Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later.

• Published in: Journal of the American Heart Association
• Main Authors: Hrolfsdottir, Laufey, Halldorsson, Thorhallur I, Rytter, Dorte, Bech, Bodil Hammer, Birgisdottir, Bryndis E, Gunnarsdottir, Ingibjorg, Granström, Charlotta, Henriksen, Tine Brink, Olsen, Sjurdur F, Maslova, Ekaterina
• Other Authors: 1 Landspitali Univ Hosp, Unit Nutr Res, Reykjavik, Iceland Show the Organization-Enhanced name(s) 2 Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland 3 Statens Serum Inst, Dept Epidemiol Res, Ctr Fetal Programming, Copenhagen, Denmark Show the Organization-Enhanced name(s) 4 Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark Show the Organization-Enhanced name(s) 5 Aarhus Univ Hosp, Dept Pediat, Perinatal Epidemiol Res Unit, Skejby, Denmark Show the Organization-Enhanced name(s) 6 Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA Show the Organization-Enhanced name(s) 7 Imperial Coll, Dept Primary Care & Publ Hlth, London, England 8 Danish Diabet Acad, Odense, Denmark
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2017
• Subjects: Meðganga; Mataræði; Blóðþrýstingur; Börn; Prótín; NUR12; Prenatal Nutritional Physiological Phenomena; Blood Pressure; Adult Children; Dietary Proteins; Iceland
• Online Access: http://hdl.handle.net/2336/620277; https://doi.org/10.1161/JAHA.117.005808

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files Results from 2 cohort studies in Scotland established in the 1940s and 1950s (Aberdeen and Motherwell) suggested that a high protein diet during pregnancy might adversely influence offspring blood pressure at adult age. Our objective was to examine this association in the Danish Fetal Origins Cohort (DaFO88). This was a prospective birth cohort of 965 women who gave birth in 1988-1989 in Aarhus, Denmark, and whose offspring (n=434) participated in a clinical examination ≈20 years later. Macronutrient intake was assessed in gestational week 30. Multivariable adjusted linear regression was used to examine the relation between higher maternal protein intake, at the expense of carbohydrates, and offspring blood pressure (isocaloric substitution). Main analyses were adjusted for mother's age during pregnancy, prepregnancy body mass index, parity, smoking during pregnancy, educational level, and offspring's sex. The mean total energy intake was 8.7 MJ/day (SD 2.3 MJ/day). The mean energy from carbohydrate, fat, and protein intake was 51, 31, and 16 of total energy, respectively. The results showed that after adjustment, higher maternal protein intake was associated with slightly higher offspring diastolic blood pressure (highest compared with the lowest quintile of protein intake: ∆=2.4 mm Hg; 95% CI 0.4-4.4; P=0.03 for trend). Similar differences, although not significant, were found for systolic blood pressure (∆=2.6 mm Hg; 95% CI -0.0 to 5.3; P=0.08 for trend). Higher maternal dietary protein intake at the expense of carbohydrates was associated with a modest increase in offspring blood pressure in young adulthood. Danish Council for Strategic Research University of Iceland