Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
To access publisher's full text version of this article click on the hyperlink below Osteoarthritis has a highly negative impact on quality of life because of the associated pain and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of the hip and the k...
Published in: | Nature Genetics |
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Online Access: | http://hdl.handle.net/2336/620774 https://doi.org/10.1038/s41588-018-0247-0 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620774 2023-05-15T16:49:28+02:00 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. Styrkarsdottir, Unnur Lund, Sigrun H Thorleifsson, Gudmar Zink, Florian Stefansson, Olafur A Sigurdsson, Jon K Juliusson, Kristinn Bjarnadottir, Kristbjörg Sigurbjornsdottir, Sara Jonsson, Stefan Norland, Kristjan Stefansdottir, Lilja Sigurdsson, Asgeir Sveinbjornsson, Gardar Oddsson, Asmundur Bjornsdottir, Gyda Gudmundsson, Reynir L Halldorsson, Gisli H Rafnar, Thorunn Jonsdottir, Ingileif Steingrimsson, Eirikur Norddahl, Gudmundur L Masson, Gisli Sulem, Patrick Jonsson, Helgi Ingvarsson, Thorvaldur Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Stefansson, Kari 1 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. unnur.styrkarsdottir@decode.is. 2 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 3 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 4 Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 5 Department of Immunology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 6 Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 7 Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland. 8 Institution of Health Science, University of Akureyri, Akureyri, Iceland. 9 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 10 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. kstefans@decode.is. 11 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. kstefans@decode.is. 2019-01 http://hdl.handle.net/2336/620774 https://doi.org/10.1038/s41588-018-0247-0 en eng Nature Publishing Group https://www.nature.com/articles/s41588-018-0247-0 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 2018, 50(12):1681-1687 Nat Genet 1546-1718 30374069 doi:10.1038/s41588-018-0247-0 http://hdl.handle.net/2336/620774 Nature genetics Landspitali Access - LSH-aðgangur Nature genetics Slitgigt Gen Genome-Wide Association Study Osteoarthritis Article 2019 ftlandspitaliuni https://doi.org/10.1038/s41588-018-0247-0 2022-05-29T08:22:23Z To access publisher's full text version of this article click on the hyperlink below Osteoarthritis has a highly negative impact on quality of life because of the associated pain and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of the hip and the knee in samples from Iceland and the UK Biobank (including 17,151 hip osteoarthritis patients, 23,877 knee osteoarthritis patients, and more than 562,000 controls). We found 23 independent associations at 22 loci in the additive meta-analyses, of which 16 of the loci were novel: 12 for hip and 4 for knee osteoarthritis. Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10 Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 50 12 1681 1687 |
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Hirsla - Landspítali University Hospital research archive |
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Slitgigt Gen Genome-Wide Association Study Osteoarthritis |
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Slitgigt Gen Genome-Wide Association Study Osteoarthritis Styrkarsdottir, Unnur Lund, Sigrun H Thorleifsson, Gudmar Zink, Florian Stefansson, Olafur A Sigurdsson, Jon K Juliusson, Kristinn Bjarnadottir, Kristbjörg Sigurbjornsdottir, Sara Jonsson, Stefan Norland, Kristjan Stefansdottir, Lilja Sigurdsson, Asgeir Sveinbjornsson, Gardar Oddsson, Asmundur Bjornsdottir, Gyda Gudmundsson, Reynir L Halldorsson, Gisli H Rafnar, Thorunn Jonsdottir, Ingileif Steingrimsson, Eirikur Norddahl, Gudmundur L Masson, Gisli Sulem, Patrick Jonsson, Helgi Ingvarsson, Thorvaldur Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Stefansson, Kari Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
topic_facet |
Slitgigt Gen Genome-Wide Association Study Osteoarthritis |
description |
To access publisher's full text version of this article click on the hyperlink below Osteoarthritis has a highly negative impact on quality of life because of the associated pain and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of the hip and the knee in samples from Iceland and the UK Biobank (including 17,151 hip osteoarthritis patients, 23,877 knee osteoarthritis patients, and more than 562,000 controls). We found 23 independent associations at 22 loci in the additive meta-analyses, of which 16 of the loci were novel: 12 for hip and 4 for knee osteoarthritis. Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10 |
author2 |
1 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. unnur.styrkarsdottir@decode.is. 2 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 3 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 4 Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 5 Department of Immunology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 6 Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 7 Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland. 8 Institution of Health Science, University of Akureyri, Akureyri, Iceland. 9 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 10 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. kstefans@decode.is. 11 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. kstefans@decode.is. |
format |
Article in Journal/Newspaper |
author |
Styrkarsdottir, Unnur Lund, Sigrun H Thorleifsson, Gudmar Zink, Florian Stefansson, Olafur A Sigurdsson, Jon K Juliusson, Kristinn Bjarnadottir, Kristbjörg Sigurbjornsdottir, Sara Jonsson, Stefan Norland, Kristjan Stefansdottir, Lilja Sigurdsson, Asgeir Sveinbjornsson, Gardar Oddsson, Asmundur Bjornsdottir, Gyda Gudmundsson, Reynir L Halldorsson, Gisli H Rafnar, Thorunn Jonsdottir, Ingileif Steingrimsson, Eirikur Norddahl, Gudmundur L Masson, Gisli Sulem, Patrick Jonsson, Helgi Ingvarsson, Thorvaldur Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Stefansson, Kari |
author_facet |
Styrkarsdottir, Unnur Lund, Sigrun H Thorleifsson, Gudmar Zink, Florian Stefansson, Olafur A Sigurdsson, Jon K Juliusson, Kristinn Bjarnadottir, Kristbjörg Sigurbjornsdottir, Sara Jonsson, Stefan Norland, Kristjan Stefansdottir, Lilja Sigurdsson, Asgeir Sveinbjornsson, Gardar Oddsson, Asmundur Bjornsdottir, Gyda Gudmundsson, Reynir L Halldorsson, Gisli H Rafnar, Thorunn Jonsdottir, Ingileif Steingrimsson, Eirikur Norddahl, Gudmundur L Masson, Gisli Sulem, Patrick Jonsson, Helgi Ingvarsson, Thorvaldur Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Stefansson, Kari |
author_sort |
Styrkarsdottir, Unnur |
title |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
title_short |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
title_full |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
title_fullStr |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
title_full_unstemmed |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. |
title_sort |
meta-analysis of icelandic and uk data sets identifies missense variants in smo, il11, col11a1 and 13 more new loci associated with osteoarthritis. |
publisher |
Nature Publishing Group |
publishDate |
2019 |
url |
http://hdl.handle.net/2336/620774 https://doi.org/10.1038/s41588-018-0247-0 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Nature genetics |
op_relation |
https://www.nature.com/articles/s41588-018-0247-0 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 2018, 50(12):1681-1687 Nat Genet 1546-1718 30374069 doi:10.1038/s41588-018-0247-0 http://hdl.handle.net/2336/620774 Nature genetics |
op_rights |
Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1038/s41588-018-0247-0 |
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Nature Genetics |
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50 |
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12 |
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1681 |
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1687 |
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