Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014.
To access publisher's full text version of this article click on the hyperlink below An increasing number of elderly patients are diagnosed with non-small cell lung cancer (NSCLC). We compared the surgical resection rate, operability and survival in this age group (≥75 years) to younger patient...
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Oxford University Press
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Online Access: | http://hdl.handle.net/2336/620336 https://doi.org/10.1093/icvts/ivw415 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620336 2023-05-15T16:47:43+02:00 Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. Baldvinsson, Kristjan Oskarsdottir, Gudrun Nina Orrason, Andri Wilberg Halldorsson, Hannes Thorsteinsson, Hunbogi Sigurdsson, Martin Ingi Jonsson, Steinn Gudbjartsson, Tomas 1 Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland Show the Organization-Enhanced name(s) 2 Univ Iceland, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) 3 Brigham & Womens Hosp, Dept Anesthesiol, 75 Francis St, Boston, MA 02115 USA 4 Landspitali Univ, Dept Pulmonol, Reykjavik, Iceland 2017 http://hdl.handle.net/2336/620336 https://doi.org/10.1093/icvts/ivw415 en eng Oxford University Press https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/icvts/24/5/10.1093_icvts_ivw415/4/ivw415.pdf?Expires=1509558501&Signature=MAuTJh1v4Cd59g3DtQDnclp0uapfvuZ7lEcwFU7q5VsriovLPL7xkX53AXnqls~tSvN0Y9uMuxDDpHN9lMjBP~kICY7Oen6rKdaZgWFhn7OG8PqOBCjb0L9lsE-mSvYxUVjLiaMM2L2wHnqIGo0let2FaItXCEFkbV8ORg1nAZXDtXxoRzqiJVMjr2rwEGJhqGo8BkPaMk7GJloafP9bTx5awfuEsYGJLJWM-hSKJCyBrWBS51FmHWRy1zCGv5WUKlo4Po~b6QjgmTzS4VSukJbph1RhRHuWV4XbOFaT2bkCR1N~kZjTuITWJqQ10spddpZHckJzR8GIOeI2qv78rg__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. 2017, 24 (5):733-739 Interact Cardiovasc Thorac Surg 1569-9285 28329255 doi:10.1093/icvts/ivw415 http://hdl.handle.net/2336/620336 Interactive cardiovascular and thoracic surgery Archived with thanks to Interactive cardiovascular and thoracic surgery Landspitali Access - LSH-aðgangur Lungnakrabbamein Aldraðir Skurðlækningar PAD12 TAS12 Aged 80 and over Carcinoma Non-Small-Cell Lung Female Follow-Up Studies Forecasting Humans Iceland Incidence Lung Neoplasms Male Neoplasm Staging Pneumonectomy Population Surveillance Retrospective Studies Survival Rate Treatment Outcome Article 2017 ftlandspitaliuni https://doi.org/10.1093/icvts/ivw415 2022-05-29T08:22:16Z To access publisher's full text version of this article click on the hyperlink below An increasing number of elderly patients are diagnosed with non-small cell lung cancer (NSCLC). We compared the surgical resection rate, operability and survival in this age group (≥75 years) to younger patients using centralized databases in Iceland. The study population comprised all patients diagnosed with NSCLC in Iceland from 1991 to 2014. A total of 140 elderly patients (≥75 years) with NSCLC underwent pulmonary resection and were compared with 550 surgically resected patients less than 75 years, with respect to resection rate, short and long-term survival and complications of surgery. Reasons for exclusion from surgery were registered for elderly surgical candidates (stages IA-IIB). Surgical resection rate in the elderly group was 18% compared to 32% in the younger age group ( P < 0.001). The most frequent reasons for not operating on elderly patients in stages IA-IIB were poor pulmonary function (58%), heart disease (17%) or multiple comorbidities (17%). The rate of major complications following surgery was comparable in the elderly versus the younger age group, 13 vs 11%, respectively ( P = 0.578). The same was true for 30 day mortality (2 vs 1%, P = 0.397). Five-year overall survival was 40% vs 44% ( P = 0.019) and cancer-specific survival 51% vs 50% ( P = 0.802). Elderly patients with resectable NSCLC according to stage are frequently excluded from surgery due to comorbid conditions. Although the operated patients may represent a selected group, their favourable 30-day and long-term survival indicate that more elderly patients with NSCLC could be operated on. Landspitali University Research Fund RANNIS, The Icelandic center for Research Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Interactive CardioVascular and Thoracic Surgery 24 5 733 739 |
institution |
Open Polar |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Lungnakrabbamein Aldraðir Skurðlækningar PAD12 TAS12 Aged 80 and over Carcinoma Non-Small-Cell Lung Female Follow-Up Studies Forecasting Humans Iceland Incidence Lung Neoplasms Male Neoplasm Staging Pneumonectomy Population Surveillance Retrospective Studies Survival Rate Treatment Outcome |
spellingShingle |
