Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

• Published in: Nature Communications
• Main Authors: Gudmundsson, Julius, Sigurdsson, Jon K, Stefansdottir, Lilja, Agnarsson, Bjarni A, Isaksson, Helgi J, Stefansson, Olafur A, Gudjonsson, Sigurjon A, Gudbjartsson, Daniel F, Masson, Gisli, Frigge, Michael L, Stacey, Simon N, Sulem, Patrick, Halldorsson, Gisli H, Tragante, Vinicius, Holm, Hilma, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Olafsson, Isleifur, Jonsson, Thorvaldur, Jonsson, Eirikur, Barkardottir, Rosa B, Hilmarsson, Rafn, Asselbergs, Folkert W, Geirsson, Gudmundur, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Thorleifsson, Gudmar, Stefansson, Kari
• Other Authors: 1 deCODE genetics/AMGEN, 101, Reykjavik, Iceland. [e-mail]. 2 deCODE genetics/AMGEN, 101, Reykjavik, Iceland. 3 Landspitali-University Hospital, 101, Reykjavik, Iceland. 4 Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 5 School of Engineering and Natural Sciences, University of Iceland, 101, Reykjavik, Iceland. 6 Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, 3584 CX, Utrecht, The Netherlands. 7 The Clinical Laboratory in Mjodd, 109, Reykjavik, Iceland. 8 Department of Clinical Biochemistry, Akureyri Hospital, 600, Akureyri, Iceland. 9 Laboratory of Cell Biology, Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 10 Biomedical Centre, Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 11 Durrer Center for Cardiovascular Research, Netherlands Heart Institute, 3511 EP, Utrecht, The Netherlands. 12 Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, WC1E 6BT, UK. 13 Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, NW1 2DA, UK. 14 deCODE genetics/AMGEN, 101, Reykjavik, Iceland. [e-mail]. 15 Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. [e-mail].
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2018
• Subjects: Blöðruhálskirtill; Genarannsóknir; Gen; Prostatic Hyperplasia; Genome-Wide Association Study; Iceland
• Online Access: http://hdl.handle.net/2336/620766; https://doi.org/10.1038/s41467-018-06920-9

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P < 0.0022). Furthermore, there is a strong genetic correlation, r UCL Hospitals NIHR Biomedical Research Centre