 10 Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 11 Division of Allergy, Ospedale Pediatrico Bambino Gesu, Roma, Italy. 12 Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. 13 Allergy Unit, 2nd Paediatric Clinic, University of Athens, Athens, Greece. 14 Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK. 15 Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. 16 Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 17 Department of Pediatric Pulmonology and Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands. 18 Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. 19 Department of Paediatric Pulmonology and Immunology, Charité University Medical Centre, Berlin, Germany. 20 NIHR Southampton Respiratory Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 21 The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
format Article in Journal/Newspaper
author Selby, Anna
Munro, Alasdair
Grimshaw, Kate E
Cornelius, Victoria
Keil, Thomas
Grabenhenrich, Linus
Clausen, Michael
Dubakiene, Ruta
Fiocchi, Alessandro
Kowalski, Marek L
Papadopoulos, Nikolaos G
Reche, Marta
Sigurdardottir, Sigurveig T
Sprikkelman, Aline B
Xepapadaki, Paraskevi
Mills, E N Clare
Beyer, Kirsten
Roberts, Graham
author_facet Selby, Anna
Munro, Alasdair
Grimshaw, Kate E
Cornelius, Victoria
Keil, Thomas
Grabenhenrich, Linus
Clausen, Michael
Dubakiene, Ruta
Fiocchi, Alessandro
Kowalski, Marek L
Papadopoulos, Nikolaos G
Reche, Marta
Sigurdardottir, Sigurveig T
Sprikkelman, Aline B
Xepapadaki, Paraskevi
Mills, E N Clare
Beyer, Kirsten
Roberts, Graham
author_sort Selby, Anna
title Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
title_short Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
title_full Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
title_fullStr Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
title_full_unstemmed Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort.
title_sort prevalence estimates and risk factors for early childhood wheeze across europe: the europrevall birth cohort.
publisher BMJ Publishing Group
publishDate 2019
url http://hdl.handle.net/2336/620781
https://doi.org/10.1136/thoraxjnl-2016-209429
genre Iceland
genre_facet Iceland
op_source Thorax
op_relation https://thorax.bmj.com/content/73/11/1049
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort. 2018, 73(11):1049-1061 Thorax
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doi:10.1136/thoraxjnl-2016-209429
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container_title Thorax
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container_issue 11
container_start_page 1049
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spelling ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620781 2023-05-15T16:51:49+02:00 Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort. Selby, Anna Munro, Alasdair Grimshaw, Kate E Cornelius, Victoria Keil, Thomas Grabenhenrich, Linus Clausen, Michael Dubakiene, Ruta Fiocchi, Alessandro Kowalski, Marek L Papadopoulos, Nikolaos G Reche, Marta Sigurdardottir, Sigurveig T Sprikkelman, Aline B Xepapadaki, Paraskevi Mills, E N Clare Beyer, Kirsten Roberts, Graham 1 Clinical and Experimental Sciences and Human Development and Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, UK. 2 Department of Paediatrics, Royal Hampshire County Hospital, Winchester, UK. 3 Department of Nutrition and Dietetics, Southampton Children's Hospital, Southampton, UK. 4 Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK. 5 Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Berlin, Germany. 6 Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. 7 Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. 8 Department for Dermatology, Venerology and Allergology, Charité University Medical Centre, Berlin, Germany. 9 Children's Hospital, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 10 Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 11 Division of Allergy, Ospedale Pediatrico Bambino Gesu, Roma, Italy. 12 Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. 13 Allergy Unit, 2nd Paediatric Clinic, University of Athens, Athens, Greece. 14 Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK. 15 Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. 16 Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 17 Department of Pediatric Pulmonology and Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands. 18 Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. 19 Department of Paediatric Pulmonology and Immunology, Charité University Medical Centre, Berlin, Germany. 20 NIHR Southampton Respiratory Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 21 The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK. 2019-01 http://hdl.handle.net/2336/620781 https://doi.org/10.1136/thoraxjnl-2016-209429 en eng BMJ Publishing Group https://thorax.bmj.com/content/73/11/1049 Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort. 2018, 73(11):1049-1061 Thorax 1468-3296 29748253 doi:10.1136/thoraxjnl-2016-209429 http://hdl.handle.net/2336/620781 Thorax National Consortium - Landsaðgangur Thorax asthma epidemiology paediatric asthma Öndunarfærasjúkdómar Astmi Leikskólabörn Respiratory Sounds Asthma Child Preschool Article 2019 ftlandspitaliuni https://doi.org/10.1136/thoraxjnl-2016-209429 2022-05-29T08:22:23Z To access publisher's full text version of this article click on the hyperlink below Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. European Commission under the 6th Framework Programme Integrated Approaches to Food Allergy and Allergy Risk Management, a 7th Framework Collaborative Project UK Food Standards Agency Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Thorax 73 11 1049 1061