Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome.

• Published in: Human Pathology
• Main Authors: Hemminger, Jessica A, Pearlman, Rachel, Haraldsdottir, Sigurdis, Knight, Deborah, Jonasson, Jon Gunnlaugur, Pritchard, Colin C, Hampel, Heather, Frankel, Wendy L
• Other Authors: 1 Ohio State Univ, Wexner Med Ctr, Dept Pathol, Columbus, OH 43210 USA Show more 2 Ohio State Univ, Wexner Med Ctr, Dept Internal Med, Div Human Genet, Columbus, OH 43210 USA Show more 3 Stanford Univ, Med Ctr, Dept Med Oncol, Stanford, CA 94305 USA Show more 4 Landspitali Univ Hosp, IS-101 Reykjavik, Iceland Show more 5 Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
• Format: Article in Journal/Newspaper
• Language: English
• Published: W B SAUNDERS CO-ELSEVIER INC 2018
• Subjects: Biallelic mutations; Double somatic mutations; Lynch syndrome; Lynch-like syndrome; MMR deficiency; Ristilkrabbamein; Vefjafræði; Colorectal Neoplasms; Adenocarcinoma; Lynch; Iceland
• Online Access: http://hdl.handle.net/2336/620711; https://doi.org/10.1016/j.humpath.2018.04.017

To access publisher's full text version of this article click on the hyperlink below Lynch syndrome (LS) is the most common form of hereditary colon cancer. Germline mutations in the mismatch-repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2, followed by a second hit to the remaining allele...