Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland.

• Published in: Journal of Clinical Microbiology
• Main Authors: Quirk, Sigríður J, Haraldsson, Gunnsteinn, Erlendsdóttir, Helga, Hjálmarsdóttir, Martha Á, van Tonder, Andries J, Hrafnkelsson, Birgir, Sigurdsson, Samuel, Bentley, Stephen D, Haraldsson, Ásgeir, Brueggemann, Angela B, Kristinsson, Karl G
• Other Authors: 1 Univ Iceland, Fac Med, Reykjavik, Iceland Show more 2 Landspitali Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland Show more 3 Univ Iceland, Biomed Ctr, Reykjavik, Iceland Show more 4 Wellcome Sanger Inst, Parasites & Microbes, Hinxton, England Show more 5 Univ Iceland, Dept Math, Reykjavik, Iceland 6 Childrens Hosp Iceland, Reykjavik, Iceland Show more 7 Univ Oxford, Nuffield Dept Med, Oxford, England Show more 8 Imperial Coll London, Dept Med, London, England
• Format: Article in Journal/Newspaper
• Language: English
• Published: American Society for Microbiology 2019
• Subjects: Iceland; Streptococcus pneumoniae; carriage; epidemiology; molecular epidemiology; otitis media; pneumococcus; vaccination; vaccine; Gerlar; Bakteríusjúkdómar; Eyrnabólga; Bólusetningar
• Online Access: http://hdl.handle.net/2336/620777; https://doi.org/10.1128/JCM.01046-18

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from children in Iceland. Pneumococci were collected between 2009 and 2017 from the nasopharynges of healthy children attending 15 day care centers and from the middle ears (MEs) of children with acute otitis media from the greater Reykjavik capital area. Isolates were serotyped and tested for antimicrobial susceptibility. Whole-genome sequencing (WGS) was performed on alternate isolates from 2009 to 2014, and serotypes and multilocus sequence types (STs) were extracted from the WGS data. Two study periods were defined: 2009 to 2011 (PreVac) and 2012 to 2017 (PostVac). The overall nasopharyngeal carriage rate was similar between the two periods (67.3% PreVac and 61.5% PostVac, GlaxoSmithKline Biologicals SA Landspitali University Hospital Research Fund Eimskip University Fund Wellcome Trust John Fell Fund Wellcome core funding