Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma.
Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn We studied the rate of incidental detection of lung carcinomas and its effect on long-term survival in a nationwide cohort of patients operated for nonsmall cell lung cancer (NSCLC). All patients operated for NSCLC...
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European Respiratory Society
2017
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Online Access: | http://hdl.handle.net/2336/620176 https://doi.org/10.1183/23120541.00106-2016 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620176 2023-05-15T16:51:49+02:00 Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. Orrason, Andri W Sigurdsson, Martin I Baldvinsson, Kristjan Thorsteinsson, Hunbogi Jonsson, Steinn Gudbjartsson, Tomas 1 Dept of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland. 2 Dept of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA. 3 Dept of Pulmonology, Landspitali University Hospital, Reykjavik, Iceland. 4 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2017 http://hdl.handle.net/2336/620176 https://doi.org/10.1183/23120541.00106-2016 en eng European Respiratory Society https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406653/pdf/00106-2016.pdf Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. 2017, 3 (2) ERJ Open Res 28462235 doi:10.1183/23120541.00106-2016 http://hdl.handle.net/2336/620176 ERJ open research Archived with thanks to ERJ open research Open Access - Opinn aðgangur Lungnakrabbamein Sneiðmyndatökur Sjúkdómsgreiningar Lífslíkur TAS12 PAD12 Lung Neoplasms Incidental Findings Tomography X-Ray Computed Survival Article 2017 ftlandspitaliuni https://doi.org/10.1183/23120541.00106-2016 2022-05-29T08:22:15Z Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn We studied the rate of incidental detection of lung carcinomas and its effect on long-term survival in a nationwide cohort of patients operated for nonsmall cell lung cancer (NSCLC). All patients operated for NSCLC in Iceland during 1991-2010 were included. Demographic and clinicopathological features were compared in patients diagnosed incidentally using chest radiography or computed tomography (CT), and in those with symptomatic presentation. Multivariate analysis was used to evaluate prognostic factors. Out of 508 patients, 174 (34%) were diagnosed incidentally; in 26% of cases by chest radiography and in 8% by CT. The CT-detected tumours were significantly smaller than symptomatic tumours, diagnosed at earlier TNM (tumour, node and metastasis) stages and more often of adenocarcinoma histology. 5-year cancer-specific survival for symptomatic versus incidentally diagnosed patients detected by chest radiography and CT was 41%, 57% and 68%, respectively (p=0.003). After adjusting for stage, the hazard ratio (HR) for NSCLC mortality was significantly lower for incidental diagnosis by CT (HR 0.55, 95% CI 0.31‒0.98; p=0.04) compared to incidental diagnosis by chest radiography (HR 0.95, 95% CI 0.70‒1.27; p=0.71) or symptomatic diagnosis (HR 1.0). One-third of surgically treated NSCLCs were detected incidentally, with an increasing rate of incidental CT diagnosis. NSCLC patients diagnosed incidentally by CT appear to have better survival than those diagnosed incidentally by chest radiography, and particularly those who present with symptoms. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Smella ENVELOPE(29.443,29.443,69.896,69.896) TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) ERJ Open Research 3 2 00106-2016 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Lungnakrabbamein Sneiðmyndatökur Sjúkdómsgreiningar Lífslíkur TAS12 PAD12 Lung Neoplasms Incidental Findings Tomography X-Ray Computed Survival |
spellingShingle |
Lungnakrabbamein Sneiðmyndatökur Sjúkdómsgreiningar Lífslíkur TAS12 PAD12 Lung Neoplasms Incidental Findings Tomography X-Ray Computed Survival Orrason, Andri W Sigurdsson, Martin I Baldvinsson, Kristjan Thorsteinsson, Hunbogi Jonsson, Steinn Gudbjartsson, Tomas Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
topic_facet |
Lungnakrabbamein Sneiðmyndatökur Sjúkdómsgreiningar Lífslíkur TAS12 PAD12 Lung Neoplasms Incidental Findings Tomography X-Ray Computed Survival |
description |
Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn We studied the rate of incidental detection of lung carcinomas and its effect on long-term survival in a nationwide cohort of patients operated for nonsmall cell lung cancer (NSCLC). All patients operated for NSCLC in Iceland during 1991-2010 were included. Demographic and clinicopathological features were compared in patients diagnosed incidentally using chest radiography or computed tomography (CT), and in those with symptomatic presentation. Multivariate analysis was used to evaluate prognostic factors. Out of 508 patients, 174 (34%) were diagnosed incidentally; in 26% of cases by chest radiography and in 8% by CT. The CT-detected tumours were significantly smaller than symptomatic tumours, diagnosed at earlier TNM (tumour, node and metastasis) stages and more often of adenocarcinoma histology. 5-year cancer-specific survival for symptomatic versus incidentally diagnosed patients detected by chest radiography and CT was 41%, 57% and 68%, respectively (p=0.003). After adjusting for stage, the hazard ratio (HR) for NSCLC mortality was significantly lower for incidental diagnosis by CT (HR 0.55, 95% CI 0.31‒0.98; p=0.04) compared to incidental diagnosis by chest radiography (HR 0.95, 95% CI 0.70‒1.27; p=0.71) or symptomatic diagnosis (HR 1.0). One-third of surgically treated NSCLCs were detected incidentally, with an increasing rate of incidental CT diagnosis. NSCLC patients diagnosed incidentally by CT appear to have better survival than those diagnosed incidentally by chest radiography, and particularly those who present with symptoms. |
author2 |
1 Dept of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland. 2 Dept of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA. 3 Dept of Pulmonology, Landspitali University Hospital, Reykjavik, Iceland. 4 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Orrason, Andri W Sigurdsson, Martin I Baldvinsson, Kristjan Thorsteinsson, Hunbogi Jonsson, Steinn Gudbjartsson, Tomas |
author_facet |
Orrason, Andri W Sigurdsson, Martin I Baldvinsson, Kristjan Thorsteinsson, Hunbogi Jonsson, Steinn Gudbjartsson, Tomas |
author_sort |
Orrason, Andri W |
title |
Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
title_short |
Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
title_full |
Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
title_fullStr |
Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
title_full_unstemmed |
Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
title_sort |
incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. |
publisher |
European Respiratory Society |
publishDate |
2017 |
url |
http://hdl.handle.net/2336/620176 https://doi.org/10.1183/23120541.00106-2016 |
long_lat |
ENVELOPE(29.443,29.443,69.896,69.896) ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
Smella TNM |
geographic_facet |
Smella TNM |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406653/pdf/00106-2016.pdf Incidental detection by computed tomography is an independent prognostic factor for survival in patients operated for nonsmall cell lung carcinoma. 2017, 3 (2) ERJ Open Res 28462235 doi:10.1183/23120541.00106-2016 http://hdl.handle.net/2336/620176 ERJ open research |
op_rights |
Archived with thanks to ERJ open research Open Access - Opinn aðgangur |
op_doi |
https://doi.org/10.1183/23120541.00106-2016 |
container_title |
ERJ Open Research |
container_volume |
3 |
container_issue |
2 |
container_start_page |
00106-2016 |
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1766041933189218304 |