Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine.
To access publisher's full text version of this article click on the hyperlink below Acute otitis media (AOM) nonresponsive to antibiotics is most commonly caused by antibiotic-resistant Streptococcus pneumoniae and Haemophilus influenzae. A strategy for treating these infections with parentera...
Published in: | Pediatric Infectious Disease Journal |
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Language: | English |
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Lippincott Williams & Wilkins
2018
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Online Access: | http://hdl.handle.net/2336/620588 https://doi.org/10.1097/INF.0000000000001870 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620588 2023-05-15T16:47:43+02:00 Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. Eythorsson, Elias Hrafnkelsson, Birgir Erlendsdóttir, Helga Gudmundsson, Sigmar Atli Kristinsson, Karl G Haraldsson, Ásgeir 1 Univ Iceland, Fac Med, Reykjavik, Iceland Show more 2 Univ Iceland, Fac Phys Sci, Dept Math, Reykjavik, Iceland Show more 3 Landspitali Univ Hosp, Reykjavik, Iceland Show more 4 Landspitali Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland Show more 5 Landspitali Univ Hosp, Childrens Hosp Iceland, IS-101 Reykjavik, Iceland 2018 http://hdl.handle.net/2336/620588 https://doi.org/10.1097/INF.0000000000001870 en eng Lippincott Williams & Wilkins https://journals.lww.com/pidj/Fulltext/2018/04000/Decreased_Acute_Otitis_Media_With_Treatment.18.aspx Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. 2018, 37 (4):361-366 Pediatr. Infect. Dis. J. 1532-0987 29278616 doi:10.1097/INF.0000000000001870 http://hdl.handle.net/2336/620588 The Pediatric infectious disease journal Archived with thanks to The Pediatric infectious disease journal Landspitali Access - LSH-aðgangur Eyrnabólga Bólusetningar Lyfjaónæmi Bakteríusjúkdómar NAF12 PED12 BAC12 Otitis Media Streptococcus pneumoniae Pneumococcal Vaccines Drug Resistance Article 2018 ftlandspitaliuni https://doi.org/10.1097/INF.0000000000001870 2022-05-29T08:22:21Z To access publisher's full text version of this article click on the hyperlink below Acute otitis media (AOM) nonresponsive to antibiotics is most commonly caused by antibiotic-resistant Streptococcus pneumoniae and Haemophilus influenzae. A strategy for treating these infections with parenteral ceftriaxone was adopted at the Children's Hospital Iceland. The 10-valent pneumococcal H. influenzae protein D-conjugate vaccine was introduced into the vaccination program in Iceland in 2011. The aim was to study its effect on the incidence of AOM with treatment failure. This retrospective observational study included children who visited the Children's Hospital Iceland because of AOM or received ceftriaxone, regardless of indication from 2008-2015. Incidence rate was calculated for prevaccine (2008-2011) and postvaccine (2012-2015) periods using person-years at risk within the hospital's referral region. Incidence rate ratio of ceftriaxone treatment episodes of AOM was calculated using the Mantel-Haenzel method adjusting for age. Incidence risk ratio of ceftriaxone treatment if presenting to the hospital with AOM was calculated to adjust for rate of AOM visits. Visits for AOM decreased from 47.5 to 33.9 visits per 1000 person-years, incidence rate ratio (IRR) 0.86 (95% confidence interval [CI]: 0.81-0.91), P < 0.001. Fewer AOM episodes were treated with ceftriaxone, decreasing from 6.49 to 2.96 treatment episodes per 1000 person-years, with an overall Mantel-Haenzel adjusted IRR 0.45 (95% CI: 0.37-0.54; P < 0.001). This remained significant after adjusting for the decrease in AOM visits, IRR 0.53 (95% CI: 0.44-0.63; P < 0.001). Visits for AOM and ceftriaxone use decreased significantly after H. influenzae protein D-conjugate vaccine introduction. The observed decrease in ceftriaxone use is presumed to represent a decline in AOM with treatment failure, secondary to a decrease in resistant infections. GlaxoSmithKline Biologicals SA Landspitali University Hospital Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Pediatric Infectious Disease Journal 37 4 361 366 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Eyrnabólga Bólusetningar Lyfjaónæmi Bakteríusjúkdómar NAF12 PED12 BAC12 Otitis Media Streptococcus pneumoniae Pneumococcal Vaccines Drug Resistance |
spellingShingle |
