Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page A chemical investigation of the sponge (Porifera) Myxilla incrustans collected from the unique submarine hydrothermal vent site Strytan, North of Iceland, revealed a novel family of closely...
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Georg Thime Verlag KG
2016
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Online Access: | http://hdl.handle.net/2336/618435 https://doi.org/10.1055/s-0042-105877 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/618435 2023-05-15T16:51:49+02:00 Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. Einarsdottir, Eydis Liu, Hong-Bing Freysdottir, Jona Gotfredsen, Charlotte Held Omarsdottir, Sesselja 1 Univ Iceland, Fac Pharmaceut Sci, Sch Hlth Sci, Hofsvallagata 53, IS-107 Reykjavik, Iceland 2 Landspitali, Ctr Rheumatol Res, Reykjavik, Iceland 3 Landspitali, Dept Immunol, Reykjavik, Iceland 4 Univ Iceland, Fac Med, Biomed Ctr, Reykjavik, Iceland 5 Tech Univ Denmark, Dept Chem, Lyngby, Denmark 2016 http://hdl.handle.net/2336/618435 https://doi.org/10.1055/s-0042-105877 en eng Georg Thime Verlag KG http://dx.doi.org/ 10.1055/s-0042-105877 Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. 2016, 82 (9-10):903-9 Planta Med. 1439-0221 27135626 doi:10.1055/s-0042-105877 http://hdl.handle.net/2336/618435 Planta medica Archived with thanks to Planta medica Closed - Lokað NAF12 Porifera Immunomodulation Dendritic Cells Article 2016 ftlandspitaliuni https://doi.org/10.1055/s-0042-105877 2022-05-29T08:22:10Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page A chemical investigation of the sponge (Porifera) Myxilla incrustans collected from the unique submarine hydrothermal vent site Strytan, North of Iceland, revealed a novel family of closely related N-acyl dopamine glycosides. Three new compounds, myxillin A (1), B (2) and C (3), were isolated and structurally elucidated using several analytical techniques, such as HR-MS, 1D and 2D NMR spectroscopy. Myxillin A (1) and B (2)were shown to be structurally similar, composed of a dopamine moiety, but differ in the acyl chain length and saturation. The myxillin C (3) has a dehydrotyrosine moiety composing the same acyl chain and glycosylation as myxillin B (2). Myxillins A (1) and C (3) were tested for immunomodulating activity in an in vitro dendritic cell model. Dendritic cells matured and stimulated in the presence of myxillin A (1) secreted lower levels of IL-12p40, whilst dendritic cells matured and stimulated in the presence of myxillin C (3) secreted lower levels of IL-10 compared with dendritic cells matured and stimulated in the presence of the solvent alone. These opposing results indicate that the structural differences in the aromatic ring part of the molecules could have an impact on the immunological effects of dendritic cells. These molecules could, therefore, prove to be important in preventing inflammatory diseases on the one hand, and inducing a response to fight tumors and/or pathogens on the other hand. Further studies will be needed to confirm these potential uses. Eimskip University Fund Icelandic Research Fund (The Icelandic Centre for Research) Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Planta Medica 82 09/10 903 909 |
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Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
NAF12 Porifera Immunomodulation Dendritic Cells |
spellingShingle |
NAF12 Porifera Immunomodulation Dendritic Cells Einarsdottir, Eydis Liu, Hong-Bing Freysdottir, Jona Gotfredsen, Charlotte Held Omarsdottir, Sesselja Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
topic_facet |
NAF12 Porifera Immunomodulation Dendritic Cells |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page A chemical investigation of the sponge (Porifera) Myxilla incrustans collected from the unique submarine hydrothermal vent site Strytan, North of Iceland, revealed a novel family of closely related N-acyl dopamine glycosides. Three new compounds, myxillin A (1), B (2) and C (3), were isolated and structurally elucidated using several analytical techniques, such as HR-MS, 1D and 2D NMR spectroscopy. Myxillin A (1) and B (2)were shown to be structurally similar, composed of a dopamine moiety, but differ in the acyl chain length and saturation. The myxillin C (3) has a dehydrotyrosine moiety composing the same acyl chain and glycosylation as myxillin B (2). Myxillins A (1) and C (3) were tested for immunomodulating activity in an in vitro dendritic cell model. Dendritic cells matured and stimulated in the presence of myxillin A (1) secreted lower levels of IL-12p40, whilst dendritic cells matured and stimulated in the presence of myxillin C (3) secreted lower levels of IL-10 compared with dendritic cells matured and stimulated in the presence of the solvent alone. These opposing results indicate that the structural differences in the aromatic ring part of the molecules could have an impact on the immunological effects of dendritic cells. These molecules could, therefore, prove to be important in preventing inflammatory diseases on the one hand, and inducing a response to fight tumors and/or pathogens on the other hand. Further studies will be needed to confirm these potential uses. Eimskip University Fund Icelandic Research Fund (The Icelandic Centre for Research) |
author2 |
1 Univ Iceland, Fac Pharmaceut Sci, Sch Hlth Sci, Hofsvallagata 53, IS-107 Reykjavik, Iceland 2 Landspitali, Ctr Rheumatol Res, Reykjavik, Iceland 3 Landspitali, Dept Immunol, Reykjavik, Iceland 4 Univ Iceland, Fac Med, Biomed Ctr, Reykjavik, Iceland 5 Tech Univ Denmark, Dept Chem, Lyngby, Denmark |
format |
Article in Journal/Newspaper |
author |
Einarsdottir, Eydis Liu, Hong-Bing Freysdottir, Jona Gotfredsen, Charlotte Held Omarsdottir, Sesselja |
author_facet |
Einarsdottir, Eydis Liu, Hong-Bing Freysdottir, Jona Gotfredsen, Charlotte Held Omarsdottir, Sesselja |
author_sort |
Einarsdottir, Eydis |
title |
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
title_short |
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
title_full |
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
title_fullStr |
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
title_full_unstemmed |
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. |
title_sort |
immunomodulatory n-acyl dopamine glycosides from the icelandic marine sponge myxilla incrustans collected at a hydrothermal vent site. |
publisher |
Georg Thime Verlag KG |
publishDate |
2016 |
url |
http://hdl.handle.net/2336/618435 https://doi.org/10.1055/s-0042-105877 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/ 10.1055/s-0042-105877 Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site. 2016, 82 (9-10):903-9 Planta Med. 1439-0221 27135626 doi:10.1055/s-0042-105877 http://hdl.handle.net/2336/618435 Planta medica |
op_rights |
Archived with thanks to Planta medica Closed - Lokað |
op_doi |
https://doi.org/10.1055/s-0042-105877 |
container_title |
Planta Medica |
container_volume |
82 |
container_issue |
09/10 |
container_start_page |
903 |
op_container_end_page |
909 |
_version_ |
1766041932368183296 |