Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits

• Published in: Journal of Drug Delivery Science and Technology
• Main Authors: Johannsdottir, Sunna, Jansook, Phatsawee, Stefansson, Einar, Kristinsdottir, Iris Myrdal, Fulop, Zoltan, Asgrimsdottir, Gudrun Marta, Thorsteindsottir, Margret, Eiriksson, Finnur Freyr, Loftsson, Thorsteinn
• Other Authors: 1 Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland 2 Oculis Ehf, Reykjavik, Iceland Show more 3 Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok, Thailand Show more 4 Landspitali Univ Hosp, Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier Science 2018
• Subjects: Augnlækningar; Augnbotnar; Lyf; Lyfjagjöf; Ophthalmic Solutions; Dexamethasone; Pharmacokinetics; Posterior Eye Segment; Eye; Iceland
• Online Access: http://hdl.handle.net/2336/620659; https://doi.org/10.1016/j.jddst.2018.04.007

To access publisher's full text version of this article click on the hyperlink below Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug delivery system provides an option, which would enhance the drug permeability across the barriers and achieve the desired drug level in the targeted tissue. Areas covered: This review highlights the barrier to the posterior segment of the eye via topical administration. The up-to-date development of lipid nanoparticles, liposomes, emulsions, spanlastics, micelles, polymeric nanoparticles, layered double hydroxides (LDH), dendrimers, cyclodextrins(CDs), and prodrugs are summarized. Moreover, nanocarriers currently in clinical trials for posterior segment diseases have been discussed. Expert opinion: Topical nanoparticle-based drug delivery systems have demonstrated significant progress. An ideal formulation should prolong retention time on the surface, enhance drug permeability through the ocular tissues, and efficiently deliver drugs to the targeted site. To design the rational targeting nanoparticle-based drug delivery system, a better understanding of the distribution of transporters and receptors on the eye is required. Ultimately, there is an urgent need to develop targeting hybrid drug delivery systems with the combination of the advantages of several nanocarriers. University of Iceland Research Fund, University of Iceland Reykjavik and Oculis ehf, Reykjavik, Iceland