Eyrnabólga Bólusetningar Lyfjaónæmi Bakteríusjúkdómar NAF12 PED12 BAC12 Otitis Media Streptococcus pneumoniae Pneumococcal Vaccines Drug Resistance Eythorsson, Elias Hrafnkelsson, Birgir Erlendsdóttir, Helga Gudmundsson, Sigmar Atli Kristinsson, Karl G Haraldsson, Ásgeir Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
topic_facet |
Eyrnabólga Bólusetningar Lyfjaónæmi Bakteríusjúkdómar NAF12 PED12 BAC12 Otitis Media Streptococcus pneumoniae Pneumococcal Vaccines Drug Resistance |
description |
To access publisher's full text version of this article click on the hyperlink below Acute otitis media (AOM) nonresponsive to antibiotics is most commonly caused by antibiotic-resistant Streptococcus pneumoniae and Haemophilus influenzae. A strategy for treating these infections with parenteral ceftriaxone was adopted at the Children's Hospital Iceland. The 10-valent pneumococcal H. influenzae protein D-conjugate vaccine was introduced into the vaccination program in Iceland in 2011. The aim was to study its effect on the incidence of AOM with treatment failure. This retrospective observational study included children who visited the Children's Hospital Iceland because of AOM or received ceftriaxone, regardless of indication from 2008-2015. Incidence rate was calculated for prevaccine (2008-2011) and postvaccine (2012-2015) periods using person-years at risk within the hospital's referral region. Incidence rate ratio of ceftriaxone treatment episodes of AOM was calculated using the Mantel-Haenzel method adjusting for age. Incidence risk ratio of ceftriaxone treatment if presenting to the hospital with AOM was calculated to adjust for rate of AOM visits. Visits for AOM decreased from 47.5 to 33.9 visits per 1000 person-years, incidence rate ratio (IRR) 0.86 (95% confidence interval [CI]: 0.81-0.91), P < 0.001. Fewer AOM episodes were treated with ceftriaxone, decreasing from 6.49 to 2.96 treatment episodes per 1000 person-years, with an overall Mantel-Haenzel adjusted IRR 0.45 (95% CI: 0.37-0.54; P < 0.001). This remained significant after adjusting for the decrease in AOM visits, IRR 0.53 (95% CI: 0.44-0.63; P < 0.001). Visits for AOM and ceftriaxone use decreased significantly after H. influenzae protein D-conjugate vaccine introduction. The observed decrease in ceftriaxone use is presumed to represent a decline in AOM with treatment failure, secondary to a decrease in resistant infections. GlaxoSmithKline Biologicals SA Landspitali University Hospital Research Fund |
author2 |
1 Univ Iceland, Fac Med, Reykjavik, Iceland Show more 2 Univ Iceland, Fac Phys Sci, Dept Math, Reykjavik, Iceland Show more 3 Landspitali Univ Hosp, Reykjavik, Iceland Show more 4 Landspitali Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland Show more 5 Landspitali Univ Hosp, Childrens Hosp Iceland, IS-101 Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Eythorsson, Elias Hrafnkelsson, Birgir Erlendsdóttir, Helga Gudmundsson, Sigmar Atli Kristinsson, Karl G Haraldsson, Ásgeir |
author_facet |
Eythorsson, Elias Hrafnkelsson, Birgir Erlendsdóttir, Helga Gudmundsson, Sigmar Atli Kristinsson, Karl G Haraldsson, Ásgeir |
author_sort |
Eythorsson, Elias |
title |
Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
title_short |
Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
title_full |
Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
title_fullStr |
Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
title_full_unstemmed |
Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. |
title_sort |
decreased acute otitis media with treatment failure after introduction of the ten-valent pneumococcal haemophilus influenzae protein d conjugate vaccine. |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2018 |
url |
http://hdl.handle.net/2336/620588 https://doi.org/10.1097/INF.0000000000001870 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://journals.lww.com/pidj/Fulltext/2018/04000/Decreased_Acute_Otitis_Media_With_Treatment.18.aspx Decreased Acute Otitis Media With Treatment Failure After Introduction of the Ten-valent Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine. 2018, 37 (4):361-366 Pediatr. Infect. Dis. J. 1532-0987 29278616 doi:10.1097/INF.0000000000001870 http://hdl.handle.net/2336/620588 The Pediatric infectious disease journal |
op_rights |
Archived with thanks to The Pediatric infectious disease journal Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1097/INF.0000000000001870 |
container_title |
Pediatric Infectious Disease Journal |
container_volume |
37 |
container_issue |
4 |
container_start_page |
361 |
op_container_end_page |
366 |
_version_ |
1766037816233426944 |