Lungnakrabbamein Aldraðir Skurðlækningar PAD12 TAS12 Aged 80 and over Carcinoma Non-Small-Cell Lung Female Follow-Up Studies Forecasting Humans Iceland Incidence Lung Neoplasms Male Neoplasm Staging Pneumonectomy Population Surveillance Retrospective Studies Survival Rate Treatment Outcome Baldvinsson, Kristjan Oskarsdottir, Gudrun Nina Orrason, Andri Wilberg Halldorsson, Hannes Thorsteinsson, Hunbogi Sigurdsson, Martin Ingi Jonsson, Steinn Gudbjartsson, Tomas Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
topic_facet |
Lungnakrabbamein Aldraðir Skurðlækningar PAD12 TAS12 Aged 80 and over Carcinoma Non-Small-Cell Lung Female Follow-Up Studies Forecasting Humans Iceland Incidence Lung Neoplasms Male Neoplasm Staging Pneumonectomy Population Surveillance Retrospective Studies Survival Rate Treatment Outcome |
description |
To access publisher's full text version of this article click on the hyperlink below An increasing number of elderly patients are diagnosed with non-small cell lung cancer (NSCLC). We compared the surgical resection rate, operability and survival in this age group (≥75 years) to younger patients using centralized databases in Iceland. The study population comprised all patients diagnosed with NSCLC in Iceland from 1991 to 2014. A total of 140 elderly patients (≥75 years) with NSCLC underwent pulmonary resection and were compared with 550 surgically resected patients less than 75 years, with respect to resection rate, short and long-term survival and complications of surgery. Reasons for exclusion from surgery were registered for elderly surgical candidates (stages IA-IIB). Surgical resection rate in the elderly group was 18% compared to 32% in the younger age group ( P < 0.001). The most frequent reasons for not operating on elderly patients in stages IA-IIB were poor pulmonary function (58%), heart disease (17%) or multiple comorbidities (17%). The rate of major complications following surgery was comparable in the elderly versus the younger age group, 13 vs 11%, respectively ( P = 0.578). The same was true for 30 day mortality (2 vs 1%, P = 0.397). Five-year overall survival was 40% vs 44% ( P = 0.019) and cancer-specific survival 51% vs 50% ( P = 0.802). Elderly patients with resectable NSCLC according to stage are frequently excluded from surgery due to comorbid conditions. Although the operated patients may represent a selected group, their favourable 30-day and long-term survival indicate that more elderly patients with NSCLC could be operated on. Landspitali University Research Fund RANNIS, The Icelandic center for Research |
author2 |
1 Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland Show the Organization-Enhanced name(s) 2 Univ Iceland, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) 3 Brigham & Womens Hosp, Dept Anesthesiol, 75 Francis St, Boston, MA 02115 USA 4 Landspitali Univ, Dept Pulmonol, Reykjavik, Iceland |
format |
Article in Journal/Newspaper |
author |
Baldvinsson, Kristjan Oskarsdottir, Gudrun Nina Orrason, Andri Wilberg Halldorsson, Hannes Thorsteinsson, Hunbogi Sigurdsson, Martin Ingi Jonsson, Steinn Gudbjartsson, Tomas |
author_facet |
Baldvinsson, Kristjan Oskarsdottir, Gudrun Nina Orrason, Andri Wilberg Halldorsson, Hannes Thorsteinsson, Hunbogi Sigurdsson, Martin Ingi Jonsson, Steinn Gudbjartsson, Tomas |
author_sort |
Baldvinsson, Kristjan |
title |
Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
title_short |
Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
title_full |
Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
title_fullStr |
Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
title_full_unstemmed |
Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. |
title_sort |
resection rate and operability of elderly patients with non-small cell lung cancer: nationwide study from 1991 to 2014. |
publisher |
Oxford University Press |
publishDate |
2017 |
url |
http://hdl.handle.net/2336/620336 https://doi.org/10.1093/icvts/ivw415 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/icvts/24/5/10.1093_icvts_ivw415/4/ivw415.pdf?Expires=1509558501&Signature=MAuTJh1v4Cd59g3DtQDnclp0uapfvuZ7lEcwFU7q5VsriovLPL7xkX53AXnqls~tSvN0Y9uMuxDDpHN9lMjBP~kICY7Oen6rKdaZgWFhn7OG8PqOBCjb0L9lsE-mSvYxUVjLiaMM2L2wHnqIGo0let2FaItXCEFkbV8ORg1nAZXDtXxoRzqiJVMjr2rwEGJhqGo8BkPaMk7GJloafP9bTx5awfuEsYGJLJWM-hSKJCyBrWBS51FmHWRy1zCGv5WUKlo4Po~b6QjgmTzS4VSukJbph1RhRHuWV4XbOFaT2bkCR1N~kZjTuITWJqQ10spddpZHckJzR8GIOeI2qv78rg__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014. 2017, 24 (5):733-739 Interact Cardiovasc Thorac Surg 1569-9285 28329255 doi:10.1093/icvts/ivw415 http://hdl.handle.net/2336/620336 Interactive cardiovascular and thoracic surgery |
op_rights |
Archived with thanks to Interactive cardiovascular and thoracic surgery Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1093/icvts/ivw415 |
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Interactive CardioVascular and Thoracic Surgery |
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24 |
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5 |
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733 |
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739 |
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