Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Toxoplasmosis is a disease caused by the intracellular protozoan parasite, Toxoplasma gondii which infects up to one-third of the world human population. Toxoplasmosis in neonates and immun...
Published in: | Scandinavian Journal of Infectious Diseases |
---|---|
Main Authors: | , , , , , , , , |
Format: | Manuscript |
Language: | English |
Published: |
2006
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/6161 https://doi.org/10.1080/00365540600606556 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/6161 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/6161 2023-05-15T16:47:12+02:00 Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland Birgisdottir, Alda Asbjornsdottir, Hulda Cook, Elisabet Gislason, David Jansson, Christer Olafsson, Isleifur Gislason, Thorarinn Jogi, Rain Thjodleifsson, Bjarni 2006-11-20 YES http://hdl.handle.net/2336/6161 https://doi.org/10.1080/00365540600606556 en eng http://dx.doi.org/10.1080/00365540600606556 Scand J Infect Dis. 2006, 38(8):625-31 0036-5548 16857606 doi:10.1080/00365540600606556 GAS12 http://hdl.handle.net/2336/6161 Adult Animals Asthma C-Reactive Protein Cats Estonia/epidemiology Female Humans Hypersensitivity Iceland/epidemiology Immunoglobulin E Male Middle Aged Research Support Non-U.S. Gov't Risk Factors Seroepidemiologic Studies Sweden/epidemiology Toxoplasma Toxoplasmosis Manuscript 2006 ftlandspitaliuni https://doi.org/10.1080/00365540600606556 2022-05-29T08:20:55Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Toxoplasmosis is a disease caused by the intracellular protozoan parasite, Toxoplasma gondii which infects up to one-third of the world human population. Toxoplasmosis in neonates and immunocompromised patients can lead to severe disease and death. We investigated the prevalence and risk factors for T. gondii infection in Iceland, Sweden and Estonia, and tested the hypothesis that T. gondii infection causes systemic inflammation and protects against atopy. Blood samples were collected from 1277 randomly selected subjects. The presence of T. gondii IgG antibodies was determined by an ELISA method and levels of Hs-CRP by immunoturbidimetric assay. The prevalence of T. gondii antibodies was 54.9% in Tartu, 23% in Uppsala and 9.8% in Reykjavik (p<0.0001). The risk of positive T. gondii antibodies increased with the number of siblings and with age in Sweden. T. gondii infection was associated with asthma related symptoms and increased Hs-CRP (p = 0.02). No association was found with IgE-sensitization and lung function. We concluded that risk factors for T. gondii infection suggested that soil exposure was 1 of the mechanisms in all 3 countries and a meat-associated infection route is a risk in Sweden. Manuscript Iceland Hirsla - Landspítali University Hospital research archive Scandinavian Journal of Infectious Diseases 38 8 625 631 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adult Animals Asthma C-Reactive Protein Cats Estonia/epidemiology Female Humans Hypersensitivity Iceland/epidemiology Immunoglobulin E Male Middle Aged Research Support Non-U.S. Gov't Risk Factors Seroepidemiologic Studies Sweden/epidemiology Toxoplasma Toxoplasmosis |
spellingShingle |
Adult Animals Asthma C-Reactive Protein Cats Estonia/epidemiology Female Humans Hypersensitivity Iceland/epidemiology Immunoglobulin E Male Middle Aged Research Support Non-U.S. Gov't Risk Factors Seroepidemiologic Studies Sweden/epidemiology Toxoplasma Toxoplasmosis Birgisdottir, Alda Asbjornsdottir, Hulda Cook, Elisabet Gislason, David Jansson, Christer Olafsson, Isleifur Gislason, Thorarinn Jogi, Rain Thjodleifsson, Bjarni Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
topic_facet |
Adult Animals Asthma C-Reactive Protein Cats Estonia/epidemiology Female Humans Hypersensitivity Iceland/epidemiology Immunoglobulin E Male Middle Aged Research Support Non-U.S. Gov't Risk Factors Seroepidemiologic Studies Sweden/epidemiology Toxoplasma Toxoplasmosis |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Toxoplasmosis is a disease caused by the intracellular protozoan parasite, Toxoplasma gondii which infects up to one-third of the world human population. Toxoplasmosis in neonates and immunocompromised patients can lead to severe disease and death. We investigated the prevalence and risk factors for T. gondii infection in Iceland, Sweden and Estonia, and tested the hypothesis that T. gondii infection causes systemic inflammation and protects against atopy. Blood samples were collected from 1277 randomly selected subjects. The presence of T. gondii IgG antibodies was determined by an ELISA method and levels of Hs-CRP by immunoturbidimetric assay. The prevalence of T. gondii antibodies was 54.9% in Tartu, 23% in Uppsala and 9.8% in Reykjavik (p<0.0001). The risk of positive T. gondii antibodies increased with the number of siblings and with age in Sweden. T. gondii infection was associated with asthma related symptoms and increased Hs-CRP (p = 0.02). No association was found with IgE-sensitization and lung function. We concluded that risk factors for T. gondii infection suggested that soil exposure was 1 of the mechanisms in all 3 countries and a meat-associated infection route is a risk in Sweden. |
format |
Manuscript |
author |
Birgisdottir, Alda Asbjornsdottir, Hulda Cook, Elisabet Gislason, David Jansson, Christer Olafsson, Isleifur Gislason, Thorarinn Jogi, Rain Thjodleifsson, Bjarni |
author_facet |
Birgisdottir, Alda Asbjornsdottir, Hulda Cook, Elisabet Gislason, David Jansson, Christer Olafsson, Isleifur Gislason, Thorarinn Jogi, Rain Thjodleifsson, Bjarni |
author_sort |
Birgisdottir, Alda |
title |
Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
title_short |
Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
title_full |
Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
title_fullStr |
Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
title_full_unstemmed |
Seroprevalence of Toxoplasma gondii in Sweden, Estonia and Iceland |
title_sort |
seroprevalence of toxoplasma gondii in sweden, estonia and iceland |
publishDate |
2006 |
url |
http://hdl.handle.net/2336/6161 https://doi.org/10.1080/00365540600606556 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1080/00365540600606556 Scand J Infect Dis. 2006, 38(8):625-31 0036-5548 16857606 doi:10.1080/00365540600606556 GAS12 http://hdl.handle.net/2336/6161 |
op_doi |
https://doi.org/10.1080/00365540600606556 |
container_title |
Scandinavian Journal of Infectious Diseases |
container_volume |
38 |
container_issue |
8 |
container_start_page |
625 |
op_container_end_page |
631 |
_version_ |
1766037278908481536 |