Primary aldosteronism: from case detection to histopathology with up to 6 years of follow-up.

• Published in: The Journal of Clinical Hypertension
• Main Authors: Jonsdottir, Gudbjörg, Gudmundsson, Jon, Birgisson, Gudjon, Sigurjonsdottir, Helga Agusta
• Other Authors: 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2Division of Interventional Radiology, Department of Radiology, Landspitali University Hospital, Reykjavik, Iceland. 3Department of Surgery, Landspitali University Hospital, Reykjavik, Iceland. 4Division of Endocrinology, Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley Periodicals Inc. 2016
• Subjects: Efnaskipta- og innkirtlalækningar; Innkirtlasjúkdómar; END12; DAI12; SAM12; Hyperaldosteronism; Treatment Outcome; Smella; Iceland
• Online Access: http://hdl.handle.net/2336/620104; https://doi.org/10.1111/jch.12947

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenTo access publisher's full text version of this article click on the hyperlink at the bottom of the page The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long-term outcomes after interventions in patients diagnosed with primary aldosteronism (PA) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA during the years 2007-2011 at Landspitali Hospital in Iceland, a referral center for the whole country. Workup after detection included salt loading test, positional test, computed tomography, and adrenal vein sampling. Patients with unilateral disease were offered treatment with adrenalectomy. A total of 33 patients were diagnosed with PA during the study period: 17 patients with bilateral disease and 16 with unilateral disease. Results from salt loading test were positive in 90% of patients. In patients with adenoma, 36% were responsive on their positional test and computed tomography scan showed a nodule in 73%. All patients with unilateral disease had a lateralization index ≥3. After surgery, patients had lower systolic blood pressure (P<.001) and number of hypertensive medications (P<.01). Landspitali University Hospital Research Fund