Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial.

• Published in: Acta Dermato Venereologica
• Main Authors: Thorleifsdottir, Ragna Hlin, Sigurdardottir, Sigrun Laufey, Sigurgeirsson, Bardur, Olafsson, Jón Hjaltalin, Sigurdsson, Martin Ingi, Petersen, Hannes, Gudjonsson, Johann Eli, Johnston, Andrew, Valdimarsson, Helgi
• Other Authors: 1 Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) 2 Uppsala Univ, Dept Med Sci, Dermatol, Uppsala, Sweden 3 Landspitali Natl Univ Hosp Iceland, Dept Immunol, Reykjavik, Iceland 4 Landspitali Natl Univ Hosp Iceland, Dept Anesthesiol & Crit Care, Reykjavik, Iceland 5 Landspitali Natl Univ Hosp Iceland, Dept Otolaryngol Head & Neck Surg, Reykjavik, Iceland Show the Organization-Enhanced name(s) 6 Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI USA
• Format: Article in Journal/Newspaper
• Language: English
• Published: Acta Dermato-Venereologica 2017
• Subjects: Sóríasis; Hálskirtlar; AAI12; AAA12; OTO12; Adult; Cost of Illness; Disability Evaluation; Female; Humans; Iceland; Male; Middle Aged; Patient Reported Outcome Measures; Psoriasis; Quality of Life; Remission Induction; Severity of Illness Index; Time Factors; Tonsillectomy; Treatment Outcome; Smella
• Online Access: http://hdl.handle.net/2336/620183; https://doi.org/10.2340/00015555-2562

Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Psoriasis is a chronic inflammatory skin disease with profound effects on patients' health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis. Icelandic Research Fund Landspitali University Hospital Research Fund NIH National Psoriasis Foundation USA Babcock Memorial Trust A. Alfred Taubman Medical Research Institute as the Kenneth and Frances Eisenberg Emerging Scholar Award Doris Duke Charitable Foundation