Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits
To access publisher's full text version of this article click on the hyperlink below Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferr...
Published in: | Journal of Drug Delivery Science and Technology |
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Online Access: | http://hdl.handle.net/2336/620659 https://doi.org/10.1016/j.jddst.2018.04.007 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620659 2023-05-15T16:47:18+02:00 Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits Johannsdottir, Sunna Jansook, Phatsawee Stefansson, Einar Kristinsdottir, Iris Myrdal Fulop, Zoltan Asgrimsdottir, Gudrun Marta Thorsteindsottir, Margret Eiriksson, Finnur Freyr Loftsson, Thorsteinn 1 Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland 2 Oculis Ehf, Reykjavik, Iceland Show more 3 Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok, Thailand Show more 4 Landspitali Univ Hosp, Reykjavik, Iceland 2018 http://hdl.handle.net/2336/620659 https://doi.org/10.1016/j.jddst.2018.04.007 en eng Elsevier Science http://linkinghub.elsevier.com/retrieve/pii/S1773224718301813 Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits 2018, 45:449 Journal of Drug Delivery Science and Technology 17732247 doi:10.1016/j.jddst.2018.04.007 http://hdl.handle.net/2336/620659 Journal of Drug Delivery Science and Technology Archived with thanks to Journal of Drug Delivery Science and Technology National Consortium - Landsaðgangur Augnlækningar Augnbotnar Lyf Lyfjagjöf Ophthalmic Solutions Dexamethasone Pharmacokinetics Posterior Eye Segment Eye Article 2018 ftlandspitaliuni https://doi.org/10.1016/j.jddst.2018.04.007 2022-05-29T08:22:22Z To access publisher's full text version of this article click on the hyperlink below Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug delivery system provides an option, which would enhance the drug permeability across the barriers and achieve the desired drug level in the targeted tissue. Areas covered: This review highlights the barrier to the posterior segment of the eye via topical administration. The up-to-date development of lipid nanoparticles, liposomes, emulsions, spanlastics, micelles, polymeric nanoparticles, layered double hydroxides (LDH), dendrimers, cyclodextrins(CDs), and prodrugs are summarized. Moreover, nanocarriers currently in clinical trials for posterior segment diseases have been discussed. Expert opinion: Topical nanoparticle-based drug delivery systems have demonstrated significant progress. An ideal formulation should prolong retention time on the surface, enhance drug permeability through the ocular tissues, and efficiently deliver drugs to the targeted site. To design the rational targeting nanoparticle-based drug delivery system, a better understanding of the distribution of transporters and receptors on the eye is required. Ultimately, there is an urgent need to develop targeting hybrid drug delivery systems with the combination of the advantages of several nanocarriers. University of Iceland Research Fund, University of Iceland Reykjavik and Oculis ehf, Reykjavik, Iceland Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Journal of Drug Delivery Science and Technology 45 449 454 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Augnlækningar Augnbotnar Lyf Lyfjagjöf Ophthalmic Solutions Dexamethasone Pharmacokinetics Posterior Eye Segment Eye |
spellingShingle |
Augnlækningar Augnbotnar Lyf Lyfjagjöf Ophthalmic Solutions Dexamethasone Pharmacokinetics Posterior Eye Segment Eye Johannsdottir, Sunna Jansook, Phatsawee Stefansson, Einar Kristinsdottir, Iris Myrdal Fulop, Zoltan Asgrimsdottir, Gudrun Marta Thorsteindsottir, Margret Eiriksson, Finnur Freyr Loftsson, Thorsteinn Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
topic_facet |
Augnlækningar Augnbotnar Lyf Lyfjagjöf Ophthalmic Solutions Dexamethasone Pharmacokinetics Posterior Eye Segment Eye |
description |
To access publisher's full text version of this article click on the hyperlink below Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug delivery system provides an option, which would enhance the drug permeability across the barriers and achieve the desired drug level in the targeted tissue. Areas covered: This review highlights the barrier to the posterior segment of the eye via topical administration. The up-to-date development of lipid nanoparticles, liposomes, emulsions, spanlastics, micelles, polymeric nanoparticles, layered double hydroxides (LDH), dendrimers, cyclodextrins(CDs), and prodrugs are summarized. Moreover, nanocarriers currently in clinical trials for posterior segment diseases have been discussed. Expert opinion: Topical nanoparticle-based drug delivery systems have demonstrated significant progress. An ideal formulation should prolong retention time on the surface, enhance drug permeability through the ocular tissues, and efficiently deliver drugs to the targeted site. To design the rational targeting nanoparticle-based drug delivery system, a better understanding of the distribution of transporters and receptors on the eye is required. Ultimately, there is an urgent need to develop targeting hybrid drug delivery systems with the combination of the advantages of several nanocarriers. University of Iceland Research Fund, University of Iceland Reykjavik and Oculis ehf, Reykjavik, Iceland |
author2 |
1 Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland 2 Oculis Ehf, Reykjavik, Iceland Show more 3 Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok, Thailand Show more 4 Landspitali Univ Hosp, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Johannsdottir, Sunna Jansook, Phatsawee Stefansson, Einar Kristinsdottir, Iris Myrdal Fulop, Zoltan Asgrimsdottir, Gudrun Marta Thorsteindsottir, Margret Eiriksson, Finnur Freyr Loftsson, Thorsteinn |
author_facet |
Johannsdottir, Sunna Jansook, Phatsawee Stefansson, Einar Kristinsdottir, Iris Myrdal Fulop, Zoltan Asgrimsdottir, Gudrun Marta Thorsteindsottir, Margret Eiriksson, Finnur Freyr Loftsson, Thorsteinn |
author_sort |
Johannsdottir, Sunna |
title |
Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
title_short |
Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
title_full |
Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
title_fullStr |
Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
title_full_unstemmed |
Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
title_sort |
topical drug delivery to the posterior segment of the eye: dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits |
publisher |
Elsevier Science |
publishDate |
2018 |
url |
http://hdl.handle.net/2336/620659 https://doi.org/10.1016/j.jddst.2018.04.007 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://linkinghub.elsevier.com/retrieve/pii/S1773224718301813 Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits 2018, 45:449 Journal of Drug Delivery Science and Technology 17732247 doi:10.1016/j.jddst.2018.04.007 http://hdl.handle.net/2336/620659 Journal of Drug Delivery Science and Technology |
op_rights |
Archived with thanks to Journal of Drug Delivery Science and Technology National Consortium - Landsaðgangur |
op_doi |
https://doi.org/10.1016/j.jddst.2018.04.007 |
container_title |
Journal of Drug Delivery Science and Technology |
container_volume |
45 |
container_start_page |
449 |
op_container_end_page |
454 |
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1766037390774763520 |